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Publikováno v:
Neuroscience. 440:196-209
Patients suffering with functional somatic pain syndromes such as temporomandibular disorders (TMD) and fibromyalgia syndrome (FMS) have some similar symptoms, but the underlying cause is still unclear. The purpose of this study was to investigate wh
Autor:
Ali Akbar Owji, Mohammad Ali Takhshid, Farideh Jalali Mashayekhi, Zahra Khoshdel, Somayeh Ahmadpour Jirandeh, Shahla Shojaei
Publikováno v:
Neuroscience. 422:54-64
The pancreatic peptide, Amylin (AMY), reportedly affects nociception in rodents. Here, we investigated the potential effect of AMY on the tolerance to morphine and on the expression of BDNF at both levels of protein and RNA in the lumbar spinal cord
Autor:
Keiichiro Tsunoda, Xiaowen Shi, Jingwei Shang, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Abe, Yasuyuki Ohta, Namiko Matsumoto, Tian Feng, Nozomi Hishikawa, Xia Liu, Takahiro Kuchimaru, Ryo Sasaki, Emi Nomura, Koh Tadokoro, Shinae Kizaka-Kondoh
Publikováno v:
Neuroscience. 415:31-43
Hypoxia inducible factor-1α (HIF-1α) is a key transcription factor that maintains oxygen homeostasis. Hypoxic stress is related to the pathogenesis of amyotrophic lateral sclerosis (ALS), and impaired HIF-1α induces motor neuron degeneration in AL
Publikováno v:
Neuroscience
Repeated stress induces systemic elevations in glucocorticoid levels. Stress is also associated with alterations in central nervous system astrocytes and oligodendrocytes that involve connexins and myelin proteins. Corticosteroid elevation seems a ma
Autor:
Xie Zhang, Qiuju Yuan, Wutian Wu, Pengyun Huang, Rong Liu, Zhi-Xiu Lin, You-Qiang Song, Hongwei Zhang
Publikováno v:
Neuroscience. 409:152-161
Axonopathy manifested by axon swellings might constitute one of the earliest pathological features of Alzheimer's disease. It has been proposed that axonopathy might be associated with the origin of Aβ plaques. However, how axonopathy leads to Aβ p
Autor:
Subrata Kumar Shil, Sho Sato, Kenyu Kamizato, Yui Yamamoto, Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Yuki Yasumoto, Hirofumi Miyazaki, Masaki Ogata, Yuji Owada, Yuko Okuyama, Naoto Ishii
Publikováno v:
Neuroscience. 409:120-129
Fatty acid binding protein 7 (FABP7) is expressed in astrocytes of the developing and mature central nervous system, and modulates astrocyte function by controlling intracellular fatty acid homeostasis. Astrocytes in the spinal cord have an important
Publikováno v:
Neuroscience. 459
Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated mi
Publikováno v:
Neuroscience. 449
This is the first study to examine the influence of activity in one limb on corticospinal excitability to the contralateral limb during a locomotor output. Corticospinal and spinal excitability to the biceps brachii of the ipsilateral arm were assess
Publikováno v:
Neuroscience. 385:102-120
Neonatal injury-induced exaggeration of pain hypersensitivity after adult trauma is a significant clinical challenge. However, the underlying mechanisms remain poorly understood. Growing evidence shows that spinal Src homology-2 domain-containing pro
Autor:
Agustina Lara, Maria Meyer, Hazel Hunt, Alejandro F. De Nicola, E. Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Joseph K. Belanoff
Publikováno v:
Neuroscience. 384:384-396
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and