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Publikováno v:
Neuroscience. 463:238-253
Clinical studies clearly indicate that early-life stress (ELS) may cause physical and mental health problems later in life. Therefore, the identification of universal biomarkers of ELS-related diseases is very important. The 70-kDa heat shock protein
Autor:
Teresa A. Milner, Joshua F. Kogan, Yan Zhou, Jason D. Gray, Mary Jeanne Kreek, Konrad T. Ben, James D. Ryan, Farah K. Bshesh, Natalina H. Contoreggi, Bruce S. McEwen
Publikováno v:
Neuroscience. 393:236-257
Although opioid addiction has risen dramatically, the role of gender in addiction has been difficult to elucidate. We previously found sex-dependent differences in the hippocampal opioid system of Sprague–Dawley rats that may promote associative le
Publikováno v:
Neuroscience. 424
Excessive dietary fat intake is considered a great risk factor for metabolic disorders as well as cognitive dysfunction. However, the potential mechanisms underlying the effects of a high-fat diet (HFD) on the brain remain rather obscure. The purpose
Publikováno v:
Neuroscience. 408
It is commonly recognized that physical exercise positively affects several CNS regions and improves cognitive abilities. For example, exercise is associated with an increase in neurogenesis and facilitation of long-term potentiation in the hippocamp
Publikováno v:
Neuroscience. 324:355-366
Aberrant activation of the developing immune system can have long-term negative consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia, the brain’s resident immune cells, which could contribute to the lifelong defic
Publikováno v:
Neuroscience. 306:1-9
Learning and memory impairment is one of the most challenging complications of cirrhosis and present treatments are unsatisfactory. The exact mechanism of cirrhosis cognitive dysfunction is unknown. Pregnenolone sulfate (PREGS) is an excitatory neuro
Autor:
Qin Wang, X.-H. Kang, Ning Wang, Cheng-Di Liu, Jing Ai, Tong Liu, De-Kang Zong, Ji-Chao Ma, Lihua Sun, Shuang-Chao Pei, Xudong Wang, Xinren Chen, Ming-Jing Duan, Mei-Ling Yan
Publikováno v:
Neuroscience. 299:66-78
Large cohort studies have revealed a close relationship between cognitive impairment and cardiovascular diseases, although the mechanism underlying this relationship remains incompletely understood. In this study, using a transgenic (Tg) mouse model
Autor:
Roxanne M. Kaercher, Sarah E. Royer, Sarah C. Hopp, Gary L. Wenk, Linda Adzovic, Heather M. D’Angelo
Publikováno v:
Neuroscience. 280:10-18
Age-associated memory impairments may result as a consequence of neuroinflammatory induction of intracellular calcium (Ca(+2)) dysregulation. Altered L-type voltage-dependent calcium channel (L-VDCC) and ryanodine receptor (RyR) activity may underlie
Publikováno v:
Neuroscience. 362
Although deep-brain stimulation (DBS) of the lateral habenula (LHb) has been successfully applied to treatment-resistant depression for years, the mechanism is still unclear. Previous researches have demonstrated that LHb-DBS elevates brain monoamine
Publikováno v:
Neuroscience. 358
Recent evidence suggests that ischemia/reperfusion (I/R) in an organ may have distance effect on the brain. In this study, the effects of renal I/R, limb I/R or both together on the structural and function of hippocampus were evaluated and compared.