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Autor:
Anna M. Czarnecka, Jolanta Konieczny, Lucyna Antkiewicz-Michaluk, Tomasz Lenda, Kinga Kamińska
Publikováno v:
Neuroscience. 340:308-318
A growing body of evidence indicates that impairment of the ubiquitin-proteasome (UPS) system in the substantia nigra (SN) plays an important role in the pathogenesis of Parkinson's disease (PD). The aim of our study was to compare two unilateral rat
Autor:
A. Haj-Mirzaian, S. Amiri, N. Kordjazy, M. Momeny, A. Razmi, M. Rahimi-Balaei, H. Amini-Khoei, H. Marzban, S.E. Mehr, S.H. Ghaffari, A.R. Dehpour
Publikováno v:
Neuroscience. 315:271-285
The neuroimmune-endocrine dysfunction has been accepted as one of fundamental mechanisms contributing to the pathophysiology of psychiatric disorders including depression and anxiety. In this study, we aimed to evaluate the involvement of hypothalami
Publikováno v:
Neuroscience. 311:130-137
The present study was to investigate whether baicalin can prevent repeated exogenous corticosterone injection-induced depressive-like behaviors and explore its possible mechanisms. After a 21-day treatment with baicalin (10 and 20 mg/kg), sucrose pre
Autor:
Qiao-Jun Zhang, H.H. Tan, Ling Zhang, X.L. Niu, Cheng-Xue Du, Li Bo Li, Jian-Xin Liu, Jiye Zhang
Publikováno v:
Neuroscience. 311:45-55
The role of serotonin7 (5-HT7) receptors in the regulation of depression is poorly understood, particularly in Parkinson's disease-associated depression. Here we examined whether 5-HT7 receptors in the prelimbic (PrL) sub-region of the ventral medial
Autor:
Kartik T. Nakhate, Dadasaheb M. Kokare, Sagar J. Desai, Chandrashekhar D. Borkar, Nishikant K. Subhedar
Publikováno v:
Neuroscience. 277:818-830
We investigated the involvement of neuropeptide Y (NPY) in the modulation of cholecystokinin-4 (CCK-4)-evoked anxiety and depression. Adult male mice were injected with vehicle, CCK-4, NPY, NPY Y1 receptor agonist [Leu(31), Pro(34)]-NPY or antagonist
Autor:
Ana Paula Ardais, Rodrigo A. Cunha, Cássia Sallaberry, Lisiane O. Porciúncula, Andreia Silva da Rocha, Maurício Felisberto Borges
Publikováno v:
Neuroscience. 270:27-39
Caffeine is the psychostimulant most consumed worldwide but concerns arise about the growing intake of caffeine-containing drinks by adolescents since the effects of caffeine on cognitive functions and neurochemical aspects of late brain maturation d
Publikováno v:
Neuroscience. 231:125-135
Adderall is widely prescribed for attention deficit hyperactivity disorder (ADHD) though long term neurologi- cal effects of the main ingredient d-amphetamine are not well understood. The purpose of this study was to examine effects of clinically pre
Autor:
Ting Ting Zhao, Kwang-Hyun Shin, Moon-Soon Lee, Hansol Park, Kyeong-Ah Lee, Hong-Sig Kim, Kyoung-Won Kim
Publikováno v:
Neuroscience. 339
The present study investigated the effects of (-)-sesamin on motor and memory deficits in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) with l-3,4-dihydroxyphenylalanine (l-DOPA). MPTP-lesioned
Autor:
Ren-Shan Ge, Sicong Wang, Benfu Wang, Gaolong Zhang, Binbin Wu, Yuyuan Liang, Qingquan Lian, Wenxuan Lin, Zhichuan Chen, Zhanglei Dong
Publikováno v:
Neuroscience. 328
Propofol, a widely used anesthetic, can cause addictive behaviors in both human and experimental animals. In the present study, we examined the involvement of glucocorticoid receptor (GR) signaling in the molecular process by which propofol may cause
Publikováno v:
Neuroscience. 171:284-299
The present study has been designed to explore the protective effect of montelukast (leukotriene receptor antagonist) against intrastriatal quinolinic acid (QA; 300 nmol) and malonic acid (MA; 6 μmol) induced Huntington's like symptoms in rats. Quin