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Autor:
Hasan Alhaddad, Terry D. Hinds, Richard L. Bell, Darren M. Gordon, Youssef Sari, Erin Jarvis, Zachary A. Kipp
Publikováno v:
Neuroscience
Evidence suggests the hypothalamic–pituitary–adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to ca
Autor:
Yan Fan, Meng-Yang Zhu, Katalin Szebeni, Craig A. Stockmeier, Attila Szebeni, Muhammad U. Raza, Ping Chen, Gregory A. Ordway
Publikováno v:
Neuroscience. 393:123-137
Phox2a and Phox2b are two homeodomain transcription factors playing a pivotal role in the development of noradrenergic neurons during the embryonic period. However, their expression and function in adulthood remain to be elucidated. Using human postm
Autor:
Edina Szucs, Ewelina Rojewska, Barbara Przewlocka, Joanna Mika, Agnieszka Wawrzczak-Bargiela, Sándor Benyhe, Joanna Starnowska, Ryszard Przewlocki
Publikováno v:
Neuroscience. 390:293-302
Clinical studies have reported lower effectivity of opioid drugs in therapy of neuropathic pain. Therefore, to determine the changes in endogenous opioid systems in this pain more precisely, we have studied the changes in the pain-related behavior on
Publikováno v:
Neuroscience. 388:448-459
Anxiety disorder is a major psychiatric disorder characterized by fear, worry, and excessive rumination. However, the molecular mechanisms underlying neural plasticity and anxiety remain unclear. Here, we utilized a mouse model of anxiety-like behavi
Autor:
Yu Wan, Zheqiong Yang, Xianfei Xie, Jiang Yue, Furong Zhang, Jie Li, Shufang Na, Juan Wu, Ke Li
Publikováno v:
Neuroscience. 379:115-125
Brain CYP2D is responsible for the synthesis of endogenous neurotransmitters such as dopamine and serotonin. This study is to investigate the effects of cerebral CYP2D on mouse behavior and the mechanism whereby growth hormone regulates brain CYP2D.
Publikováno v:
Neuroscience. 357:295-302
The molecular mechanism of individual response of susceptibility and resilience under psychological stress remains controversial and unclear. The present study aimed to explore the relationship of metabotropic glutamate receptor 5 (mGluR5) with gluco
Autor:
Dianne P. Figlewicz, Elaine R. Peskind, Kim M. Hansen, William A. Banks, Patricia Szot, Allyn Franklin, Kristin M. Bullock, Timothy Petru Beuca, Murray A. Raskind
Publikováno v:
Neuroscience. 355:9-21
Neuroinflammation is proposed to be an important component in the development of several central nervous system (CNS) disorders including depression, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. However, exactly how neuroinfl
Autor:
Thomas van Groen, Mark Bolding, Christianne E. Strang, Fred G. Oliveira-Souza, Alexis E. Lambert, Marci L DeRamus
Publikováno v:
Neuroscience. 354:43-53
Alzheimer's disease (AD), a debilitating neurodegenerative illness, is characterized by neuronal cell loss, mental deficits, and abnormalities in several neurotransmitter and protein systems. AD is also associated with visual disturbances, but their
Publikováno v:
Neuroscience. 344:178-186
Patients with multiple sclerosis (MS) often complain of neuropathic pain. According to the Gate Control Theory of Pain, spinal networks of GABAergic inhibitory interneurons are important in modulating nociceptive inputs from the periphery. Na+-K+-2Cl
Autor:
Haichao Wang, Yonghui Wang, Renjia Li, Weiqiang Chen, Xiaoling Zhao, Wanqi Zhang, Fengqin Liu, Haimin Jin
Publikováno v:
Neuroscience. 346:226-237
Stress-induced neural injuries are closely linked to the pathogenesis of various neuropsychiatric disorders and psychosomatic diseases. We and others have previously demonstrated certain protective effects of epigallocatechin-3-gallate (EGCG) in stre