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Autor:
Kristoffer L. Egerod, Stefan Offermanns, Thue W. Schwartz, Mark K. Nøhr, Morten Møller, Andreas Gille, Søren H. Christiansen
Publikováno v:
Neuroscience. 290:126-137
G-protein-coupled receptor 41 (GPR41) also called free fatty acid receptor 3 (FFAR3) is a Gαi-coupled receptor activated by short-chain fatty acids (SCFAs) mainly produced from dietary complex carbohydrate fibers in the large intestine as products o
Autor:
Erica Sarchielli, Gabriella B. Vannelli, Pasquale Gallina, Stefano Ambrosini, Annamaria Morelli, Berardino Porfirio, Paolo Comeglio
Publikováno v:
Neuroscience. 289:123-133
Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the dis
Publikováno v:
Neuroscience. 286:1-12
Polycytosine-binding proteins (PCBPs) are RNA-binding proteins that participate in post-transcriptional control pathways. Among the diverse functions of these proteins is the interaction with a 27 nucleotide pyrimidine-rich domain within the 3′UTR
Publikováno v:
Neuroscience. 358
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in dopaminergic neurons. α-Synuclein (α-syn), a major protein component of LBs, is known to regulate synaptic plasticity, with a crucial role in memory and motor functi
Publikováno v:
Neuroscience. 269:43-58
In rodents, many social behaviors are driven by the sense of smell. The vomeronasal organ (VNO), part of the accessory olfactory system mediates many of these chemically driven behaviors. The VNO is heavily vascularized, and is readily accessible to
Autor:
Norimitsu Morioka, Yoshihiro Nakata, Masato Tokuhara, Sakura Harano, Yoki Nakamura, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Y. Idenoshita
Publikováno v:
Neuroscience. 258:374-384
Although the clearance of glutamate from the synapse under physiological conditions is performed by astrocytic glutamate transporters, their expression might be diminished under pathological conditions. Microglia glutamate transporters, however, migh
Publikováno v:
Neuroscience. 225:9-21
The bed nucleus of the stria terminalis (BNST) plays a critical role in regulating the behavioral response to stress. Stressors that activate the BNST also activate serotonergic (5-HT) systems. Hence, maladaptive changes of 5-HT receptor expression m
Publikováno v:
Neuroscience. 165:386-394
Activation of microglial cells, the resident immune cells of the CNS causes neurotoxicity through the release of a wide array of inflammatory mediators including proinflammatory cytokines, chemokines and reactive oxygen species. In this study, we hav
Publikováno v:
Neuroscience. 164:948-962
This study aimed to investigate the effect of hypoxia on the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), microsomal prostaglandin-E synthase (mPGES-1), E-prostanoid receptor 2 (EP2) in microglia; and the roles of EP2-cyclic aden
Autor:
Margaret M. Koletar, P.K.P. Lee, Jennifer A. Chalmers, Sarah Gingerich, Denise D. Belsham, X. Wang, Sandeep S. Dhillon
Publikováno v:
Neuroscience. 162:1134-1140
Significant information on reproductive function has been generated based on the rat model, including many seminal discoveries. Yet little is known about the molecular and cellular events involved in control of reproductive function, mainly due to th