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Autor:
Koichi Iwata, Ikuko Shibuta, Naoto Taguchi, Hitoshi Sato, Akihiko Furukawa, Masatoshi Ando, Takanobu Inada, Eri Oshima, Hiromasa Tsuda, Tatsuo Shirota, Jo Otsuji, Suzuro Hitomi, Masamichi Shinoda, Yoshinori Hayashi
Publikováno v:
Neuroscience. 468:43-52
Sensory disturbance in the orofacial region owing to trigeminal nerve injury is caused by dental treatment or accident. Commercially available therapeutics are ineffective for the treatment of sensory disturbance. Additionally, the therapeutic effect
Publikováno v:
Neuroscience. 468:199-210
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a crucial regulator of neuronal development, neuronal survival, axonal regeneration, and synaptic plasticity. In this study we examined the potential role of PTEN in cognitive functio
Publikováno v:
Neuroscience. 466:148-161
Anesthesia and surgery are associated with perioperative neurocognitive disorders (PND). Dexmedetomidine is known to improve PND in rats; however, little is known about the mechanisms. Male Sprague-Dawley rats were subjected to resection of the hepat
Autor:
Claire E. Manning, Vedrana Bali, Shantée N. Ayala Rosario, Minerva Rodriguez, Michelle S. Mazei-Robison, Sarah C. Simmons, Marie A. Doyle, Ali R. Stark, Alfred J. Robison
Publikováno v:
Neuroscience
Despite the high prevalence of major depressive disorder (MDD), understanding of the biological underpinnings remains limited. Rodent models suggest that changes in activity and output of dopamine (DA) neurons in the ventral tegmental area (VTA) are
Publikováno v:
Neuroscience. 463:216-226
Objective: Cognitive dysfunction often accompanies diabetes. Both hypoglycemia and hyperglycemia cause cognitive dysfunctions. However, the underlying pathophysiology remains unclear. Recent evidence show that ferroptosis primarily triggers nerve cel
Publikováno v:
Neuroscience
Activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling in cardiovascular regulatory regions of the brain contributes to sympathetic excitation in myocardial infarction (MI)-induced heart failure (HF) by increasing brain renin-
Autor:
Nima Bakhtiari, Alireza Farnam, Alireza Sarkaki, Seyed Ali Mard, Javad Mahmoudi, Neda Yazdanfar
Publikováno v:
Neuroscience. 461:80-90
Maternal opioids abuse has some deleterious consequences on next generations. Besides, children's rearing conditions can affect the behavioral states and brain plasticity in their later life. In the present study, we investigated the effects of mater
Autor:
Amir Ghanbari, Seyyed Behnamodin Jame'ei, Parichehr Pasbakhsh, Zeinab Namjoo, Kazem Zibara, Showan Amani, Roya Aryanpour, Iraj Ragerdi Kashani, Reza Mahmoudi
Publikováno v:
Neuroscience. 463:116-127
Estrogen produces a beneficial role in animal models of multiple sclerosis (MS). The effect of 17β-estradiol therapy on microglia polarization and neuroinflammation in the corpus callosum of the cuprizone-induced demyelination model has not been elu
Autor:
Tong Li, Shuwei Jia, Dongyang Li, Haitao Liu, Xiaoyu Liu, Xiaoran Wang, Danian Qin, Yu-Feng Wang, Ping Wang
Publikováno v:
Neuroscience. 452:13-25
Suckling-evoked pulsatile release of oxytocin (OT) from the posterior pituitary plays a key role in breastfeeding, which relies on burst-like discharges of OT neurons. To explore cellular mechanisms regulating OT neuronal activity, using lactating ra
Publikováno v:
Neuroscience
Highlights • Human hippocampal progenitor cells (HPCs) and tissue express classical sex hormone receptors. • Prolactin does not impact human HPCs maintained in a proliferative state. • Prolactin increases neuronal differentiation of human HPCs