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Autor:
Melissa A. Tapia, Emily L. Bathe, Frank W. Booth, Valerie N. Weise, Matthew J. Will, Jenna R. Lee, Victoria J. Vieira-Potter
Publikováno v:
Neuropharmacology. 155:22-30
Palatability driven feeding and voluntary physical activity are mediated by and influence similar neural mechanisms, notably through the actions of opioids within the nucleus accumbens. Recent studies suggest that access to a voluntary running wheel
Publikováno v:
Neuropharmacology. 151:159-170
Niemann Pick C (NPC) is a fatal hereditary neurovisceral disorder associated with a progressive loss of neurons of unknown mechanism. The disease is caused by mutation in either of two genes, termed npc1 and npc2, accounting for ∼95% and ∼5% of p
Autor:
Koichi Tan-No, Wakana Sakuma, Osamu Nakagawasai, Takayo Odaira, Kohei Takahashi, Jia-Rong Lin, Hiroshi Onogi, Lalit K. Srivastava, Wataru Nemoto
Publikováno v:
Neuropharmacology. 150:1-14
Methylazoxymethanol (MAM)-treated pregnant rat at gestation day (GD) 17 has been shown to be a valuable developmental animal model for schizophrenia. Yet, this model remains to be established in mice. In the present study, we examined behavioral, cyt
Autor:
Tsuyoshi Saitoh, Mustafa Korkutata, Shuji Ioka, Fumihiro Sugiyama, Jiang-Fan Chen, Yoan Cherasse, Nobuyuki Murakoshi, Shinya Fujii, Hidetoshi Kumagai, Xuzhao Zhou, Feng Duo, Rujie Qin, Hiroshi Nagase, Michael Lazarus
Publikováno v:
Neuropharmacology. 144:122-132
Insomnia is one of the most common sleep problems with an estimated prevalence of 10%-15% in the general population. Although adenosine A2A receptor (A2AR) agonists strongly induce sleep, their cardiovascular effects preclude their use in treating sl
Autor:
Sara R. Jones, Patrick J. Mulholland, Diana Fulmer, Jennifer A. Rinker, Reginald Cannady, Michaela Hoffman, Natalie S. McGuier
Publikováno v:
Neuropharmacology. 138:10-19
Currently available pharmacotherapies for treating alcohol use disorder (AUD) suffer from deleterious side effects and are not efficacious in diverse populations. Clinical and preclinical studies provide evidence that the Kcnq family of genes that en
Publikováno v:
Neuropharmacology. 187
Beyond abnormalities in the neurotransmitter hypothesis, recent evidence suggests that mitochondrial dysfunction and immune-inflammatory responses contribute to the pathophysiology of schizophrenia. The prefrontal cortex (PFC) undergoes maturation an
Autor:
Denis Soulet, Mélanie Bourque, Amandine Isenbrandt, Thérèse Di Paolo, Katherine Coulombe, Marc Morissette, Jérôme Lamontagne-Proulx
Publikováno v:
Neuropharmacology. 201:108784
The main neuropathological feature of Parkinson's disease (PD) is degeneration of dopamine (DA) neurons in the substantia nigra (SN); PD prevalence is higher in men, suggesting a role of sex hormones in neuroprotection. This study sought the effects
Autor:
Liisa A.M. Galea, Paula Duarte-Guterman, Wansu Qiu, Kimberly A. Go, Yvonne Lamers, Rand S. Eid
Publikováno v:
Neuropharmacology. 175
Perinatal depression (PND) affects approximately 15% of women, and de novo postpartum depression affects approximately 40% of PND cases. Selective serotonin reuptake inhibitors (SSRIs) are a common class of antidepressants prescribed to treat PND. Ho
Autor:
Yuan Guo, Yaxin Yang, Guanyun Bian, Qiao Jun Zhang, Wenjuan Li, Tian Xu, Li-Bo Li, Hongfei Qiao, Jian Liu
Publikováno v:
Neuropharmacology. 168
Although the lateral habenula (LHb) is involved in the regulation of multiple brain functions and this region expresses abundant M-type potassium channel (M-channel) subunits Kv7.2 and Kv7.3, the role of M-channels in regulating working memory is unc
Publikováno v:
Neuropharmacology. 137:1-12
Changes in brain reward and control systems of frontal cortical areas including the orbitofrontal cortex (OFC) are associated with alcohol use disorders (AUD). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors