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Autor:
Pi-Chuan Fan, Pokai Huang, Lih-Chu Chiou, Chia Chun Hor, Daniel E. Knutson, Werner Sieghart, Tzu-Hsuan Lai, James M. Cook, Ming Tatt Lee, Margot Ernst
Publikováno v:
Neuropharmacology. 140:1-13
Novel treatments against migraine are an urgent medical requirement. α6 subunit-containing GABA(A) receptors (α6GABA(A)Rs) are expressed in trigeminal ganglia (TG), the hub of the trigeminal vascular system (TGVS) that is involved in the pathogenes
Publikováno v:
Neuropharmacology. 203:108881
Although serotonin 1A (5-HT1A) receptor agonists are widely used as the additive compound to reduce l -dopa-induced dyskinesia in Parkinson's disease (PD), few studies focused on the effect and mechanism of 5-HT1A receptor agonist on the motor sympto
Publikováno v:
Neuropharmacology. 105:258-269
The high-voltage spindles (HVSs), one of the characteristic oscillations that include theta frequencies in the basal ganglia (BG)-cortical system, are involved in immobile behavior and show increasing power in Parkinson's disease (PD). Our previous r
Autor:
Justin J. McGraw, Benjamin F. Cravatt, Martin P.K. Leigh, Ajay N. Baindur, Ken T. Wakabayashi, Malte Feja, Caroline E. Bass
Publikováno v:
Neuropharmacology
CB1 receptor antagonists disrupt operant responding for food and drug reinforcers, and cue-induced reinstatement of cocaine and heroin seeking. Conversely, enhancing endocannabinoid signaling, particularly 2-arachidonyl glycerol (2-AG), by inhibition
Autor:
Samira Schultz Mansur, Eduardo Simão da Silva, Moacir Serralvo Faria, Mariana Graciela Terenzi, Brunno Rocha Levone, Elisa Caroline Cella, Marta Aparecida Paschoalini, Ana Paula Dambros Taschetto, Larissa Kochenborger
Publikováno v:
Neuropharmacology. 89:136-145
The present study evaluated the involvement of α-adrenoceptors of the median raphe nucleus (MRN) in satiated rats, in food and water intake and motor behaviour. Control groups were treated with saline (SAL) or adrenaline (ADR), injected into the MRN
Autor:
Virginia Wilson, Paul J. Fletcher, J.D.C. Browne, Patrick McCormick, José N. Nobrega, Gary Remington
Publikováno v:
Neuropharmacology. 89:225-231
Pramipexole is a clinically important dopamine receptor agonist with reported selectivity for dopamine D3 receptors over other dopaminergic and non-dopaminergic sites. Many of its behavioural effects are therefore attributed to D3 receptor activity.
Publikováno v:
Neuropharmacology. 84:31-45
We recently discovered that the activation of the spinal glucagon-like peptide-1 receptors (GLP-1Rs) by the peptidic agonist exenatide produced antinociception in chronic pain. We suggested that the spinal GLP-1Rs are a potential target molecule for
Autor:
José L. Góngora-Alfaro, José L. Bata-García, Fernando J. Álvarez-Cervera, Helena B. Erosa-Rivero, Francisco J. Heredia-López
Publikováno v:
Neuropharmacology. 81:176-187
Extrapyramidal syndromes (EPS) caused by antipsychotic therapy are currently treated with anticholinergics that lack selectivity for the five muscarinic receptor subtypes. Since these receptors are heterogeneously expressed among the different classe
Autor:
Dionéia Araldi, Filipe César do Prado, Cláudia Herrera Tambeli, André Schwambach Vieira, Carlos Amílcar Parada, Maria Cláudia G. Oliveira-Fusaro
Publikováno v:
Neuropharmacology. 67:252-258
We have demonstrated that the activation of P2X3 receptor on peripheral afferent neurons is critical to development of inflammatory hyperalgesia in peripheral tissue, although pharmacological administration of prostaglandin E(2) or sympathomimetic am
Autor:
Tomonori Naka, Hiroshi Takeda, Soichiro Ide, Masabumi Minami, Satoshi Deyama, Tomokazu Nakako, Mitsuhiro Yoshioka, Yuki Majima, Mikie Hirata
Publikováno v:
Neuropharmacology. 67:326-330
We previously demonstrated the critical role of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis (vBNST) in pain-induced aversion. We showed that activation of β-adrenoceptors in this brain region by intr