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of 29
pro vyhledávání: ''
Autor:
Jiadi Xu, Peter C.M. van Zijl, Hanzhang Lu, Wanli W. Smith, Lin Chen, Gongbo Guo, Chunming Gu, Christopher A. Ross, Hongshuai Liu, Jun Hua, Xiaofei He, Peiying Liu, Bo Ning, Wenzhen Duan, Zhiliang Wei, Adnan Bibic
Publikováno v:
Neurodegener Dis
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease and the most common movement disorder characterized by motor impairments resulting from midbrain dopamine neuron loss. Abnormalities in small pial arteries and
Publikováno v:
Neurodegenerative Diseases. 17:181-198
Background/Aims: A novel ataxic mouse line was established from the offspring of a male mouse administered cyclophosphamide in a juvenile period. Methods: We have attempted to examine the phenotype and histopathological changes of affected mice. Furt
Autor:
Ingrid S. Tarr, Roger Pamphlett, Shu Yang, Emily P. McCann, Garth A. Nicholson, Jennifer A. Fifita, Dominic B. Rowe, Ian P. Blair, Alison L. Hogan, Denis C. Bauer, Neil F. W. Saunders, Katharine Y. Zhang, Jasmin Galper, Kelly L. Williams
Publikováno v:
Neurodegenerative Diseases. 17:304-312
Background: Mutations in the genes encoding the heterogeneous nuclear ribonucleoproteins hnRNPA1 and hnRNPA2/B1 have been reported in a multisystem proteinopathy that includes amyotrophic lateral sclerosis (ALS) and inclusion body myopathy associated
Publikováno v:
Neurodegenerative Diseases. 17:63-72
Background and Objectives: The incidence of visual hallucination (VH) increases with Parkinson's disease (PD) progression, and its development is thought to be related to a specific neurodegenerative process in PD. This study aimed to reveal brain de
Autor:
Ezio Giacobini, Armand Savioz, Eniko Veronika Kovari, Panteleimon Giannakopoulos, Constantin Bouras, François Herrmann, William L. Klein
Publikováno v:
Neurodegenerative Diseases, Vol. 16, No 5-6 (2016) pp. 398-406
Background/Aims: Investigations of Aβ oligomers in neuropathologically confirmed Alzheimer's disease (AD) are still scarce. We report neurohistopathological and biochemical analyses using antibodies against tau and amyloid β (Aβ) pathology. Method
Autor:
Sandra A. Billinger, Abdulfattah S. Alqahtani, Jill K. Morris, Eric D. Vidoni, Nicole C. Burns, Jeffrey M. Burns, Hung-Wen Yeh, Kathy L. Newell
Publikováno v:
Neurodegenerative Diseases. 16:218-224
Background: Cerebral β-amyloid angiopathy (CAA) occurs when β-amyloid (Aβ) is deposited in the vascular media and adventitia. It is a common pathology in the brains of older individuals and has been linked to cognitive decline, but relatively litt
Autor:
Isabella Zanella, M Serpente, Daniela Galimberti, Alessandro Padovani, Stefano Gazzina, Barbara Borroni, Enrico Premi, Roberto Gasparotti, Giorgio Biasiotto, Elio Scarpini, Silvana Archetti, Maura Cosseddu
Publikováno v:
Neurodegenerative Diseases. 16:172-178
Introduction: Brain iron homeostasis dysregulation has been widely related to neurodegeneration. In particular, human haemochromatosis protein (HFE) is involved in iron metabolism, and HFE H63D polymorphism has been related to the risk of amyotrophic
Autor:
Albert Lladó, José Luis Molinuevo, Alex Iranzo, Guadalupe Fernández-Villullas, Magda Castellví, Mircea Balasa, Anna Antonell, Lorena Rami, Beatriz Bosch, Oriol Grau-Rivera, Alba Sierra-Rio, Jaume Olives, Raquel Sánchez-Valle
Publikováno v:
Neurodegenerative Diseases. 16:69-76
Background: Determination of Alzheimer's disease (AD) by cerebrospinal fluid (CSF) biomarkers - 42-amino-acid amyloid-β (Aβ42), total tau and phosphorylated tau (p-tau) - has demonstrated high validity for detecting AD neuropathological changes. Ho
Autor:
José Luis Molinuevo, Domingo Escudero, Joaquim Oristrell, Laura Molina Porcel, Luis Brieva Ruiz, Marc Suárez-Calvet, Jordi Bruna, Josep Gamez, Jordi Diaz-Manera, Oriol Grau-Rivera, Raquel Sanchez-Valle, Francesc Graus, Elena Espejo
Publikováno v:
Neurodegenerative Diseases. 15:350-360
Background: Rapidly progressive dementia (RPD) is caused by a heterogeneous group of both neurodegenerative and non-neurodegenerative disorders. The presence of concomitant pathologies, mainly Alzheimer's disease (AD), may act as a confounding variab
Frontal Corpus Callosum Alterations in Progressive Supranuclear Palsy but Not in Parkinson's Disease
Autor:
Jan Kassubek, Elmar H. Pinkhardt, Albert C. Ludolph, Hans-Peter Müller, Hans-Jürgen Huppertz, Johannes Rosskopf
Publikováno v:
Neurodegenerative Diseases. 14:184-193
Background: Frontal lobe involvement is considered a clinical and magnetic resonance imaging (MRI) feature in later stages of progressive supranuclear palsy (PSP). Objective: Diffusion tensor imaging (DTI) was used to investigate the integrity of fro