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Autor:
René Hurlemann, Oliver Kaut, Tamara Schaprian, Thomas Klockgether, Marcus Grobe-Einsler, Ina R. Vogt
Publikováno v:
Neurodegenerative diseases 20(2-3), 104-109 (2020). doi:10.1159/000510057
Background: Rivastigmine is an acetylcholine esterase inhibitor which is commonly used as therapy for dementia in Alzheimer’s disease and Parkinson’s disease (PD). Recently, a randomized controlled trial demonstrated a positive effect of rivastig
Publikováno v:
Neurodegenerative Diseases. 19:238-243
Background: Multiple system atrophy (MSA) patients present a variety of symptoms other than autonomic dysfunctions, parkinsonism, and cerebellar ataxia. The aim of this study was to evaluate the frequency of various motor and non-motor symptoms inc
Autor:
Ramiro Álvarez, Anna Maria Fernàndez Planas, Dolores Vilas, Irina Isern, Lourdes Ispierto, Josep Sanchez, Josep De Haro, Albert Planas, Ane Miren Crespo Cuevas
Publikováno v:
Neurodegenerative Diseases. 18:143-149
Background: Olfactory dysfunction is common in Parkinson’s disease (PD). The characteristics of the hyposmia in PD have not been well defined. Objective: To characterize the pattern of the olfactory deficit in PD and in other non-neurodegenerative
Autor:
Woo Hyung Lee, Han Joon Kim, Tai Ryoon Han, Woong-Woo Lee, Seung Hak Lee, Yoon Jun Kim, Aryun Kim, Kwang Dong Kim, Han Gil Seo, Hyun Haeng Lee, Byung Mo Oh, Beomseok Jeon
Publikováno v:
Neurodegenerative Diseases. 18:84-90
Background/Aims: Dysphagia, a symptom of multiple system atrophy (MSA), is a major clinical concern. In this study, we investigate the characteristics of early oropharyngeal dysphagia (OD) in patients with MSA, and the differences between MSA subtype
Autor:
Narges Valizadeh, Hamid Reza Jahantigh, Houshang Rafatpanah, Asadollah Mohammadi, Samira Basharkhah, Seyed Abdolrahim Rezaee, Sayed-Hamidreza Mozhgani
Publikováno v:
Neurodegenerative Diseases. 18:150-155
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affect
Publikováno v:
Neurodegenerative Diseases. 17:181-198
Background/Aims: A novel ataxic mouse line was established from the offspring of a male mouse administered cyclophosphamide in a juvenile period. Methods: We have attempted to examine the phenotype and histopathological changes of affected mice. Furt
Autor:
Silvano Dragonieri, Mario Francesco Damiani, Alberto Capozzolo, Pierluigi Carratù, Onofrio Resta, Anna Cassano, Vitaliano Nicola Quaranta
Publikováno v:
Neurodegenerative Diseases. 17:14-21
Background/Objective: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of central and peripheral motor neurons. Some studies have found discordant data in the presence of sleep apnea in ALS pati
Autor:
Karin Srulijes, Matthis Synofzik, Cornelia Schatton, Jochen Klenk, Clemens Becker, Lars Schwickert, Walter Maetzler
Publikováno v:
Neurodegenerative diseases 16(5-6), 317-323 (2016). doi:10.1159/000444802
Background and Purpose: Reduced ambulatory activity is a major burden in neurodegenerative disease (NDD), leading to severe restrictions in social participation and further deterioration of motor capacities. However, objective evidence on walking beh
Autor:
Aytug Altundag, Murat Sonmez, Hakan Tekeli, Taner Kar, Yildiray Yildirim, Abdullah Kaya, Thomas Hummel, Melih Cayonu, Kadir Colakoglu
Publikováno v:
Neurodegenerative Diseases. 15:219-224
Background: Olfactory dysfunction is a common symptom of many neurodegenerative diseases, and age-related macular degeneration (AMD) is a late-onset neurodegenerative disease. Objective: Thus, the aim of this study was to investigate olfactory functi
Autor:
Ghil Jona, Vivian I. Teichberg, Itzik Cooper, Leonid Babakin, Angela Ruban, Katayun Cohen-Kashi Malina, Nadine Graubardt
Publikováno v:
Neurodegenerative Diseases. 15:233-242
Background/Aim: The sporadic form of the disease affects the majority of amyotrophic lateral sclerosis (ALS) patients. The role of glutamate (Glu) excitotoxicity in ALS has been extensively documented and remains one of the prominent hypotheses of AL