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Autor:
René Hurlemann, Oliver Kaut, Tamara Schaprian, Thomas Klockgether, Marcus Grobe-Einsler, Ina R. Vogt
Publikováno v:
Neurodegenerative diseases 20(2-3), 104-109 (2020). doi:10.1159/000510057
Background: Rivastigmine is an acetylcholine esterase inhibitor which is commonly used as therapy for dementia in Alzheimer’s disease and Parkinson’s disease (PD). Recently, a randomized controlled trial demonstrated a positive effect of rivastig
Autor:
Rita Nisticò, Andrea Quattrone, Paola Valentino, Aldo Quattrone, Franco Pucci, Alessia Sarica, Antonio Cerasa, Stefania Barone
Publikováno v:
Neurodegenerative diseases (Online) (2019). doi:10.1159/000503970
info:cnr-pdr/source/autori:Sarica A a, Valentino P c, Nisticò R b, Barone S c, Pucci F c, Quattrone A c, Cerasa A b, Quattrone A a,b/titolo:Assessment of the Corticospinal Tract Profile in Pure Lower Motor Neuron Disease: A Diffusion Tensor Imaging Study./doi:10.1159%2F000503970/rivista:Neurodegenerative diseases (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Sarica A a, Valentino P c, Nisticò R b, Barone S c, Pucci F c, Quattrone A c, Cerasa A b, Quattrone A a,b/titolo:Assessment of the Corticospinal Tract Profile in Pure Lower Motor Neuron Disease: A Diffusion Tensor Imaging Study./doi:10.1159%2F000503970/rivista:Neurodegenerative diseases (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Aim: The aim of this study was to evaluate the corticospinal tract (CST) diffusion profile in pure lower motor neuron disease (pLMND) patients who at baseline did not show any clinical or electrophysiological involvement of upper motor neurons (UMN),
Autor:
Yangyang Duan, Feng Wang, Fengting Zhang, Haining Li, Shaoqing Lin, Andy Li, Hui Li, Luxuan Wang, Guowei Wang
Publikováno v:
Neurodegenerative Diseases. 19:204-210
Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by intracellular α-synuclein (α-Syn) deposition. Alternation of the α-Syn expression level in plasma or erythrocytes may be used as a potential PD biomarker. Howev
Autor:
Woo Hyung Lee, Han Joon Kim, Tai Ryoon Han, Woong-Woo Lee, Seung Hak Lee, Yoon Jun Kim, Aryun Kim, Kwang Dong Kim, Han Gil Seo, Hyun Haeng Lee, Byung Mo Oh, Beomseok Jeon
Publikováno v:
Neurodegenerative Diseases. 18:84-90
Background/Aims: Dysphagia, a symptom of multiple system atrophy (MSA), is a major clinical concern. In this study, we investigate the characteristics of early oropharyngeal dysphagia (OD) in patients with MSA, and the differences between MSA subtype
Autor:
Wesley K. Thompson, Samuel Iddi, Michael C. Donohue, Irene Litvan, Dan Li, Michael S. Rafii, Paul S. Aisen
Publikováno v:
Neurodegenerative Diseases. 18:173-190
Parkinson’s disease is the second most common neurological disease and affects about 1% of persons over the age of 60 years. Due to the lack of approved surrogate markers, confirmation of the disease still requires postmortem examination. Identifyi
Autor:
Pilar Irún, Blanca Acha, Ivonne Jericó, Marina Oaia Iridoy, Maite Mendioroz, Arkaitz Galbete, Adriana Rivero, Miren Roldán, Cecilia Canosa, Leyre Martinez-Merino, Miguel Pocovi
Publikováno v:
Neurodegenerative Diseases. 18:208-215
Background: The development of biomarkers for use in diagnosing, monitoring disease progression and analyzing therapeutic trials response in amyotrophic lateral sclerosis (ALS) is essential. Objective: The aim of this study was to identify inflammato
Autor:
Narges Valizadeh, Hamid Reza Jahantigh, Houshang Rafatpanah, Asadollah Mohammadi, Samira Basharkhah, Seyed Abdolrahim Rezaee, Sayed-Hamidreza Mozhgani
Publikováno v:
Neurodegenerative Diseases. 18:150-155
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affect
Publikováno v:
Neurodegenerative Diseases. 18:165-172
Background: There are no reliable biomarkers that could evaluate the disease burden in amyotrophic lateral sclerosis (ALS). Objectives: The aim of our study is to evaluate the changes in cerebrospinal fluid (CSF) and serum neurofilament subunit L (NF
Autor:
Anna Losurdo, Anna Rita Bentivoglio, Federica Provini, Pietro Cortelli, Marcella Solito, Giovanna Calandra-Buonaura, Carla Piano, Claudio Imperatori, Giacomo Della Marca
Publikováno v:
Neurodegenerative Diseases. 17:330-337
Introduction: The aim of the study was to evaluate the clinical reliability of subjective sleep evaluation, based on sleep and psychometric questionnaires, by comparing the results with those obtained with laboratory-based video-polysomnography (V-PS
Autor:
Karin Srulijes, Matthis Synofzik, Cornelia Schatton, Jochen Klenk, Clemens Becker, Lars Schwickert, Walter Maetzler
Publikováno v:
Neurodegenerative diseases 16(5-6), 317-323 (2016). doi:10.1159/000444802
Background and Purpose: Reduced ambulatory activity is a major burden in neurodegenerative disease (NDD), leading to severe restrictions in social participation and further deterioration of motor capacities. However, objective evidence on walking beh