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Publikováno v:
Neurochemistry International. 128:21-31
Neovascular retinal diseases are the leading causes of blindness in advanced countries. To date, anti-VEGF (vascular endothelial growth factor) drugs are clinically effective and widely used for these diseases. However, recent animal and clinical stu
Publikováno v:
Neurochemistry International. 128:115-126
Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive dopaminergic neurodegeneration with a concomitant increase in oxidative stress and neuroinflammation in the substantia nigra pars compacta (SNc). Recent studi
Autor:
Predrag Kalaba, Jovana Maliković, Gert Lubec, Harish Vuyyuru, Volker Korz, Ahmed M. Hussein, Harald Koefeler, Roman Smidak, Harald Höger
Publikováno v:
Neurochemistry International. 128:215-221
There is growing evidence that lipids play a fundamental role in neuronal plasticity and learning and memory. Effects of nutrition on brain lipid composition and neuronal functioning are known, but the feeding interventions are often severe and may n
Publikováno v:
Neurochemistry International. 126:178-186
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition le
Autor:
Daniel Oppermann Peixoto, Juciano Gasparotto, Roberto Farina de Almeida, Alice Kunzler, Rafael Calixto Bortolin, Adriano Antunes de Souza Araújo, Pedro Ozorio Brum, Lucindo José Quintans-Júnior, Helen Tais da Rosa Silva, Daniel Pens Gelain, José Cláudio Fonseca Moreira, Lyvia Lintzmaier Petiz, Camila Tiefensee Ribeiro
Publikováno v:
Neurochemistry International. 126:27-35
Carvacrol (CARV) presents valuable biological properties such as anti-inflammatory and antioxidant activities. However, pharmacological uses of CARV are largely limited due to disadvantages related to solubility, bioavailability, preparation and stor
Autor:
Kentaro Yamaguchi, Kohei Man-yoshi, Hiroki Kurosaki, Shin-ichi Muramatsu, Hiroshi Ichinose, Satoshi Hara
Publikováno v:
Neurochemistry International. 125:16-24
Parkinson's disease (PD) is the second common neurodegenerative disorder. Deficit of the nigro-striatal dopaminergic neurons causes the motor symptoms of PD. While the oxidative stress is thought to be deeply involved in the etiology of PD, molecular
Autor:
N.N. Osborne, C. Núñez-Álvarez
Publikováno v:
Neurochemistry International. 125:187-196
Neurones are dependent on their mitochondria to produce the necessary amounts of ATP for survival. Retinal ganglion cells (RGCs) have a particularly large number of mitochondria which—unlike neurones in the brain—are exposed to visual light of 40
Autor:
C. S. Mota, José Cláudio Fonseca Moreira, Letícia Ferreira Pettenuzzo, Carla Dalmaz, Rachel Krolow, Carlos Eduardo Schnorr, Ana Paula Toniazzo, Danusa Mar Arcego, Camilla Lazzaretti
Publikováno v:
REDICUC-Repositorio CUC
Corporación Universidad de la Costa
instacron:Corporación Universidad de la Costa
Corporación Universidad de la Costa
instacron:Corporación Universidad de la Costa
Objective Some factors related to lifestyle, including stress and high-fat diet (HFD) consumption, are associated with higher prevalence of obesity. These factors can lead to an imbalance between ROS production and antioxidant defenses and to mitocho
Autor:
Zhengwei Li, Pian Gong, Xiaolin Wu, Yichun Zou, Xiang Li, Xiaohui Wu, Can Xin, Zhongwei Xiong, Qi Wan, Jianjian Zhang, Wenyuan Zhao, Jincao Chen
Publikováno v:
Neurochemistry International. 124:51-61
Piperine is the key bioactive factor in black pepper, and has been reported to alleviate cerebral ischemic injury. However, the mechanisms underlying its neuroprotective effects following cerebral ischemia remain unclear. In this study, rats were adm
Autor:
Tarsila Elizabeth Juárez-Zepeda, Leticia Granados-Rojas, Sandra Orozco-Suárez, Norma Serrano-García, Marisol Orozco-Ibarra, Francisca Fernández-Valverde, José Pedraza-Chaverri, Anabel Jiménez-Anguiano, Erika Rubí Luis-García
Publikováno v:
Neurochemistry International. 121:26-37
Rotenone, a classic mitochondrial complex I inhibitor, leads to dopaminergic neuronal death resulting in a Parkinson's-like-disease. Docosahexaenoic acid (DHA) has shown neuroprotective effects in other experimental models of Parkinson's disease, but