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Publikováno v:
Nephron Physiology. 116:p9-p16
Background/Aims: The plasma concentration of catecholamines and their metabolites generated by catechol-O-methyl transferase (COMT) were measured and their correlation with the progress of renal dysfunction was investigated in two distinctive animal
Autor:
Niroz Abu-Saleh, Joseph Winaver, Zaid Abassi, Michael K. Hansen, Elena Ovcharenko, Gino Miele, Giora Z. Feuerstein, Kathryn Walsh, Ilia Goltsman
Publikováno v:
Nephron Physiology. 115:p21-p30
Background/Aims: Patients treated with peroxisome proliferator-activated receptor analogs (PPAR) α or α/γ may develop a transient and reversible increase in serum creatinine, the mechanism of which remains obscure. This study evaluates whether tre
Autor:
Marcelo Roberto Choi, Brenda M. Lee, Alicia H. Correa, Belisario E. Fernández, Cecilia Medici
Publikováno v:
Nephron Physiology. 115:p1-p7
Background/Aims: Dopamine (DA) uptake inhibition in the renal cortex, elicited by angiotensin II (ANG II), is mediated by AT1 receptors and signals through the phospholipase C pathway and activation of protein kinase C and CaM-kinase II. By this indi
Autor:
María del Rosario Passalacqua, Mónica P. Majowicz, María F. Albertoni Borghese, Norma B. Sterin Speziale, María C. Ortiz, Norberto A. Vidal
Publikováno v:
Nephron Physiology. 112:p45-p52
Background/Aims: Diabetes mellitus may impact on the regulation of renal Na+-glucose cotransporter type 2 (SGLT2), however, previous studies have yielded conflicting results on the effects of streptozotocin (STZ)-induced diabetes on SGLT-mediated glu
Publikováno v:
Nephron Physiology. 109:p19-p27
Aims: In order to clarify the antinephritic mechanisms of saireito, the glucocorticoid receptor agonistic effect of saireito was evaluated in adrenalectomized rats with anti-glomerular basement membrane (anti-GBM) nephritis.Methods: Rats with anti-GB
Publikováno v:
Nephron Physiology, 103(1), 43-52
Background: Antiproteinuric treatment by ACE inhibition (ACEi) provides renoprotection. However, resistance to antiproteinuric intervention occurs frequently, resulting in progressive renal damage. The extent of renal damage prior to treatment with A
Autor:
Ana Lucia Mattar, Humberto Dellê, José Mauro Vieira, Roberto Zatz, Clarice Kazue Fujihara, L.T. Rodrigues, Denise Maria Avancini Costa Malheiros, I.L. Noronha, Eduardo Mantovani
Publikováno v:
Nephron Physiology. 101:p82-p91
Background: Several salutary biological effects of statins have been described. We sought to investigate more closely the anti-inflammatory and antiproliferative effects of simvastatin (SIMV) in a model of hypertension and progressive renal disease,
Autor:
Shai Efrati, Elena Galperin, M. Cohn, Sylvia Berman, Joshua Weissgarten, David Modai, Micha J. Rapoport, Mordechay Aladjem, Zhan Averbukh
Publikováno v:
Nephron Physiology. 101:p14-p20
Background/Aim: Hypertension induced by exaggerated sodium consumption accelerates the progression of renal failure. We investigated the effects of a high-sodium (HS) diet on the progression of renal failure in rats maintained normotensive by angiote
Autor:
Soo Wan Kim, Ile Kyu Park, Moon Hyang Park, Jong Un Lee, Seung Sam Paik, Ho-Sam Chung, Jun-Ho Ryu, Ho-Jung Kim, Doo Jin Paik, Sang-Woong Han
Publikováno v:
Nephron Physiology. 97:p58-p65
Aims: Effects of the blockade of renin-angiotensin system (RAS), by angiotensin-converting enzyme inhibitor (ACEi), type 1 angiotensin II receptor blocker (ARB), or a combination of both, were evaluated in Adriamycin (ADR)-induced glomerulopathy. Met
Autor:
Giovambattista Capasso, Francesco Morelli, Salvatore Metafora, F. Russo, Maria Rosaria Rizzo, Francesca Ciani
Publikováno v:
Nephron Physiology. 97:p16-p22
Background/Aims: Calbindin D28k has been reported to be involved in transcellular calcium transport along the rat distal convoluted tubule (DCT). It has also been shown that administration of bumetanide is associated with hypercalciuria. The experime