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Publikováno v:
Nephrology Dialysis Transplantation. 24:3319-3325
Background. Hypoxia plays an important role in kidney injury. By the stabilization of the transcription factor HIF-1, hypoxia affects gene expression also in tubular epithelial cells. Increased expression of connective tissue growth factor (CTGF) is
Publikováno v:
Nephrology, Dialysis, Transplantation, 23, 3397-402
Nephrology, Dialysis, Transplantation, 23, 11, pp. 3397-402
Nephrology, Dialysis, Transplantation, 23, 11, pp. 3397-402
Contains fulltext : 70822.pdf (Publisher’s version ) (Open Access) BACKGROUND: Active Ca(2+) reabsorption in the kidney is facilitated by the epithelial transient receptor potential vanilloid Ca(2+) channel subtype 5 (TRPV5). The complex-glycosylat
Publikováno v:
Nephrology Dialysis Transplantation. 24:755-762
Background Hepatocyte growth factor (HGF) is a pleiotropic protein with renoprotective functions, which have been attributed at least in part to its ability to counteract the profibrotic effects of transforming growth factor beta (TGF-beta). A major
Autor:
Veli-Matti Kähäri, Attila Fintha, Istvan Mucsi, Attila Sebe, László Rosivall, Suvi-Katri Leivonen, András Masszi
Publikováno v:
Nephrology Dialysis Transplantation. 23:1537-1545
Transforming growth factor-beta (TGFbeta)-induced epithelial-myofibroblast transdifferentiation is a central mechanism contributing to the pathogenesis of progressive tubulo-interstitial fibrosis. We wanted to dissect the role of extracellular signal
Autor:
Stéphane Burtey, Emilie Ribe, Marta Riera, Michel Fontes, Petra Pennekamp, Roselyne Rance, E. Passage, Bernd Dworniczak
Publikováno v:
Nephrology Dialysis Transplantation. 23:1157-1165
Polycystin-2 (PC-2), a cation channel of the Trp family, is involved in autosomal dominant polycystic kidney disease (ADPKD) type 2 (ADPKD2). This protein has recently been localized to the primary cilium where its channel function seems to be involv
Publikováno v:
Nephrology Dialysis Transplantation. 22:756-762
Background. Myofibroblastic conversion of mesothelial cells is proposed to play an important role in pathological changes following serosal membrane injury. Methods. Human peritoneal mesothelial cells (HPMCs) were isolated and maintained in culture.
Publikováno v:
Nephrology, Dialysis, Transplantation, 20, 864-867
Nephrology, Dialysis, Transplantation, 20, 5, pp. 864-7
Nephrology, Dialysis, Transplantation, 20, 864-7
Nephrology, Dialysis, Transplantation, 20, 5, pp. 864-867
Nephrology, Dialysis, Transplantation, 20, 5, pp. 864-7
Nephrology, Dialysis, Transplantation, 20, 864-7
Nephrology, Dialysis, Transplantation, 20, 5, pp. 864-867
Contains fulltext : 48616.pdf (Publisher’s version ) (Closed access)
Autor:
Boye L. Jensen, Ditte Andreasen, Ole Skøtt, Ulla G. Friis, Jeppe Schjerning, Pernille B. Lærkegaard Hansen, Torben Rene Uhrenholt
Publikováno v:
Nephrology Dialysis Transplantation. 19:1368-1373
Voltage-dependent calcium channels (Cav) play an important role in the excitation–contraction coupling in vascular smooth muscle by linking hormoneinduced depolarization to calcium influx and contraction. In keeping with this central role of Cav, t
Publikováno v:
Nephrology Dialysis Transplantation. 18:1689-1692
Autosomal dominant polycystic kidney disease results from loss-of-function mutations in either polycystin-1 (Pc-1) or polycystin-2 (Pc-2). These transmembrane proteins directly interact through cytosolic domains of their C-termini. Pc-1 has been impl
Publikováno v:
Nephrology Dialysis Transplantation. 17:42-49
Adhesion of monocytes triggers apoptosis, cytotoxicity, cytokine release, and later proliferation of cultured human mesangial cells (HMC). In the search for transmembrane signals transducing the interaction of HMC adhesion molecules with leukocyte co