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Publikováno v:
Nature Reviews Cancer. 13:511-518
The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is
Autor:
David Lyden, Bethan Psaila
Publikováno v:
Nature Reviews Cancer. 9:285-293
The ‘Seed and Soil’ hypothesis for metastasis sets forth the concept that a nutritive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept a
Publikováno v:
Nature Reviews Cancer. 2:826-835
Summary Tumours recruit neighbouring blood vessels and vascular endothelial cells to support their own blood supply. Recent evidence has indicated, however, that tumours are also capable of mobilizing bone-marrow-derived endothelial precursor cells,