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pro vyhledávání: '"Thomas Tuschl"'
Autor:
Thomas Tuschl, Yi Pei
Publikováno v:
Nature Methods. 3:670-676
Small interfering RNAs (siRNAs) have been widely exploited for sequence-specific gene knockdown, predominantly to investigate gene function in cultured vertebrate cells, and also hold promise as therapeutic agents. Because not all siRNAs that are cog
Autor:
Janos Ludwig, Sara H. Rouhanifard, Cindy Lim, John Pena, Cherin Sohn-Lee, Philipp Berninger, Markus Hafner, Aleksandra Mihailovic, Mihaela Zavolan, Thomas Tuschl, Daniel Holoch
Publikováno v:
Nature Methods. 6:139-141
MicroRNAs are small regulatory RNAs with many biological functions and disease associations. We showed that in situ hybridization (ISH) using conventional formaldehyde fixation results in substantial microRNA loss from mouse tissue sections, which ca
Autor:
Alain Sewer, Stewart Shuman, C. Kiong Ho, Mariana Lagos-Quintana, Robert L. Sheridan, David D. Ho, Viviana Simon, Charles M. Rice, Glenn Randall, Sébastien Pfeffer, Linda F. van Dyk, Friedrich A. Grässer, Minchen Chien, Brett D. Lindenbach, James J. Russo, Jingyue Ju, Thomas Tuschl, Chris Sander, Mihaela Zavolan
Publikováno v:
Nature methods. 2(4)
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs do not have close homologs in other viral genomes or in