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Autor:
Neill R. Graff-Radford, Caroline S. Widdowson, John Hardy, Simon Lovestone, Stefan Schreiber, Ana Frank-García, Amy Gerrish, Kevin Mayo, Alexandra Stretton, Michael John Owen, Minerva M. Carrasquillo, Seth Love, Jade Chapman, Vincent Chouraki, Monique M.B. Breteler, Francesco Panza, Emma R L C Vardy, Ronald C. Petersen, Harald Hampel, S. Nicolhaus, Lenore J. Launer, Michelle K. Lupton, Eckart Rüther, A. David Smith, David C. Rubinsztein, Rebecca Sims, Gill Livingston, Diana Zelenika, Simon Mead, Martin N. Rossor, Hilkka Soininen, Christine Van Broeckhoven, Kristel Sleegers, Thorlakur Jonsson, M. Arfan Ikram, Helen Beaumont, Michael Conlon O'Donovan, Federico Licastro, Sudha Seshadri, Alexander Richards, Nick C. Fox, Markus M. Nöthen, Claudine Berr, T. Feulner, Benedetta Nacmias, Carlos Cruchaga, Peter Passmore, Oscar L. Lopez, Julie Williams, Matthias Riemenschneider, Florence Pasquier, John Gallacher, Didier Hannequin, Sigrid Botne Sando, Jens Wiltfang, Charlene Thomas, Gabriele Siciliano, Maria Barcikowska, Mikko Hiltunen, Carol Brayne, Dobril Ivanov, Anita L. DeStefano, Bernadette McGuinness, Norman Klopp, Gordon K. Wilcock, Aoibhinn Lynch, Wolfgang Maier, Peter Holmans, H.-Erich Wichmann, Giorgio Annoni, Beatrice Arosio, Alison Goate, Sigurbjorn Bjornsson, Karl-Heinz Jöckel, Dan Rujescu, Hugh Gurling, Nigel M. Hooper, Clive Holmes, Andrew McQuillin, Patricia Friedrich, John Powell, Rhian Gwilliam, R. Heun, Jacques Epelbaum, Isabella Heuser, Magda Tsolaki, Dennis W. Dickson, Alberto Pilotto, Stephen Todd, Dominique Campion, Michael Krawczak, Jan O. Aasly, Olivier Hanon, Patrick G. Kehoe, Johannes Kornhuber, Marc Delepine, Peter Paul De Deyn, Britta Schürmann, Brian A. Lawlor, Christophe Tzourio, Richard Abraham, Petra Nowotny, Jean-François Dartigues, Heike Kölsch, Michelangelo Mancuso, Marian L. Hamshere, Zbigniew K. Wszolek, Paola Piccardi, Paolo Bosco, Jean-Charles Lambert, Denise Harold, Frank Jessen, Palmi V. Jonsson, Paola Bossù, Paul Hollingworth, Jon Snaedal, Michael Gill, Onofre Combarros, David M. A. Mann, John C. Morris, Annette L. Fitzpatrick, Christopher Shaw, Alexis Brice, Philippe Amouyel, Elio Scarpini, Lesley Jones, Sebastiaan Engelborghs, Daniela Galimberti, Vincenzo Solfrizzi, V. Shane Pankratz, John Collinge, María J. Bullido, Kristelle Brown, Nicholas Bass, Andrew B. Singleton, Jaspreet Singh Pahwa, Kari Stefansson, Lutz Frölich, Steven G. Younkin, Ignacio Mateo, Annick Alpérovitch, Benjamin Genier-Boley, Ina Giegling, Caterina Riehle, Kimberley Dowzell, Mark Lathrop, Hreinn Stefansson, Sandro Sorbi, Rita Guerreiro, Thomas W. Mühleisen, Karolien Bettens, Michael Hüll, Martin Dichgans, Petroula Proitsi, Panagiotis Deloukas, Valentina Moskvina, Cornelia M. van Duijn, Donald Warden, Victoria Alvarez, Eliecer Coto, Kevin Morgan, Susanne Moebus, Ammar Al-Chalabi, Elisa Porcellini, Stefan Wagenpfeil, Hendrik van den Bussche, John S. K. Kauwe, Stacy Steinberg, David Craig, Nicola Jones, Manuel Mayhaus, Davide Seripa
Publikováno v:
Nature genetics 43(5), 429-435 (2011). doi:10.1038/ng.803
Nature Genetics, 43(5), 429-435. Nature Publishing Group
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J-C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruether, E, Schuermann, B, Heun, R, Koelsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Gallacher, J, Huell, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J-F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature genetics
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, Van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-35 . https://doi.org/10.1038/ng.803
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W & Graff-Radford, N R A O 2011, ' Common Variants at Abca7, Ms4A6A/Ms4A4E, Epha1, Cd33 and Cd2Ap Are Associated with Alzheimer'S Disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature Genetics, 43(5), 429-435. Nature Publishing Group
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J-C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruether, E, Schuermann, B, Heun, R, Koelsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Froelich, L, Hampel, H, Gallacher, J, Huell, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muehleisen, T W, Noethen, M M, Moebus, S, Joeckel, K-H, Klopp, N, Wichmann, H-E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J-F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
Nature genetics
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, Van Den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, De Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W, Graff-Radford, N R, Petersen, R C, Van Duijn, C M, Breteler, M M B, Ikram, M A, DeStefano, A L, Fitzpatrick, A L, Lopez, O, Launer, L J, Seshadri, S, Berr, C, Campion, D, Epelbaum, J, Dartigues, J F, Tzourio, C, Alperovitch, A, Lathrop, M, Feulner, T M, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Bjornsson, S, Jonsson, P V, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, M J, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossu, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, P A, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, S G, Owen, M J, O'Donovan, M, Amouyel, P & Williams, J 2011, ' Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease ', Nature Genetics, vol. 43, no. 5, pp. 429-35 . https://doi.org/10.1038/ng.803
Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J C, Carrasquillo, M M, Abraham, R, Hamshere, M L, Pahwa, J S, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, M K, Brayne, C, Rubinsztein, D C, Gill, M, Lawlor, B, Lynch, A, Brown, K S, Passmore, P A, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, A D, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, P G, Hooper, N M, Vardy, E R L C, Hardy, J, Mead, S, Fox, N C, Rossor, M, Collinge, J, Maier, W, Jessen, F, Ruther, E, Schurmann, B, Heun, R, Kolsch, H, van den Bussche, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frolich, L, Hampel, H, Gallacher, J, Hull, M, Rujescu, D, Giegling, I, Goate, A M, Kauwe, J S K, Cruchaga, C, Nowotny, P, Morris, J C, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, de Deyn, P P, Van Broeckhoven, C, Livingston, G, Bass, N J, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C E, Tsolaki, M, Singleton, A B, Guerreiro, R, Muhleisen, T W, Nothen, M M, Moebus, S, Jockel, K H, Klopp, N, Wichmann, H E, Pankratz, V S, Sando, S B, Aasly, J O, Barcikowska, M, Wszolek, Z K, Dickson, D W & Graff-Radford, N R A O 2011, ' Common Variants at Abca7, Ms4A6A/Ms4A4E, Epha1, Cd33 and Cd2Ap Are Associated with Alzheimer'S Disease ', Nature Genetics, vol. 43, no. 5, pp. 429-435 . https://doi.org/10.1038/ng.803
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combin
Autor:
Chia R; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Sabir MS; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Bandres-Ciga S; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Saez-Atienzar S; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Reynolds RH; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Gustavsson E; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Walton RL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ahmed S; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Viollet C; Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Ding J; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Makarious MB; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Diez-Fairen M; Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain., Portley MK; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Shah Z; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Abramzon Y; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK., Hernandez DG; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Blauwendraat C; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Stone DJ; Cerevel Therapeutics, Boston, MA, USA., Eicher J; Genetics and Pharmacogenomics, Merck & Co., Inc., West Point, PA, USA., Parkkinen L; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Ansorge O; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Clark L; Taub Institute for Alzheimer Disease and the Aging Brain, and Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Honig LS; Taub Institute for Alzheimer Disease and the Aging Brain, G. H. Sergievsky Center and Department of Neurology, Columbia University, New York, NY, USA., Marder K; Taub Institute for Alzheimer Disease and the Aging Brain, G. H. Sergievsky Center and Department of Neurology, Columbia University, New York, NY, USA., Lemstra A; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands., St George-Hyslop P; Department of Clinical Neurosciences, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Londos E; Clinical Memory Research Unit, Institution of Clinical Sciences Malmo, Lund University, Lund, Sweden., Morgan K; Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK., Lashley T; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Warner TT; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Jaunmuktane Z; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Galasko D; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA., Santana I; Neurology Service, University of Coimbra Hospital, Coimbra, Portugal.; Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Tienari PJ; Translational Immunology, Research Programs Unit, University of Helsinki, Helsinki, Finland.; Department of Neurology, Helsinki University Hospital, Helsinki, Finland., Myllykangas L; 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Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grassano M; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy., Calvo A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Mora G; Istituti Clinici Scientifici Maugeri, IRCCS, Milan, Italy., Canosa A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Floris G; Department of Neurology, University Hospital of Cagliari, Cagliari, Italy., Bohannan RC; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA., Brett F; Dublin Brain Bank, Neuropathology Department, Beaumont Hospital, Dublin, Ireland., Gan-Or Z; Montreal Neurological Institute and Hospital, Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada., Geiger JT; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Moore A; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., May P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Krüger R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Goldstein DS; Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Lopez G; 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Department of Neurodegenerative Diseases, Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases, Tübingen, Germany., Landi F; Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy., Salvi E; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Cusi D; Bio4Dreams-Business Nursery for Life, Milan, Italy., Masliah E; Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Kim RC; Department of Neuropathology, School of Medicine, University of California Irvine, Irvine, CA, USA., Caraway CA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA., Monuki ES; Department of Pathology & Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA., Brunetti M; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy., Dawson TM; 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Snyder Department of Neuroscience, Johns Hopkins University Medical Center, Baltimore, MD, USA., Rosenthal LS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Albert MS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Pletnikova O; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.; Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Troncoso JC; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA., Flanagan ME; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mao Q; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bigio EH; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rodríguez-Rodríguez E; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Infante J; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Lage C; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., González-Aramburu I; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Sanchez-Juan P; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Keith J; Department of Anatomical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Black SE; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Masellis M; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; Cognitive & Movement Disorders Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Duyckaerts C; Department of Neuropathology Escourolle, Paris Brain Institute, Sorbonne Universités, Paris, France.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Brice A; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Lesage S; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Xiromerisiou G; Department of Neurology, University Hospital of Larissa, University of Thessalia, Larissa, Greece., Barrett MJ; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA., Tilley BS; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK., Gentleman S; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK., Logroscino G; Department of Basic Medicine Neurosciences and Sense Organs, University Aldo Moro, Bari, Italy.; Center for Neurodegenerative Diseases and the Aging Brain - Department of Clinical Research in Neurology of the University of Bari at 'Pia Fondazione Card G. Panico' Hospital Tricase (Le), Bari, Italy., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., McKeith IG; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Thomas AJ; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Attems J; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Morris CM; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Palmer L; South West Dementia Brain Bank, Bristol Medical School, University of Bristol, Bristol, UK., Love S; Dementia Research Group, Bristol Medical School, University of Bristol, Bristol, UK., Troakes C; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Al-Sarraj S; Department of Clinical Neuropathology and London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College Hospital and King's College London, London, UK., Hodges AK; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Aarsland D; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway., Klein G; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA., Kaiser SM; Department of Neuropathology, Indiana University School of Medicine, Indianapolis, IN, USA., Woltjer R; Department of Neurology, Oregon Health & Sciences University, Portland, OR, USA., Pastor P; Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain., Bekris LM; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA., Leverenz JB; Cleveland Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA., Besser LM; Institute for Human Health and Disease Intervention, Florida Atlantic University, Boca Raton, FL, USA., Kuzma A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Renton AE; Ronald M. Loeb Center for Alzheimer's Disease, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Nash Family Department of Neuroscience, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA., Scherzer CR; Precision Neurology Program, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Morris HR; Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK., Ferrari R; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Albani D; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Faber K; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA, USA., Morenas-Rodriguez E; Biomedizinisches Centrum, Biochemie, Ludwig-Maximilians-Universität München & Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Lleó A; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Fortea J; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Alcolea D; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Clarimon J; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Ferrucci L; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA., Tanaka T; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ferman T; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Hardy JA; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute of UCL, UCL Institute of Neurology, University College London, London, UK.; UCL Movement Disorders Centre, University College London, London, UK.; Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Topol EJ; Scripps Research Translational Institute, Scripps Research, La Jolla, CA, USA., Torkamani A; Scripps Research Translational Institute, Scripps Research, La Jolla, CA, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Ryten M; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chiò A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.; Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, USA., Gibbs JR; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Scholz SW; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. sonja.scholz@nih.gov.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA. sonja.scholz@nih.gov.
Publikováno v:
Nature genetics [Nat Genet] 2021 Mar; Vol. 53 (3), pp. 294-303. Date of Electronic Publication: 2021 Feb 15.
Autor:
Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Sims R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Damotte V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Boland A; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Vronskaya M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Amlie-Wolf A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Frizatti A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chouraki V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Badarinarayan N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Olaso R; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Raybould R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Morgan T; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Garnier JG; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Moutet ML; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Gerrish A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bacq D; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Denning N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Del Zompo M; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Fox NC; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Choi SH; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Dombroski BA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Daniilidou M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Wallon D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Garzia F; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Butkiewicz M; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Fin B; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Scarpini E; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bush WS; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Meslage S; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., White CC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Engelborghs S; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Sordon S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Voijnovic D; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., De Deyn PP; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Himali JJ; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Orellana A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Blacker D; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Rodriguez-Rodriguez E; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA., Munoz-Fernadez C; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA., Thonberg H; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Roshchupkin G; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Giedraitis V; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Kawalia A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kilander L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Hernández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Kamboh MI; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Brundin R; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Concari L; Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.; FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Beiser AS; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA., Helisalmi S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Koivisto AM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Lynch A; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lawlor B; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy., Gill M; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Frisardi V; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Diez-Fairen M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Deramecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Alvarez I; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Salani F; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Ciaramella A; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA., Fievet N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanon O; University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Uitterlinden AGA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Royall DR; Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA., Dufouil C; University of Bordeaux, Inserm 1219, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., de Rojas I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Sano M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brice A; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., George-Hyslop PS; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Ritchie K; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France.; Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsolaki M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsuang DW; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.; Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Wu CK; Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA., Soininen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Avramidou D; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Fratiglioni L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Germanou A; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Koutroumani M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Panza F; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Gkatzima O; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Hannequin D; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Atwood CS; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Caffarra P; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hampel H; AXA Research Fund & Sorbonne University Chair, Paris, France.; Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Carracedo Á; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Lannfelt L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pasquier F; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Frölich L; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA., Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Becker JT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Bird TD; Department of Neurology, University of Washington, Seattle, WA, USA.; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA., Warren JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Bowen JD; Swedish Medical Center, Seattle, WA, USA., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Powell JF; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Burke JR; Department of Neurology, Duke University, Durham, NC, USA., Kauwe JSK; Departments of Biology, Brigham Young University, Provo, UT, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Livingston G; Division of Psychiatry, University College London, London, UK., Carlson CS; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Bass NJ; Division of Psychiatry, University College London, London, UK., Carlsson CM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Carney RM; Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA., Bras J; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Guerreiro R; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Fisher E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Bisceglio G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Ma L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Faber KM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Farlow MR; Department of Neurology, Indiana University, Indianapolis, IN, USA., Kölsch H; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Ferris S; Department of Psychiatry, New York University, New York, NY, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Foroud TM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Heuser I; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA., Hüll M; Department of Psychiatry, University of Freiburg, Freiburg, Germany., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mayo K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA.; Department of Genetics, Washington University, St. Louis, MO, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Feulner T; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Drichel D; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Cushion TD; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Hollingworth P; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hulette CM; Department of Pathology, Duke University, Durham, NC, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Marshall R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Meggy A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Menzies GE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jin LW; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Leonenko G; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Baldwin CT; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Grozeva D; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Karydas A; Swedish Medical Center, Seattle, WA, USA., Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, OR, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Kowall NW; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., Vellas B; Inserm U558, University of Toulouse, Toulouse, France., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA., Vardy E; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Lah JJ; Department of Neurology, Emory University, Atlanta, GA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA., Mann D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Levey AI; Department of Neurology, Emory University, Atlanta, GA, USA., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klopp N; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wichmann HE; Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.; Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.; Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Morgan K; Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, NY, USA., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mash DC; Department of Neurology, University of Miami, Miami, FL, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Hooper NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McCormick WC; Department of Medicine, University of Washington, Seattle, WA, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA., Bayer A; Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK., McDavid AN; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Gallacher J; Department of Psychiatry, University of Oxford, Oxford, UK., McKee AC; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., van den Bussche H; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Mesulam M; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brayne C; Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK., Miller BL; Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Miller CA; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA., Shaw CE; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases, Goettingen, Germany.; IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal., O'Bryant S; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Perry WR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Rossor M; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Pierce A; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Ryan NS; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Quinn JF; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Sacchinelli E; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Caltagirone C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Bossù P; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Orfei MD; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Reisberg B; Department of Psychiatry, New York University, New York, NY, USA.; Alzheimer's Disease Center, New York University, New York, NY, USA., Clarke R; Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK., Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Epidemiology, Columbia University, New York, NY, USA., Smith AD; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Ringman JM; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA., Warden D; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Wilcock G; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sager MA; Department of Medicine, University of Wisconsin, Madison, WI, USA., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Saykin AJ; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, CA, USA.; Department of Psychiatry, University of Southern California, Los Angeles, CA, USA., Slifer S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, WA, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Stern RA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Tang M; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Troncoso JC; 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Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University, Atlanta, GA, USA., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Wright CB; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Yu CE; Department of Medicine, University of Washington, Seattle, WA, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Pilotto A; Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy., Bullido MJ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Peters O; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; German Center for Neurodegenerative Diseases, Berlin, Germany., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Bennett D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bosco P; Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy., Coto E; 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The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Graff C; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Gwilliam R; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. 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Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., Corcoran C; Utah State University, Logan, UT, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nicolas G; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Campion D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.; Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France., Tschanz J; Utah State University, Logan, UT, USA., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.; Department of Neurology, Medical University Graz, Graz, Austria., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Munger R; Utah State University, Logan, UT, USA., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria., Farrer LA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Van Broeckhoven C; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., O'Donovan MC; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., DeStefano AL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jones L; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Haines JL; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Owen MJ; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Escott-Price V; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Holmans PA; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Williams J; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Lille, France., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.
Publikováno v:
Nature genetics [Nat Genet] 2019 Sep; Vol. 51 (9), pp. 1423-1424.
Autor:
Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Sims R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Damotte V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Boland A; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Vronskaya M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Amlie-Wolf A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Frizatti A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chouraki V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Badarinarayan N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Olaso R; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Raybould R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Morgan T; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Garnier JG; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Moutet ML; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Gerrish A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bacq D; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Denning N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Del Zompo M; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Fox NC; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Choi SH; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Dombroski BA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Daniilidou M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Wallon D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Garzia F; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Butkiewicz M; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Fin B; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Scarpini E; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bush WS; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Meslage S; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., White CC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Engelborghs S; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Sordon S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Voijnovic D; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., De Deyn PP; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Himali JJ; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Orellana A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Blacker D; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Rodriguez-Rodriguez E; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA., Munoz-Fernadez C; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA., Thonberg H; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Roshchupkin G; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Giedraitis V; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Kawalia A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kilander L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Hernández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Kamboh MI; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Brundin R; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Concari L; Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.; FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Beiser AS; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA., Helisalmi S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Koivisto AM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Lynch A; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lawlor B; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy., Gill M; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Frisardi V; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Diez-Fairen M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Deramecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Alvarez I; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Salani F; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Ciaramella A; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA., Fievet N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanon O; University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Andre Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Royall DR; Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA., Dufouil C; University of Bordeaux, Inserm 1219, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., de Rojas I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Sano M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brice A; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., George-Hyslop PS; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Ritchie K; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France.; Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsolaki M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsuang DW; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.; Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Wu CK; Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA., Soininen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Avramidou D; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Fratiglioni L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Germanou A; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Koutroumani M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Panza F; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Gkatzima O; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Hannequin D; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Atwood CS; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Caffarra P; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hampel H; AXA Research Fund & Sorbonne University Chair, Paris, France.; Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Carracedo Á; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Lannfelt L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pasquier F; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Frölich L; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA., Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Becker JT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Bird TD; Department of Neurology, University of Washington, Seattle, WA, USA.; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA., Warren JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Bowen JD; Swedish Medical Center, Seattle, WA, USA., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Powell JF; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Burke JR; Department of Neurology, Duke University, Durham, NC, USA., Kauwe JSK; Departments of Biology, Brigham Young University, Provo, UT, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Livingston G; Division of Psychiatry, University College London, London, UK., Carlson CS; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Bass NJ; Division of Psychiatry, University College London, London, UK., Carlsson CM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Carney RM; Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA., Bras J; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Guerreiro R; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Fisher E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Bisceglio G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Ma L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Faber KM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Farlow MR; Department of Neurology, Indiana University, Indianapolis, IN, USA., Kölsch H; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Ferris S; Department of Psychiatry, New York University, New York, NY, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Foroud TM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Heuser I; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA., Hüll M; Department of Psychiatry, University of Freiburg, Freiburg, Germany., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mayo K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA.; Department of Genetics, Washington University, St. Louis, MO, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Feulner T; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Drichel D; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Cushion TD; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Hollingworth P; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hulette CM; Department of Pathology, Duke University, Durham, NC, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Marshall R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Meggy A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Menzies GE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jin LW; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Leonenko G; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Baldwin CT; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Grozeva D; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Karydas A; Swedish Medical Center, Seattle, WA, USA., Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, OR, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Kowall NW; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., Vellas B; Inserm U558, University of Toulouse, Toulouse, France., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA., Vardy E; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Lah JJ; Department of Neurology, Emory University, Atlanta, GA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA., Mann D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Levey AI; Department of Neurology, Emory University, Atlanta, GA, USA., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klopp N; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wichmann HE; Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.; Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.; Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Morgan K; Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, NY, USA., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mash DC; Department of Neurology, University of Miami, Miami, FL, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Hooper NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McCormick WC; Department of Medicine, University of Washington, Seattle, WA, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA., Bayer A; Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK., McDavid AN; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Gallacher J; Department of Psychiatry, University of Oxford, Oxford, UK., McKee AC; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., van den Bussche H; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Mesulam M; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brayne C; Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK., Miller BL; Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Miller CA; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA., Shaw CE; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases, Goettingen, Germany.; IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal., O'Bryant S; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Perry WR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Rossor M; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Pierce A; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Ryan NS; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Quinn JF; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Sacchinelli E; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Caltagirone C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Bossù P; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Orfei MD; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Reisberg B; Department of Psychiatry, New York University, New York, NY, USA.; Alzheimer's Disease Center, New York University, New York, NY, USA., Clarke R; Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK., Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Epidemiology, Columbia University, New York, NY, USA., Smith AD; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Ringman JM; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA., Warden D; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Wilcock G; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sager MA; Department of Medicine, University of Wisconsin, Madison, WI, USA., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Saykin AJ; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, CA, USA.; Department of Psychiatry, University of Southern California, Los Angeles, CA, USA., Slifer S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, WA, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Stern RA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Tang M; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA., Weintraub S; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Welsh-Bohmer KA; Department of Neurology, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University, Atlanta, GA, USA., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Wright CB; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Yu CE; Department of Medicine, University of Washington, Seattle, WA, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Pilotto A; Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy., Bullido MJ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Peters O; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; German Center for Neurodegenerative Diseases, Berlin, Germany., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Bennett D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bosco P; Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boccardi V; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Lleo A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Warner N; Somerset Partnership NHS Trust, Somerset, UK., Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Ingelsson M; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Deloukas P; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Graff C; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Gwilliam R; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sanchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Kehoe PG; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Berr C; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France., Debette S; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Love S; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., Corcoran C; Utah State University, Logan, UT, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nicolas G; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Campion D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.; Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France., Tschanz J; Utah State University, Logan, UT, USA., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.; Department of Neurology, Medical University Graz, Graz, Austria., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Munger R; Utah State University, Logan, UT, USA., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria., Farrer LA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Van Broeckhoven C; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., C O'Donovan M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., DeStefano AL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jones L; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Haines JL; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Owen MJ; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Escott-Price V; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Holmans PA; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Williams J; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Lille, France., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.
Publikováno v:
Nature genetics [Nat Genet] 2019 Mar; Vol. 51 (3), pp. 414-430. Date of Electronic Publication: 2019 Feb 28.
Autor:
Sims R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Bellenguez C; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Badarinarayan N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Boland A; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Raybould R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Grenier-Boley B; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Chouraki V; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Vronskaya M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Graham RR; Immunology Biomarkers Group, Genentech, South San Francisco, California, USA., Olaso R; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Grove ML; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., White CC; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France., Maier W; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Choi SH; Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Dulary C; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Herms S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Funk CC; Institute for Systems Biology, Seattle, Washington, USA., Derbois C; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Forstner AJ; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Li H; Institute for Systems Biology, Seattle, Washington, USA., Bacq D; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Satizabal CL; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Thomas R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Sánchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain., Morgan T; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Wolters FJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Garcia FS; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Denning N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Majounie E; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Dombroski B; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Wallon D; Centre Hospitalier du Rouvray, Sotteville les Rouen, France.; INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Fratiglioni L; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, Washington, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Panza F; Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy., McGuinness B; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Burgess JD; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Solfrizzi V; Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Seripa D; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Pastor P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Cupples LA; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Price ND; Institute for Systems Biology, Seattle, Washington, USA., Hannequin D; INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France.; Department of Neurology, Rouen University Hospital, Rouen, France., Frank-García A; Department of Neurology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Levy D; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA., Chakrabarty P; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA., Caffarra P; Department of Neuroscience, University of Parma, Parma, Italy.; Center for Cognitive Disorders AUSL, Parma, Italy., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Beiser AS; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Giedraitis V; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Hampel H; AXA Research Fund and UPMC Chair, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Paris, France.; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA., Wang X; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Lannfelt L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Crane PK; Department of Medicine, University of Washington, Seattle, Washington, USA., Pasquier F; Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France.; INSERM UMRS 1171, CNR-Maj, Lille, France., Boccardi V; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Henández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Emilsson V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Braae A; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Blacker D; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Schmidt H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA., Spalletta G; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA., Bossù P; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Sacchinelli E; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Kamboh MI; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA., Sotolongo-Grau O; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Corcoran C; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Dunstan M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Braddel A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Thomas C; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Meggy A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Marshall R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gerrish A; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chapman J; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Aguilar M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Unit, Department of Neurology, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain., Taylor S; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hill M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Fairén MD; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Vellas B; INSERM U558, University of Toulouse, Toulouse, France., Soininen H; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Daniilidou M; Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Fenoglio C; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Serpente M; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Arcaro M; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Caltagirone C; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Orfei MD; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Ciaramella A; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Pichler S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Lleó A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Fortea J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Blesa R; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Barber IS; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Brookes K; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Carrell D; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Sorbi S; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Urbano M; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Pilotto A; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., Bosco P; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy., Todd S; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Craig D; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Johnston J; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Gill M; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lawlor B; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lynch A; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Fox NC; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Atwood CS; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Baldwin CT; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bird TD; Department of Neurology, University of Washington, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Bowen JD; Swedish Medical Center, Seattle, Washington, USA., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Burke JR; Department of Medicine, Duke University, Durham, North Carolina, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Buxbaum JD; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Carlson CS; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Carlsson CM; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Carney RM; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Diaz CC; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, California, USA., Clark DG; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Neurology, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, California, USA., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, California, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA., Farlow MR; Department of Neurology, Indiana University, Indianapolis, Indiana, USA., Ferris S; Department of Psychiatry, New York University, New York, New York, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia, USA., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA., Hulette CM; Department of Pathology, Duke University, Durham, North Carolina, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA., Jin LW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Jun G; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University, Boston, Massachusetts, USA., Karydas A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA., Kowall NW; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Kramer JH; Department of Neuropsychology, University of California, San Francisco, San Francisco, California, USA., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA., Lah JJ; Department of Neurology, Emory University, Atlanta, Georgia, USA., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA., Levey AI; Department of Neurology, Emory University, Atlanta, Georgia, USA., Li G; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Lunetta KL; Department of Biostatistics, Boston University, Boston, Massachusetts, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, New York, USA., Mash DC; Department of Neurology, University of Miami, Miami, Florida, USA., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Department of Pathology, University of California, San Diego, La Jolla, California, USA., McCormick WC; Department of Medicine, University of Washington, Seattle, Washington, USA., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA., McDavid AN; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., McKee AC; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Mesulam M; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Miller CA; Department of Pathology, University of Southern California, Los Angeles, California, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.; Department of Neurology, Washington University, St. Louis, Missouri, USA., Murrell JR; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., O'Bryant S; Internal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, California, USA., Pankratz VS; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Perry W; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Pierce A; Department of Neurology, University of California, Irvine, Irvine, California, USA., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA., Quinn JF; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Reisberg B; Department of Psychiatry, New York University, New York, New York, USA.; Alzheimer's Disease Center, New York University, New York, New York, USA., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA., Ringman JM; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sager MA; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA., Saykin AJ; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, California, USA.; Department of Psychiatry, University of Southern California, Los Angeles, California, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, Washington, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA., Stern RA; Department of Neurology, Boston University, Boston, Massachusetts, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Thornton-Wells TA; Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA., Weintraub S; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Welsh-Bohmer KA; Department of Medicine, Duke University, Durham, North Carolina, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, Georgia, USA., Woltjer RL; Department of Pathology, Oregon Health &Science University, Portland, Oregon, USA., Wright CB; Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA., Yu CE; Department of Medicine, University of Washington, Seattle, Washington, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Garzia F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Golamaully F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Septier G; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Engelborghs S; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Vandenberghe R; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.; Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium., De Deyn PP; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Fernadez CM; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Thonberg H; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Forsell C; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Lilius L; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kinhult-Stählbom A; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kilander L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Brundin R; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Concari L; Department of Neuroscience, University of Parma, Parma, Italy.; Center for Cognitive Disorders AUSL, Parma, Italy., Helisalmi S; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Koivisto AM; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Haapasalo A; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Dermecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Fievet N; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Hanon O; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Dufouil C; University of Bordeaux, Neuroepidemiology, Bordeaux, France.; INSERM, Neuroepidemiology, UMR 897, Bordeaux, France., Brice A; INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Ritchie K; INSERM U1061, La Colombière Hospital, Montpellier, France., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; Institut des Neurosciences Translationnelles de Paris (IHU-A-ICM), Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; INSERM, CNRS, UMRS 975, Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Himali JJ; Boston University School of Medicine, Boston, Massachusetts, USA., Keene CD; Department of Pathology, University of Washington, Seattle, Washington, USA., Tschanz J; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Fitzpatrick AL; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Family Medicine, University of Washington, Seattle, Washington, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Norton M; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Larson EB; Department of Medicine, University of Washington, Seattle, Washington, USA.; Group Health Research Institute, Group Health, Seattle, Washington, USA., Munger R; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Bullido MJ; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Montine TJ; Department of Pathology, University of Washington, Seattle, Washington, USA., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.; Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.; Banner Alzheimer's Institute, Phoenix, Arizona, USA.; Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., O'Donnell CJ; Framingham Heart Study, Framingham, Massachusetts, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Royall DR; Departments of Psychiatry, Medicine, and Family and Community Medicine and South Texas Veterans Health Administration Geriatric Research Education and Clinical Center (GRECC), University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Sano M; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Galimberti D; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., St George-Hyslop P; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Scarpini E; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Tsuang DW; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Winslow AR; PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., Wu CK; Departments of Neurology, Pharmacology, and Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA., Peters O; Department of Psychiatry, Charité University Medicine, Berlin, Germany., Nacmias B; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Brayne C; Institute of Public Health, University of Cambridge, Cambridge, UK., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Bras J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Guerreiro R; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Shaw CE; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Mann D; Institute of Brain, Behaviour and Mental Health, Clinical and Cognitive Neuroscience Research Group, University of Manchester, Manchester, UK., Tsolaki M; 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Clarimón J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lovestone S; 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VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA., Ingelsson M; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Bennett DA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Powell J; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Golde TE; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.; Florida Alzheimer's Disease Research Center, Gainesville, Florida, USA., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA., Morgan K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Combarros O; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; 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Publikováno v:
Nature genetics [Nat Genet] 2017 Sep; Vol. 49 (9), pp. 1373-1384. Date of Electronic Publication: 2017 Jul 17.
Autor:
Naj AC; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD
Publikováno v:
Nature genetics [Nat Genet] 2011 May; Vol. 43 (5), pp. 436-41. Date of Electronic Publication: 2011 Apr 03.
Autor:
Hollingworth P; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK., Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J
Publikováno v:
Nature genetics [Nat Genet] 2011 May; Vol. 43 (5), pp. 429-35. Date of Electronic Publication: 2011 Apr 03.
Autor:
Van Deerlin VM; [1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work., Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL 3rd, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM
Publikováno v:
Nature genetics [Nat Genet] 2010 Mar; Vol. 42 (3), pp. 234-9. Date of Electronic Publication: 2010 Feb 14.