Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Whitworth, A. P."'
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-termina
Externí odkaz:
https://doaj.org/article/d00c6a73922e4ae69223e5ddad630fd5
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7
Autor:
Joshua N. Jones, Sarah J. Boulton, Martin Stokes, Georgina L. Bennett, Michael R. Z. Whitworth
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Significant mass-wasting perturbations can be caused by 5–30 year return period extreme rainfall and by earthquake induced landscape preconditioning damage.
Externí odkaz:
https://doaj.org/article/b6fc200ec84b425dae215a17c847af67
Autor:
Alasdair D. Henderson, Mike Kama, Maite Aubry, Stephane Hue, Anita Teissier, Taina Naivalu, Vinaisi D. Bechu, Jimaima Kailawadoko, Isireli Rabukawaqa, Aalisha Sahukhan, Martin L. Hibberd, Eric J. Nilles, Sebastian Funk, Jimmy Whitworth, Conall H. Watson, Colleen L. Lau, W. John Edmunds, Van-Mai Cao-Lormeau, Adam J. Kucharski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Dengue and Zika virus are closely related flaviviruses but can have contrasting transmission dynamics in the same populations. Here, the authors use a model combining serological, surveillance and viral sequence data to explain differences in transmi
Externí odkaz:
https://doaj.org/article/8a5363465454474ab1bd7ba14788c153
Akademický článek
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Autor:
Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has
Externí odkaz:
https://doaj.org/article/f090eaf1785247208a099d9f6a996bb3
Autor:
Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The RNA for ALS- and frontotemporal dementia-associated C9ORF72 gene is exported from nucleus via an unknown mechanism. This study shows that reduction of nuclear export adaptor SRSF1 can alleviate neuronal cell death and nuclear export of C9ORF72 in
Externí odkaz:
https://doaj.org/article/26d01605fb7344faaa67f88fe2c80e8f
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.