Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rima Al-awar"'
Autor:
Andrew J. Best, Ulrich Braunschweig, Mingkun Wu, Shaghayegh Farhangmehr, Adrian Pasculescu, Justin J. Lim, Lim Caden Comsa, Mark Jen, Jenny Wang, Alessandro Datti, Jeffrey L. Wrana, Sabine P. Cordes, Rima Al-awar, Hong Han, Benjamin J. Blencowe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Disruption of alternative splicing frequently causes or contributes to human diseases and disorders. Consequently, there is a need for efficient and sensitive reporter assays capable of screening chemical libraries for compounds with efficac
Externí odkaz:
https://doaj.org/article/bdd3329af36c492bb7c45d82dc1c1b13
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate th
Externí odkaz:
https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1528be5dba214e53abc1707b3bc5de39
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
James J. Dowling, Richard Marcellus, Nathaniel D. Anderson, Rosemarie Venier, Anant Maheshwari, Rebecca A. Gladdy, Sheena Guram, Ludmil B. Alexandrov, Mehdi Layeghifard, Marcus Q. Bernardini, Adam Shlien, Nicholas Light, Jay S. Wunder, Rima Al-awar, Irene L. Andrulis, Matthew Zatzman, Kyoko E. Yuki, Brendan C. Dickson, Peter C. Ferguson, Daniel Durocher, Stefan C. Dentro, Carol J. Swallow, Fabio Fuligni, Yael Babichev, Albiruni Ryan Abdul Razak, Moritz Gerstung, Federico Comitani, Marjan Rouzbahman, Huayun Hou, Claire Wunker, J. Drew Thompson
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not informed by molecular subtyping and is associated with highly variable survival. While disease site continues to dic
Autor:
Hideto Fukushi, Masayuki Takizawa, Shawna Organ, Masoud Vedadi, Peter Brown, Rima Al-awar, Carlo C. dela Seña, Mike Tyers, Carlos Zepeda, Levon Halabelian, David Dilworth, Suzanne Ackloo, Ahmed Aman, Amber L. Couzens, Yoshinori Ishikawa, David Macleod, Nozomu Sakai, Rachel Harding, Stéphane Richard, Tsukasa Sugo, Anne-Claude Gingras, Hiroshi Nara, Fengling Li, Eric Bonneil, Mohammad S. Eram, Cheryl H. Arrowsmith, Shinji Takagi, Dalia Barsyte-Lovejoy, María Sánchez-Osuna, Kozo Hayashi, Magdalena M. Szewczyk
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7
Autor:
Levon Halabelian, Nozomu Sakai, David McLeod, Anne-Claude Gingras, Rima Al-awar, Hiroshi Nara, Dalia Barsyte-Lovejoy, Masoud Vedadi, David Dilworth, Hideto Fukushi, Stéphane Richard, Carlos Zepeda, Cheryl H. Arrowsmith, María Sánchez-Osuna, Ahmed Aman, Carlo C. dela Seña, Kozo Hayashi, Suzanne Ackloo, Magdalena M. Szewczyk, Yoshinori Ishikawa, Peter Brown, Fengling Li, Eric Bonneil, Mike Tyers, Mohammad S. Eram, Masayuki Takizawa, Amber L. Couzens, Shawna Organ, Rachel Harding, Shinji Takagi, Tsukasa Sugo
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7
Autor:
Michael Prakesch, Rima Al-awar, Kenneth Lee, Lynn Lehmann, Gennadiy Poda, Danka Vuga, David Chiovitti, Colleen Schweitzer, Marella D. Canny, Julie L. Lucas, John B. Patterson, Nero Thevakumaran, Andras Toro, Nicole M. Duffy, Qingping Zeng, Igor Kurinov, Daniel Durocher, David Uehling, Victor Tam, Brian J. Wilson, Manisha Talukdar, Mario Sanches, Frank Sicheri
Publikováno v:
Nature communications
Endoplasmic reticulum (ER) stress activates the unfolded protein response and its dysfunction is linked to multiple diseases. The stress transducer IRE1α is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to re-establish
Autor:
Dalia Barsyte-Lovejoy, Peter Brown, Richard Marcellus, Wolfram Tempel, John E. Dick, Masoud Vedadi, Roxana E. Iacob, Alexander J. Federation, Carly Griffin, Jun Qi, Emma J. Chory, Rima Al-awar, Amy K. Wernimont, John R. Engen, Ahmed Aman, Alex Scopton, Matthieu Schapira, Fengling Li, Jason J. Marineau, Guillermina Estiu, James E. Bradner, Taraneh Hajian, Tatiana Shatseva, Wenyu Yu, Joanna Yi, Cheryl H. Arrowsmith, Javier Pineda, Erno Wienholds
Publikováno v:
Nature Communications. 4
Nature Communications 3: Article number: 1288 (2012); Published: 18 December 2012; Updated: 21 May 2013. While this Article was undergoing peer review, Basavapathruni et al. published co-crystal structures of EPZ004777 and related compounds in comple
Autor:
Emma J. Chory, Jun Qi, Joanna Yi, John R. Engen, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Guillermina Estiu, Matthieu Schapira, Wolfram Tempel, John E. Dick, Carly Griffin, Erno Wienholds, Taraneh Hajian, Rima Al-awar, Tatiana Shatseva, James E. Bradner, Wenyu Yu, Jason J. Marineau, Richard Marcellus, Alex Scopton, Amy K. Wernimont, Fengling Li, Javier Pineda, Ahmed Aman, Peter Brown, Roxana E. Iacob, Alexander J. Federation
Publikováno v:
Nature communications. 3
Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development of compounds that selectively inhibit binding of the cofactor, S-adenosylmethionine, within