Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dawang Zhou"'
Autor:
Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou, Yufeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
METTL3 catalyzes mRNA m6A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which
Externí odkaz:
https://doaj.org/article/6d9c4809d19a4cadb353a7ca7474fad8
Autor:
Shuaifeng Li, Shixun Han, Qi Zhang, Yibing Zhu, Haitao Zhang, Junli Wang, Yang Zhao, Jianhui Zhao, Lin Su, Li Li, Dawang Zhou, Cunqi Ye, Xin-Hua Feng, Tingbo Liang, Bin Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Fragmented mitochondria are a frequent hallmark of cancer, but the cause and consequence are less clear. The authors demonstrate that elevated FUNDC2 causes mitochondrial fragmentation through inhibition of MFN1 in hepatocellular carcinoma and that k
Externí odkaz:
https://doaj.org/article/5ec2dd2560f7427f9e3b510ca7292cea
Autor:
Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Innate immune cells respond to a number of environmental cues including TLR signalling. Here the authors implicate mechanical sensor Piezo1 in the TLR4 mediated host response to bacterial infection and implicate it in the enhancement of macrophage me
Externí odkaz:
https://doaj.org/article/75c48bfb0aaf48df8cd5e8d33bcbb665
Autor:
Qiyao Chai, Xudong Wang, Lihua Qiang, Yong Zhang, Pupu Ge, Zhe Lu, Yanzhao Zhong, Bingxi Li, Jing Wang, Lingqiang Zhang, Dawang Zhou, Wei Li, Wenzhu Dong, Yu Pang, George Fu Gao, Cui Hua Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Ubiquitin (Ub)-mediated xenophagy is important in defense against Mycobacterium tuberculosis (Mtb). Here, Chai et al. describe autophagy triggering by Ub binding to the Mtb surface protein Rv1468c, and show that its deletion leads to increased bacter
Externí odkaz:
https://doaj.org/article/74d2a3ea423348b2880c9a031a9391b8
Autor:
Ping Wang, Jing Geng, Jiahui Gao, Hao Zhao, Junhong Li, Yiran Shi, Bingying Yang, Chen Xiao, Yueyue Linghu, Xiufeng Sun, Xin Chen, Lixin Hong, Funiu Qin, Xun Li, Jau-Song Yu, Han You, Zengqiang Yuan, Dawang Zhou, Randy L. Johnson, Lanfen Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and
Externí odkaz:
https://doaj.org/article/c991940c4c9e4e0eb76270e8ea3e81c9
Autor:
Mingdong Liu, Taoling Zeng, Xin Zhang, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao, Hong-Rui Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibitio
Externí odkaz:
https://doaj.org/article/fb0cf4ef163142abb62caefcf0ec80c7
Autor:
Jinjia Zhang, Yiran Shi, Jing Geng, Weihong Yuan, Ping Wang, Hao Zhao, Dawang Zhou, Bingying Yang, Xianming Deng, Funiu Qin, Lixin Hong, Yujie Sun, Junhong Li, Lanfen Chen, Congying Wu, Changchuan Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR
Autor:
Jing Wang, Qiyao Chai, Yanzhao Zhong, Lingqiang Zhang, Yong Zhang, Wenzhu Dong, Cui Hua Liu, George F. Gao, Pupu Ge, Yu Pang, Dawang Zhou, Wei Li, Xudong Wang, Bingxi Li, Zhe Lu, Lihua Qiang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Ubiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens including Mycobacterium tuberculosis (Mtb). However, the exact mechanism by which host ubiquitin targets invaded microbes
Autor:
Dawang Zhou, Hong-Rui Wang, Mingdong Liu, Hui Xia, Taoling Zeng, Hong-Lin Chan, Liping Xie, Changchuan Xie, Chunyan Liu, Xin Zhang, Xianming Deng, Tong Jin Zhao, Luming Yao, Zhihui Wu, Qi Lin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that DNA damage leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition. DNA da
Autor:
Lanfen Chen, Han You, Zengqiang Yuan, Jing Geng, Yiran Shi, Yueyue Linghu, Jau-Song Yu, Ping Wang, Jiahui Gao, Xun Li, Dawang Zhou, Randy L. Johnson, Chen Xiao, Hao Zhao, Bingying Yang, Junhong Li, Xiufeng Sun, Funiu Qin, Xin Chen, Lixin Hong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective mechanism against such potential damage from oxidative stress remains unclear. Here we show that the kinases