Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cheng Fan"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Effective precision medicine strategies rely on the ability to predict tumour behaviour based on molecular characteristics. Here, the authors build models to predict multiple distinct gene expression patterns using DNA copy number alterations
Externí odkaz:
https://doaj.org/article/aacfa53818d64b05907242403be4e602
Autor:
Giada Zurlo, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M. Simon, Travis S. Ptacek, Javier Rodriguez, Alex von Kriegsheim, Juan Liu, Jason W. Locasale, Adam Robinson, Jing Zhang, Jessica M. Holler, Baek Kim, Marie Zikánová, Jörgen Bierau, Ling Xie, Xian Chen, Mingjie Li, Charles M. Perou, Qing Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The hydroxylase EgIN2 contributes to triple negative breast cancers. Here, using an enzyme-substrate trapping strategy, the authors identify ASDL as a bona fide substrate of EgIN2 promoting aggressive properties of TNBC via the activation of cMYC sig
Externí odkaz:
https://doaj.org/article/4f3b6b5738bf4496a2ce34dde8289124
Autor:
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic ac
Externí odkaz:
https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
Akademický článek
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Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
The ability to characterize and predict tumor phenotypes is crucial to precision medicine. In this study, we present an integrative computational approach using a genome-wide association analysis and an Elastic Net prediction method to analyze the re
Autor:
Xijuan Liu, Adam Robinson, Alex von Kriegsheim, Ling Xie, Baek Kim, Travis S. Ptacek, Mingjie Li, Cheng Fan, Jeremy M. Simon, Xian Chen, Jörgen Bierau, Juan Liu, Charles M. Perou, Marie Zikanova, Javier Rodriguez, Jing Zhang, Jason W. Locasale, Jessica Holler, Qing Zhang, Giada Zurlo, Mamoru Takada
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10:5177. Nature Publishing Group
Zurlo, G, Liu, X, Takada, M, Fan, C, Simon, J M, Ptacek, T S, Rodriguez Martinez, J, Von Kriegsheim, A, Liu, J, Locasale, J W, Robinson, A, Zhang, J, Holler, J M, Baek, K, Zikanova, M, Jorgen, B, Ling, X, Chen, X, Lie, M, Perou, C M & Zhang, Q 2019, ' Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer ', Nature Communications . https://doi.org/10.1038/s41467-019-13168-4
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10:5177. Nature Publishing Group
Zurlo, G, Liu, X, Takada, M, Fan, C, Simon, J M, Ptacek, T S, Rodriguez Martinez, J, Von Kriegsheim, A, Liu, J, Locasale, J W, Robinson, A, Zhang, J, Holler, J M, Baek, K, Zikanova, M, Jorgen, B, Ling, X, Chen, X, Lie, M, Perou, C M & Zhang, Q 2019, ' Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer ', Nature Communications . https://doi.org/10.1038/s41467-019-13168-4
Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By d
Akademický článek
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Autor:
Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small mo
Externí odkaz:
https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50