Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Balázs Győrffy"'
Autor:
Ferhat Alkan, Anna G. Manjón, Balázs Győrffy, William J. Faller, Selçuk Yavuz, Ben Morris, Bram van den Broek, Stefan Prekovic, Mark Buijs, Liesbeth Hoekman, Joana Silva, Karin E. de Visser, Hans Teunissen, Tesa M. Severson, Theofilos Chalkiadakis, Wilbert Zwart, Donna O. Debets, Max D. Wellenstein, Anne Huber, René H. Medema, Alejandro Barrera, Elzo de Wit, Isabel Mayayo-Peralta, Karianne Schuurman, Timothy E. Reddy, Cor Lieftink, Maarten Altelaar, Roderick L. Beijersbergen, Jos Jonkers, Kim Monkhorst
Publikováno v:
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):4360. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):4360. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The glucocorticoid receptor (GR) regulates gene expression, governing aspects of homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently used to alleviate therapy-related side-effects. While prior studies have shown G
Autor:
Charlotte Ion, Alba Rodriguez-Meira, Armando del Río Hernández, Naina Patel, Pasquale Marrazzo, Adrian Lim, Aaron J. Farrugia, Jennifer H. Steel, Antonios Chronopoulos, Monica Faronato, Charles Coombes, Luca Magnani, Balázs Győrffy, Claire Davies, Andrea Uggetti, Sami Shousha, Giancarlo Pruneri, Fernando Calvo, Ylenia Perone
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate
Autor:
Simak Ali, Saverio Minucci, Ylenia Lombardo, R. Charles Coombes, Luca Magnani, Philippa D. Darbre, Naina Patel, Gianmaria Frigè, Laura Woodley, Van T. M. Nguyen, Valentina Vircillo, Manikandan Periyasamy, Leandro Castellano, Alba Rodriguez-Meira, Balázs Győrffy, Jennifer H. Steel, Monica Faronato, Darren K. Patten, Iros Barozzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature Communications
Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we demonstrate that resistance emerg
Autor:
Herwig P. Moll, Helmut Popper, Gerda Egger, Emilio Casanova, Thomas Mohr, Richard Moriggl, Thomas Hoffmann, Valeria Poli, Harald Esterbauer, Patricia Stiedl, Johannes Zuber, Robert Eferl, Leander Blaas, Edith Bogner, Katalin Zboray, Eva Bauer, Dagmar Stoiber, Josef M. Penninger, Wolfgang Gruber, Jasmin Svinka, Lukas Kenner, Beatrice Grabner, Harini Nivarthi, Ralf Harun Zwick, Daniel Schramek, Kristina M. Mueller, Balázs Győrffy, Natascha Hruschka, Fritz Aberger
Publikováno v:
Nature communications. 6
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppressive role i
Autor:
Balázs Győrffy, Thomas Eder, Giulio Superti-Furga, Peter Valent, Alexey Stukalov, Matthias Muhar, Martin Aichinger, Anna Skucha, Keiryn L. Bennett, Christopher R. Vakoc, Sarah Vittori, André C. Müller, Johannes Zuber, Julian Jude, Mareike Roth, Johannes Schmöllerl, Florian Grebien, Bin Lu, Jessica Ebner, Adrián César-Razquin
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying