Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Aleksey V. Matveyenko"'
Autor:
Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression
Externí odkaz:
https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
Autor:
Quan Zhou, Maria Sörhede-Winzell, Douglas A. Melton, Shaimaa Hassoun, Jennifer H. R. Kenty, Aleksey V. Matveyenko, Matthew R. Brown, Caden D. Duffy, Adrian Veres, Björn Tyrberg, Patrik Rorsman, Michael Q. Slama, Lihua Chen, Quinn P. Peterson, Haiqiang Dou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused on generating pancreatic beta cells, considerable evidence indicates that glucagon secreti
Autor:
Brianne S Thicke, Ming Ruan, Aleksey V. Matveyenko, Jennifer R. Geske, Merry Jo Oursler, Amanda J Tweed, David G. Monroe, Bart L. Clarke, Brittany A. Eckhardt, Thomas Levin Andersen, Joshua N. Farr, Chee Kian Chew, Matthew T. Drake, Sundeep Khosla, Adrian Vella, Robert A. Rizza, Elizabeth J. Atkinson, Moustapha Kassem, Louise K. McCready, Megan M. Weivoda
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsie