Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Yu An"'
Autor:
Yu-Long Wang, Jia-Qian Hu, Qinghai Ji, Yu Wang, Xiaohua Hu, Xiaoming Zhang, Zhongwu Lu, Wen-Jun Wei, Ning Qu, Huajun Li, Hualei Gan, Li-Cheng Tan, Peng-Cheng Yu, Weilin Pu, Zaili Luo, Zhiyan Liu, Jiucun Wang, Dongmei Ji, Xiao Shi, Meiying Zhang, Pei-Zhen Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients’ paratumors, localized/advanced tumors, initially-treated/recurrent lymp
Autor:
Liqin Xu, Jia Fan, Yu Zhong, Miaomiao Jiang, Xiao-Rui Zhou, Yong Hou, Geng Liu, Min Du, Guibo Li, Shuang-Jian Qiu, Yuan Ji, Sun Yunfan, Xiangdong Wang, Bo Hu, Ashley R. Dennison, Sheng Liu, Ze-Fan Zhang, Qichao Yu, Xiaoyun Huang, Yang Xu, Ying-Hong Shi, David H. Peng, Wen-Yuan Chung, Kai-Qian Zhou, Nannan Li, Wei Guo, Liang Wu, Jian Zhou, Xin-Rong Yang, Hui-Chuan Sun, Michael Dean, Shiping Liu, Zhikun Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepa
Autor:
Xiang Yu Zhuang, Fan Bai, Yi Jen Sun, Yu Cheng Sung, Tsai Shun Lin, An Chi Luo, Chien-Jung Lo, Yu-Ling Shih
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
The dynamic assembly of the cell wall is key to the maintenance of cell shape during bacterial growth. Here, we present a method for the analysis of Escherichia coli cell wall growth at high spatial and temporal resolution, which is achieved by traci
Autor:
Chi Liu, Chia-Chi Fan, Shu-Yung Lin, Xuan-Hui Lin, Rueyhung R Weng, Hsuan-Hsuan Lu, Yi-Chieh Wu, Tai-Chung Huang, Shih-Yu Chen, Tzu-Yuan Chiu, Yi-Hsiu Juan, Rong-Shan Lin, Hsing-Chen Tsai, Jung-Chi Liao, Chong-Jen Yu, Zheng-Ci Hung, Wan-Chen Hsieh, Yi-Jhen Huang, Yen-Ling Chiu, Chien-Ting Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we sh
Autor:
Dan Luo, Yu Wang, Yan Liu, Lisha Zhu, Bo Guan, Cun-Yu Wang, Danqing He, Shanshan Jin, Ting Zhang, Yanheng Zhou, Chunyan Shi, Zixin Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Tendon injuries disrupt the balance between stability and mobility, causing compromised functions and disabilities. The regeneration of mature, functional tendons remains a clinical challenge. Here, we perform transcriptional profiling of tendon deve
Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
Autor:
Rui Wu, Hang Shi, Jia Jing, Yi Pan, Huidong Shi, Ziyue Chen, Qiang Cao, Liqing Yu, Bingzhong Xue, Fenfen Li, Miranda Movahed, Xin Cui
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat
Autor:
Mu Sheng Zeng, Qian-Ying Zhu, Lan-Yi Zhong, Si-Ying Peng, Su-Mei Cao, Sisi Shan, Jinfang Yu, Xinquan Wang, Cong Sun, Yong-Jian Peng, Linqi Zhang, Ziqing Yang, Xuanling Shi, Yanan Zuo, Xiao Zhang, Shu-Mei Yan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Epstein-Barr virus (EBV) is associated with a range of epithelial and B cell malignancies as well as autoimmune disorders, for which there are still no specific treatments or effective vaccines. Here, we isolate EBV gH/gL-specific antibodies from an
Autor:
Jordan Benderoth, Lara Jabbour, Ukpong B. Eyo, Marie-Ève Tremblay, Yu-Yo Sun, Kanchan Bisht, Joseph O. Uweru, Bruce A. Corliss, Kaushik Sharma, Antony Brayan Campos-Salazar, Brant E. Isakson, Hong-Ru Chen, Saipranusha Amancherla, Kenneth A. Okojie, Zainab Calcuttawala, Dennis H. Lentferink, Chia-Yi Kuan, Bria Friestad, William A. Mills
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, the extent of their interactions with the vasculature and potential regulation of vascular physiology has been insufficiently explored. Here, we document
Autor:
Huidong Shi, Gary J. Schwartz, Fenfen Li, Bingzhong Xue, Shirong Wang, Rui Wu, Liqing Yu, Jia Jing, Xin Cui, Qiang Cao, Ke Li, Hang Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis. Here we discover a fat-derived “adipokine” neurotrophic factor neurot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively transferred tumor-reactive T cells. As anti-CD4 monoclonal antibody depletes CD4+ immune-su