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Autor:
Shaw, Sebastian, Knüsel, Sebastian, Abbühl, Daniel, Naguleswaran, Arunasalam, Etzensperger, Ruth, Benninger, Mattias, Roditi, Isabel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nature Communications
Nature Communications
The collective movement of African trypanosomes on semi-solid surfaces, known as social motility, is presumed to be due to migration factors and repellents released by the parasites. Here we show that procyclic (insect midgut) forms acidify their env
Autor:
David T. Breault, Wanshu Qi, Jose Ordovas-Montanes, Sarah Dubois, Diana L. Carlone, Manasvi S. Shah, Daniel Zeve, Joshua de Sousa Casal, Sophie Hafner, Eric Stas, Jeffrey M. Karp, Xiaolei Yin, Erin Syverson, Prabhath Mannam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Nature Communications
Nature Communications
Enteroendocrine (EE) cells are the most abundant hormone-producing cells in humans and are critical regulators of energy homeostasis and gastrointestinal function. Challenges in converting human intestinal stem cells (ISCs) into functional EE cells,
Autor:
Kevin Huynh, Tegan Stait, Cesare Granata, Melinda T. Coughlan, David Bishop, Natalie A. Mellett, H. Janssen, Jujiao Kuang, Nikeisha J Caruana, Nicholas A. Jamnick, Peter J. Meikle, David A. Stroud, Boris Reljic, Adrienne Laskowski, David R. Thorburn, Javier Botella, Ann E. Frazier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an accessible, inexpensive therapeutic intervention that can improve mitochondrial bioenergetics and quality of life. By combining multiple omics techniques wit
Autor:
Ostgaard Cm, Hamm Dc, Choul-Gyun Lee, Schnell Jm, Tyler J. Gibson, Elizabeth D. Larson, Hideyuki Komori, Melissa M. Harrison
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
During Drosophila embryogenesis, the essential pioneer factor Zelda defines hundreds of cis-regulatory regions and in doing so reprograms the zygotic transcriptome. While Zelda is essential later in development, it is unclear how the ability of Zelda
Autor:
Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;
Autor:
Bernice Leung, Thomas Dodd, Chunli Yan, Jun Xu, Ivaylo Ivanov, Dong Wang, Juntaek Oh, Jina Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Transcription-coupled repair is essential for the removal of DNA lesions from the transcribed genome. The pathway is initiated by CSB protein binding to stalled RNA polymerase II. Mutations impairing CSB function cause severe genetic disease. Yet, th
Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
Autor:
Rui Wu, Hang Shi, Jia Jing, Yi Pan, Huidong Shi, Ziyue Chen, Qiang Cao, Liqing Yu, Bingzhong Xue, Fenfen Li, Miranda Movahed, Xin Cui
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat
Autor:
Jia-Xin Jiang, Sunny Xia, Markus Grompe, Christine E. Bear, Changyi Cui, Hiroshi Suemizu, Yuichiro Higuchi, Avrilynn Ding, Mina Ogawa, Onofrio Laselva, Shinichiro Ogawa, Craig Dorrell, Donghe Yang, Marcela Hernandez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
The derivation of mature functional cholangiocytes from human pluripotent stem cells (hPSCs) provides a model for studying the pathogenesis of cholangiopathies and for developing therapies to treat them. Current differentiation protocols are not effi
Autor:
Andrew Hudson, Yen Peng Chew, Attila Molnar, Charlotte von Koppenfels, Erika Kroll, Aron Ferenczi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Ferenczi, A, Chew, Y P, Kroll, E, von Koppenfels, C, Hudson, A D & Molnar, A 2021, ' Mechanistic and genetic basis of single-strand templated repair at Cas12a-induced DNA breaks in Chlamydomonas reinhardtii ', Nature Communications, no. 12, 6751 . https://doi.org/10.1038/s41467-021-27004-1
Nature Communications
Ferenczi, A, Chew, Y P, Kroll, E, von Koppenfels, C, Hudson, A D & Molnar, A 2021, ' Mechanistic and genetic basis of single-strand templated repair at Cas12a-induced DNA breaks in Chlamydomonas reinhardtii ', Nature Communications, no. 12, 6751 . https://doi.org/10.1038/s41467-021-27004-1
Nature Communications
Single-stranded oligodeoxynucleotides (ssODNs) are widely used as DNA repair templates in CRISPR/Cas precision genome editing. However, the underlying mechanisms of single-strand templated DNA repair (SSTR) are inadequately understood, constraining r