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Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
Autor:
Rui Wu, Hang Shi, Jia Jing, Yi Pan, Huidong Shi, Ziyue Chen, Qiang Cao, Liqing Yu, Bingzhong Xue, Fenfen Li, Miranda Movahed, Xin Cui
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Transcription modulated by the circadian clock is diverse across cell types, underlying circadian control of peripheral metabolism and its observed perturbation in human diseases. We report that knockout of the lineage-specifying Hnf4a gene in mouse
Autor:
Hai-Kun Liu, Michael P. Moore, Tassia Mangetti Gonçalves, Naveen C. Reddy, James A. J. Fitzpatrick, Azad Bonni, Cole J. Ferguson, Mati Nemera, Harrison W. Gabel, Shahriyar P. Majidi, Lingchun Kong, Tomoko Yamada, Guoyan Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Regulation of chromatin plays fundamental roles in the development of the brain. Haploinsufficiency of the chromatin remodeling enzyme CHD7 causes CHARGE syndrome, a genetic disorder that affects the development of the cerebellum. However, how CHD7 c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), including phosphorylation and ubiquitination, control NLRP3 protein degradation and inflammasome activa
Autor:
Kanaka Durga Devi Gorrepati, Amin Ardestani, Aleksandra Dobrowolski, Kathrin Maedler, Zahra Azizi, Jaee Ghawali, Ting Yuan, Dae-Sik Lim, Blaz Lupse, Shirin Geravandi, Marina Ruhlandt, Shruti Naik, Karthika Annamalai, Anasua Pal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo sig
Autor:
Rachit Badolia, Salah Sommakia, Aishwarya Aravamudhan, Aspasia Thodou Krokidi, Dipayan Chaudhuri, Thomas Gudermann, Paulina Sander, Kira Steinhorst, Ohyun Kwon, Stavros G. Drakos, Dinesh K. A. Ramadurai, Kenneth W. Spitzer, Sutip Navankasattusas, Andreas Dendorfer, Frank B. Sachse, Jing Ling, Emily H. Cheng, Thirupura S. Shankar, Johann Schredelseker, Dallen Calder, Kevin J. Whitehead, Changmin Xie, Oh Sung Kwon, Russel S. Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can
Autor:
Jun Xu, Jun-Ying Wang, Fang Luo, Min-Min Lou, Huan Zou, Yi Wu, Guangming Wang, Jia He, Guo-Ming Ma, Aibin Liang, Qun Zhang, Liu-Lin Xiong, Fei Wang, Qi-Li Shi, Ming-Jian Xu, Xiao-Qiang Tang, Yaoyang Zhang, Ting-Hua Wang, Jian Wang, Li-Bing Shen, Wenyuan Wang, Mingfeng Guan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we
Autor:
Joseph W. Dean, Lifeng Xiong, Timothy J. Garrett, Zongming E. Chen, Christian Jobin, Zheng Fu, Liang Zhou, Kristen N. Oliff, Michael Dougherty
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
RORγt+ lymphocytes, including interleukin 17 (IL-17)-producing gamma delta T (γδT17) cells, T helper 17 (Th17) cells, and group 3 innate lymphoid cells (ILC3s), are important immune regulators. Compared to Th17 cells and ILC3s, γδT17 cell metabo
Autor:
Antonio C. Bianco, Gustavo W. Fernandes, Tzintzuni Garcia, Tatiana L. Fonseca, T. Murlidharan Nair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific
Autor:
Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we sho