Zobrazeno 71 - 80
of 587
pro vyhledávání: ''
Autor:
Laura D. Attardi, Ciaran M. Lee, Kazuki Sawamoto, Rasmus O. Bak, Laure Aurelian, Rolen M. Quadros, Samantha G. Scharenberg, Matthew H. Porteus, Natalia Gomez-Ospina, Carlos Suárez, Sruthi Mantri, Shaukat Khan, Nitin Raj, Nathalie Mostrel, Shunji Tomatsu, Gang Bao, Channabasavaiah B. Gurumurthy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Gomez-Ospina, N, Scharenberg, S G, Mostrel, N, Bak, R O, Mantri, S, Quadros, R M, Gurumurthy, C B, Lee, C, Bao, G, Suarez, C J, Khan, S, Sawamoto, K, Tomatsu, S, Raj, N, Attardi, L D, Aurelian, L & Porteus, M H 2019, ' Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I ', Nature Communications, vol. 10, no. 1, 4045, pp. 4045 . https://doi.org/10.1038/s41467-019-11962-8
Nature Communications
Gomez-Ospina, N, Scharenberg, S G, Mostrel, N, Bak, R O, Mantri, S, Quadros, R M, Gurumurthy, C B, Lee, C, Bao, G, Suarez, C J, Khan, S, Sawamoto, K, Tomatsu, S, Raj, N, Attardi, L D, Aurelian, L & Porteus, M H 2019, ' Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I ', Nature Communications, vol. 10, no. 1, 4045, pp. 4045 . https://doi.org/10.1038/s41467-019-11962-8
Lysosomal enzyme deficiencies comprise a large group of genetic disorders that generally lack effective treatments. A potential treatment approach is to engineer the patient’s own hematopoietic system to express high levels of the deficient enzyme,
Autor:
Mingdong Liu, Huan Shi, Tengchuan Jin, Xiaobo Liu, Huihui Zhang, Yongning He, Xueying Yin, Yingjie Zhao, Yan Zhang, Fubin Li, Boxun Lu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc impact on their agonistic functions have been disputed.
Autor:
Deshun Gong, Fudong Li, Yongrui Liu, Yunyu Shi, Yanxin Xu, Xudong Guo, Xuwen Chen, Wen Chen, Jiajing Chen, Qingtao Wei, Jiuhong Kang, Zikang Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Recognition of specific chromatin modifications by distinct structural domains within “reader” proteins plays a critical role in the maintenance of genomic stability. However, the specific mechanisms involved in this process remain unclear. Here
Autor:
Michael A. Rudnicki, Caroline E. Brun, Christopher J. Porter, Marie-Claude Sincennes, A. Francis Stewart, John Saber, Patricia Ernst, Gregory C. Addicks
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. We previously found that PAX7 recruits the H3K4 methylt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
PTEN is frequently mutated in prostate cancer. The tumor suppressor function of PTEN is attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN-ARID4B-PI3K axis in which PTEN inhibits expression of ARID4B, while
Autor:
Donghai Wang, Malin C. Erlandsson, Mohamed X. Ibrahim, Israiel T. Kumar, Christin Karlsson, Cord Brakebusch, Xiufeng Xu, Volkan I. Sayin, Maria Bokarewa, Omar M. Khan, Emil G. Ivarsson, Martin O. Bergo, Murali K. Akula, Mikael Brisslert
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Akula, M K, Ibrahim, M X, Ivarsson, E G, Khan, O M, Kumar, I T, Erlandsson, M, Karlsson, C, Xu, X, Brisslert, M, Brakebusch, C, Wang, D, Bokarewa, M, Sayin, V I & Bergo, M O 2019, ' Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions ', Nature Communications, vol. 10, no. 1, 3975, pp. 1-13 . https://doi.org/10.1038/s41467-019-11606-x
Nature Communications
Akula, M K, Ibrahim, M X, Ivarsson, E G, Khan, O M, Kumar, I T, Erlandsson, M, Karlsson, C, Xu, X, Brisslert, M, Brakebusch, C, Wang, D, Bokarewa, M, Sayin, V I & Bergo, M O 2019, ' Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions ', Nature Communications, vol. 10, no. 1, 3975, pp. 1-13 . https://doi.org/10.1038/s41467-019-11606-x
Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, lead
Autor:
Jin, Meihua, Shiwaku, Hiroki, Tanaka, Hikari, Obita, Takayuki, Ohuchi, Sakurako, Yoshioka, Yuki, Jin, Xiaocen, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Nakajima, Kazuyuki, Mizuguchi, Mineyuki, Okazawa, Hitoshi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Brain inflammation generally accompanies and accelerates neurodegeneration. Here we report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses extrinsic tau 3R/4R proteins by direct interaction and triggers an innate immune
Autor:
Collene R. Jeter, Jianji Chen, Fen Yang, Mark T. Bedford, Guozhen Gao, Manu M. Sebastian, Jianjun Shen, Maria D. Person, Bin Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
SPINDOC is tightly associated with the histone H3K4me3 effector protein SPIN1. To gain a better understanding of the biological roles of SPINDOC, we identified its interacting proteins. Unexpectedly, SPINDOC forms two mutually exclusive protein compl
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The mammalian SWI/SNF nucleosome remodeler is essential for spermatogenesis. Here, we identify a role for ARID2, a PBAF (Polybromo - Brg1 Associated Factor)-specific subunit, in meiotic division. Arid2cKO spermatocytes arrest at metaphase-I and are d
Autor:
Gen Lin, Irina Grishkovskaya, Rushad Pavri, Alexander Stark, Anna Vlasova, Richard Štefl, Ursula E. Schoeberl, Melania Bruno, Carrie Bernecky, Lisa-Marie Appel, Vedran Franke, Martin Leeb, Aiste Kasiliauskaite, Carmen Ebenwaldner, Sebastian Kostrhon, Etienne Beltzung, Kristina Djinović-Carugo, Altuna Akalin, Tanja Kaufmann, Dea Slade, Marek Sebesta, Martin Puchinger, Karl Mechtler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks ont