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Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Cilia are microtubule-based hair-like organelles propelling locomotion and extracellular liquid flow or sensing environmental stimuli. As cilia are diffusion barrier-gated subcellular compartments, their protein components are thought to come from th
Autor:
Cheng Li, Ling Zhang, Lang Chen, Hongru Pan, Jiayu Chen, Zhen Sun, Yuyan Xu, Ming Chen, Pengxu Qian, Yuqing Zhu, George Q. Daley, Tianyu Tan, Zhengping Xu, Jinghao Sheng, Shaorong Gao, Jin Zhang, Anhua Lei, Hua Yu, Jing Zhao, Yaxin Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications
Nature Communications
The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can dri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), including phosphorylation and ubiquitination, control NLRP3 protein degradation and inflammasome activa
Autor:
Kanaka Durga Devi Gorrepati, Amin Ardestani, Aleksandra Dobrowolski, Kathrin Maedler, Zahra Azizi, Jaee Ghawali, Ting Yuan, Dae-Sik Lim, Blaz Lupse, Shirin Geravandi, Marina Ruhlandt, Shruti Naik, Karthika Annamalai, Anasua Pal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo sig
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
We hypothesized that the highly controlled pattern of gene expression that is essential for liver regeneration is encoded by an epigenetic code set in quiescent hepatocytes. Here we report that epigenetic and transcriptomic profiling of quiescent and
Autor:
Joseph W. Dean, Lifeng Xiong, Timothy J. Garrett, Zongming E. Chen, Christian Jobin, Zheng Fu, Liang Zhou, Kristen N. Oliff, Michael Dougherty
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
RORγt+ lymphocytes, including interleukin 17 (IL-17)-producing gamma delta T (γδT17) cells, T helper 17 (Th17) cells, and group 3 innate lymphoid cells (ILC3s), are important immune regulators. Compared to Th17 cells and ILC3s, γδT17 cell metabo
Autor:
Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we sho
Autor:
Perry E. Bickel, Chaofeng Yang, Joshua A. Johnson, Violeta I. Gallardo-Montejano, John L. McAfee, William L. Holland, Lisa Hahner, Rodrigo Fernandez-Valdivia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Exposure of mice or humans to cold promotes significant changes in brown adipose tissue (BAT) with respect to histology, lipid content, gene expression, and mitochondrial mass and function. Herein we report that the lipid droplet coat protein Perilip
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Olfactory sensory neurons express a large family of odorant receptors (ORs) and a small family of trace amine-associated receptors (TAARs). While both families are subject to so-called singular expression (expression of one allele of one gene), the m