Zobrazeno 11 - 20
of 670
pro vyhledávání: ''
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Autor:
Wenwei Hu, John J. Ponessa, Lanjing Zhang, Yuhan Zhao, Juan Liu, Zhaohui Feng, Chun Yuan Chang, Mark C. Siracusa, Jianming Wang, Fan Zhou, Huaying Wang, Xue Yang, Juan M. Inclan-Rico, Xuetian Yue, Ping Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity
Autor:
James Dight, Sam L. Kahler, Edwige Roy, Ho Yi Wong, Jatin Patel, Hamish Hamilton, Racheal Wadlow, Mathias Francois, Isabella Hogan, Seen Ling Sim, Simranpreet Kaur, Laura Sormani, Kiarash Khosrotehrani, Mervin C. Yoder, Jilai Zhao, Ghazaleh Hashemi, Cassandra Styke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease, however its mechanism has yet to be elucidated. The endothelium possesses a profound regenerative capacity to adapt and reorganize that is attributed to a popul
Autor:
Janos Peti-Peterdi, Haibin Xi, Yung-Chih Lai, Ya Chen Liang, Sheng Pei Wang, Ben Van Handel, Stephanie Tsai, Ting-Xin Jiang, Thomas E. Woolley, Cheng-Ming Chuong, Hans I.Chen Harn, Michael W. Hughes, Denis Evseenko, Arijita Sarkar, Stefan Kaemmer, Ina Maria Schiessl, Ming Jer Tang, April D. Pyle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Tissue regeneration is a process that recapitulates and restores organ structure and function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice (Mus), the regeneration is limited to the center of the
Autor:
Yunfei Wang, Jiafu Long, Xin Zhou, Chenxi He, Hao Zhou, Jian Hu, Shaobo Wang, Fei Lan, Qiang Zhang, Yanjun Wei, Takashi Shingu, Qinling Mo, Ailiang Zeng, Hongtao Li, Seula Shin, Yiwen Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains unclear. Here, we show that Quaking (Qki) is required for the transcr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types, since their mRNA contents are diluted in th
Autor:
Keishi Miyata, Koichi Node, Aman Makaju, Kimi Araki, Yoshihiro Komohara, Anna Bakhtina, Taichi Sugizaki, Kumiko Yoshinobu, Zhe Tian, Kaname Hirashima, Shunshun Zhu, Sarah Franklin, Junco S. Warren, Tomohiko Wakayama, Yuichi Oike, Shinichi Nakagawa, Haruki Horiguchi, Tsuyoshi Kadomatsu, Jun Morinaga, Masatake Araki, Michio Sato, Mai Imasaka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications
Nature Communications
In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in vitro functions defined, although in some cases their functions in vivo remain less clear. Moreover, unlike nuclear lncRNAs, the roles of cytoplasmic lncRNAs are
Autor:
Vijay Saxena, David S. Hains, Hongyu Gao, Malgorzata M. Kamocka, Samuel Arregui, Michael P. Hutchens, Xiaoling Xuei, Takashi Hato, Andrew L. Schwaderer, Patrick C. McGuire, Amy Zollman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Kidney intercalated cells are involved in acid-base homeostasis via vacuolar ATPase expression. Here we report six human intercalated cell subtypes, including hybrid principal-intercalated cells identified from single cell transcriptomics. Phagosome
Autor:
Kyle C. A. Wedgwood, Steffen Scholpp, David M. Virshup, Gediminas Greicius, Benjamin D. Evans, Sally L. Rogers, Lucy H. Brunt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Wnt signaling regulates cell proliferation and cell differentiation as well as migration and polarity during development. However, it is still unclear how the Wnt ligand distribution is precisely controlled to fulfil these functions. Here, we show th
Autor:
Joseph A. Hill, Xuliang Wang, Nan Jiang, Soo Young Kim, Stephen B. Spurgin, Hande Piristine, Sergio Lavandero, Kristin M. French, Vlad G. Zaha, Francisco Altamirano, Subhajit Dasgupta, Anwarul Ferdous, Theodore M. Hill, Herman I. May, Thomas G. Gillette, Maayan Waldman, Dan Tong, Gabriele G. Schiattarella, Heesoo Yoo, Yuxuan Luo, Elisa Villalobos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing me