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Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of u
Autor:
Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩
The liver plays a central role in metabolism, protein synthesis and detoxification. It possesses unique regenerative capacity upon injury. While many factors regulating cellular proliferation during liver repair have been identified, the mechanisms b
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Tissue growth in the adult is an orchestrated process that often requires biological clocks to time stem cell and progenitor activity. Here, we employed the hair follicle, which cycles between growth and regression in a timely-restricted mode, to sho
Autor:
Mary Ziegler, Katrina M. Welch-Reardon, Nathan N. Shon, Jennifer S. Fang, Nan W. Hultgren, Duc T. T. Phan, Antonio E. Paniagua, Ali Mortazavi, Ricardo Ramirez, Christopher C.W. Hughes, Lin S. Kim, Michaela M.S. Hatch, David S. Williams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT). Here, we show that Slug is critical for the pathological angiogenesis neede
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The protein high-mobility group box 1 (HMGB1) is released into the extracellular space in response to many inflammatory stimuli, where it is a potent signaling molecule. Although research has focused on downstream HMGB1 signaling, the means by which
Autor:
Ting Dong, Jianzhu Chen, Yingzhong Li, Nikola A. Ivica, Paula T. Hammond, Walter W. Chen, Amanda M. Del Rosario, Matthew G. Vander Heiden, Dimitrios P. Papageorgiou, Douglas Brown, Yanpu He, Lucas B. Sullivan, Guangan Hu, Marianna Kleyman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
ATP synthesis and thermogenesis are two critical outputs of mitochondrial respiration. How these outputs are regulated to balance the cellular requirement for energy and heat is largely unknown. Here we show that major facilitator superfamily domain
Autor:
Christopher C. Griffith, Martin Zenker, William E. Allen, Ganka Douglas, Denise Howting, Eissa Faqeih, Roger B. Sher, Davut Pehlivan, Nigel G. Laing, Henry Houlden, Jennifer E. Stauffer, Naif A.M. Almontashiri, Hamid Galehdari, Paige B. Martin, Ryo Yonashiro, Rajesh Kumar, Tamar Harel, Yu Kigoshi-Tansho, Gregory A. Cox, James R. Lupski, Reza Maroofian, Monique M. Ryan, Gianina Ravenscroft, Neda Mazaheri, Jennifer E. Posey, Tina Müller, Claudio A. P. Joazeiro, Denny Schanze
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
A hallmark of neurodegeneration is defective protein quality control. The E3 ligase Listerin (LTN1/Ltn1) acts in a specialized protein quality control pathway—Ribosome-associated Quality Control (RQC)—by mediating proteolytic targeting of incompl
Autor:
Marina Pretolani, Yashaswi Shrestha, Jingya Wang, Fatima Hamidi, Roland Kolbeck, Jincheng Wu, Michel Aubier, Valérie Besnard, Alison A. Humbles, Alan M. Copenhaver, Rania Dagher, Aaron A Berlin, Xiaotao Qu, Rajiv Raja, Gregory Gautier, Marielle Maret
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Evidence points to an indispensable function of macrophages in tissue regeneration, yet the underlying molecular mechanisms remain elusive. Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial epithelial repair, and implicate
Autor:
Luca Scorrano, Fred N. Ross-Cisneros, Alfredo A. Sadun, Martina Semenzato, Marta Zaninello, Francesca Grespi, Keiko Iwata, Konstantinos Palikaras, Ruben Quintana-Cabrera, Valerio Carelli, Stéphanie Herkenne, Deborah Naon, Nektarios Tavernarakis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
In autosomal dominant optic atrophy (ADOA), caused by mutations in the mitochondrial cristae biogenesis and fusion protein optic atrophy 1 (Opa1), retinal ganglion cell (RGC) dysfunction and visual loss occur by unknown mechanisms. Here, we show a ro
Autor:
Xiaoming Wang, Thomas A. Ray, Jingjing Wang, Alessandro Iannaccone, Nikolai P. Skiba, Chris Kozlowski, Jeremy N. Kay, William J. Spencer, Annelies Laeremans, Vadim Y. Arshavsky, Martha A. Cady, Olivier Fedrigo, Brian S. Clark, Gary Hu, Kelly Cochran, Ming-Xiao He, Graham Alexander, Philip A. Ruzycki, Emily Park, Ying Hao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Genes encoding cell-surface proteins control nervous system development and are implicated in neurological disorders. These genes produce alternative mRNA isoforms which remain poorly characterized, impeding understanding of how disease-associated mu