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pro vyhledávání: ''
Autor:
Xiaofeng Fu, Daniel K. Clare, Dapeng Sun, Corey W. Hecksel, Mark S. Boyce, Peijun Zhang, Abhay Kotecha, Geoff Sutton, David I. Stuart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
Traditionally, molecular assembly pathways for viruses are inferred from high resolution structures of purified stable intermediates, low resolution images of cell sections and genetic approaches. Here, we directly visualise an unsuspected ‘single
Autor:
Wenling Wang, Huijuan Wang, Fei Ye, Yao Deng, Li Zhao, Taijiao Jiang, Wen Wang, Chongyu Su, Guizhen Wu, Weimin Zhou, Chaoyang Liang, Jingdong Song, Zhidong Liu, Baoying Huang, Wenjie Tan, Na Zhu, Longfei Mao, Jincun Zhao, Guangliang Qiang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize the replication dynamics, cell tropism and mo
Autor:
Namir Khalasawi, Zheng Dong, Congcong Yin, Xiaojun Wu, Qijun Yi, Frederic Geissmann, Qing-Sheng Mi, Li Zhou, James E. Glassbrook, Indra Adrianto, Queping Liu, Yi Yao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Alveolar macrophages (AMs) derived from embryonic precursors seed the lung before birth and self-maintain locally throughout adulthood, but are regenerated by bone marrow (BM) under stress conditions. However, the regulation of AM development and mai
Autor:
Stephen J. Haggarty, Bradford C. Dickerson, Diane Lucente, Dean G. Brown, Nicholas J. Brandon, Tanguy Jamier, Ian Gurrell, Ghata Nandi, Sharon Tentarelli, M. Catarina Silva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug disc
Autor:
Lauren E. Stopfer, Brian A. Joughin, Forest M. White, Douglas A. Lauffenburger, Joshua M Mesfin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an antitumor immune response in cancer. Surface MHC levels can be modulated by anticancer agents, altering immunity. Ho
Autor:
Tomoko Kubori, Hiroki Nagai, Joseph P. Vogel, Suk Youl Park, Hyunmin Kim, Byung-Ha Oh, Mi Jeong Kwak, Kohei Yamazaki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector proteins into host cells. This specialized secretion system employs the Dot/Icm type IVB coupling protein (T4CP) complex, which i
Autor:
W. June Brickey, Shao Cong Sun, Beckley K. Davis, Kaixin Liang, Jenny P.-Y. Ting, Lufei Wang, Jason W. Tam, Sirui Li, Yang Zhang, Alex Petrucelli, Haitao Guo, Brian J. Conti, Meng Deng, Ching-Chang Ko, Lu Zhang, Yu Lei, Xiaobo Luo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with the mitochondrial antiviral signaling
Autor:
Liang Jin, Wanli Zhao, Yue Yang, Bingbing Li, Tingsheng Liu, Dongshen Ma, Liu Yuhong, Fangfang Zhang, Yi Pan, Ling Li, Yanfeng Zhang, Hong Du, Jinming Mu, Changying Guo, Xianghui Fu, Zhengyu Cao, Yue Liu, Danwei Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
B cell dysfunction due to obesity can be associated with alterations in the levels of micro-RNAs (miRNAs). However, the role of miRNAs in these processes remains elusive. Here, we show that miR-802 is increased in the pancreatic islets of obese mouse
Autor:
Alan J. Mears, Jean-Marc Renaud, Jason R. Vanstone, Nadine J. Adam, Christine Péladeau, Adele Coriati, Hasanen Al-Rewashdy, Bernard J. Jasmin, Mohamed Thabet, Lucas Bronicki, Martin Holcik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Up-regulation of utrophin in muscles represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy. We previously demonstrated that eEF1A2 associates with the 5’UTR of utrophin A to promote IRES-dependent translation.
Autor:
Amelie J. Kraus, Benedikt G. Brink, Jens T. Vanselow, Stephanie Lamer, Andreas Schlosser, T. Nicolai Siegel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nat. Commun. 11:1498 (2020)
Nature Communications
Nat. Commun. 11:1498 (2020)
Despite histone H2A variants and acetylation of histones occurring in almost every eukaryotic organism, it has been difficult to establish direct functional links between canonical histones or H2A variant acetylation, deposition of H2A variants and t