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pro vyhledávání: ''
Autor:
Mineo Iwata, John A. Stamatoyannopoulos, Nikoletta Psatha, Grigorios Georgolopoulos, Andrew Nishida, Minas Yiangou, Jeff Vierstra, Tannishtha Som
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Lineage commitment and differentiation is driven by the concerted action of master transcriptional regulators at their target chromatin sites. Multiple efforts have characterized the key transcription factors (TFs) that determine the various hematopo
Autor:
Namir Khalasawi, Zheng Dong, Congcong Yin, Xiaojun Wu, Qijun Yi, Frederic Geissmann, Qing-Sheng Mi, Li Zhou, James E. Glassbrook, Indra Adrianto, Queping Liu, Yi Yao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Alveolar macrophages (AMs) derived from embryonic precursors seed the lung before birth and self-maintain locally throughout adulthood, but are regenerated by bone marrow (BM) under stress conditions. However, the regulation of AM development and mai
Autor:
Zechuan Liang, Wei Sun, Yongli Shan, Qianyu Chen, Wenhao Huang, Jiao Yao, Xiaofen Zhong, Duanqing Pei, Chuman Wu, Guangjin Pan, Shuquan Su, Chenxu Li, Tianyu Wang, Tian Zhang, Ke Huang, Cong Zhang, Baojian Liao, Jingyuan Zhang, Yanxing Wei, Mei Zhong, Jinfu Nie, Yanqi Zhang, Yanling Zhu, Yuan Zhao, Ning Ma, Zhenghui Su, Tiancheng Zhou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Neurogenesis, a highly orchestrated process, entails the transition from a pluripotent to neural state and involves neural progenitor cells (NPCs) and neuronal/glial subtypes. However, the precise epigenetic mechanisms underlying fate decision remain
Autor:
Cristina Fernández-Molina, Clément Crochemore, Audrey Salles, Miria Ricchetti, Benjamin Montagne
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.5576. ⟨10.1038/s41467-019-13314-y⟩
Nature Communications, 2019, 10, pp.5576. ⟨10.1038/s41467-019-13314-y⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.5576. ⟨10.1038/s41467-019-13314-y⟩
Nature Communications, 2019, 10, pp.5576. ⟨10.1038/s41467-019-13314-y⟩
Cellular senescence has causative links with ageing and age-related diseases, however, it remains unclear if progeroid factors cause senescence in normal cells. Here, we show that depletion of CSB, a protein mutated in progeroid Cockayne syndrome (CS
Autor:
Hideki Tanizawa, Rugang Zhang, Osamu Iwasaki, Andrew V. Kossenkov, Sanki Tashiro, Ken-ichi Noma, Louise C. Showe, Kyoung-Dong Kim, Sonali Majumdar, Timothy Nacarelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D
Autor:
Jiayu Wen, Paul Schedl, Malin Ueberschär, Chun Zhang, Shu Kondo, Tsutomu Aoki, Eric C. Lai, Huazhen Wang, Qi Dai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
The Drosophila genome encodes three BEN-solo proteins including Insensitive (Insv), Elba1 and Elba2 that possess activities in transcriptional repression and chromatin insulation. A fourth protein—Elba3—bridges Elba1 and Elba2 to form an ELBA com
Autor:
Gen Lin, Irina Grishkovskaya, Rushad Pavri, Alexander Stark, Anna Vlasova, Richard Štefl, Ursula E. Schoeberl, Melania Bruno, Carrie Bernecky, Lisa-Marie Appel, Vedran Franke, Martin Leeb, Aiste Kasiliauskaite, Carmen Ebenwaldner, Sebastian Kostrhon, Etienne Beltzung, Kristina Djinović-Carugo, Altuna Akalin, Tanja Kaufmann, Dea Slade, Marek Sebesta, Martin Puchinger, Karl Mechtler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 6078-1-6078-24 (2021)
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks ont
Autor:
Ben A. Johnson, Mary Rhodes, Jake J. Reske, Amanda L. Patterson, Marie Adams, Mike R. Wilson, José A. Teixeira, Jeanne Holladay, Julie Koeman, Hui Shen, Ronald L. Chandler, Ren-Wei Su, Asgerally T. Fazleabas, Niraj Joshi, Richard Leach, Genna E. Wilber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when combined with
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
The position, shape and number of transcription start sites (TSS) are critical determinants of gene regulation. Most methods developed to detect TSSs and study promoter usage are, however, of limited use in studies that demand quantification of expre
Autor:
Alexander V. Favorov, Joseph A. Califano, Nam Bui, Pablo Tamayo, Elana J. Fertig, John Pang, Kathleen M. Fisch, Trey Ideker, Yuki Saito, Daria A. Gaykalova, Chao Liu, Mizuo Ando, Patrick K. Ha, Adam Mark, Karen Messer, Tatsuya Yamasoba, Guorong Xu, Srinivasan Yegnasubramanian, Shuling Ren, Minya Pu, Akihiro Sakai, Takahito Fukusumi, Sunny Haft, Kate Medetgul-Ernar, Theresa Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional cha