Zobrazeno 1 - 10
of 40
pro vyhledávání: ''
Autor:
Mineo Iwata, John A. Stamatoyannopoulos, Nikoletta Psatha, Grigorios Georgolopoulos, Andrew Nishida, Minas Yiangou, Jeff Vierstra, Tannishtha Som
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Lineage commitment and differentiation is driven by the concerted action of master transcriptional regulators at their target chromatin sites. Multiple efforts have characterized the key transcription factors (TFs) that determine the various hematopo
Autor:
Alexander Kaltashov, Elodie L. Boulier, Jin Joo Kang, Elias Seif, Chongwoo A. Kim, Charles Sasseville, Ibani Kapur, Olga Senkovich, Nicole J. Francis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive Complex 1 (PRC1) subunit Polyhomeotic (Ph) has been shown to play an important role in c
Autor:
Xian J. Lian, Amr Omer, Imed-Eddine Gallouzi, Sergio Di Marco, Julian Lucas Moran, Monica Cruz Barrera, Christian Beauséjour
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet senescence is required for various physiological processes. However, the mechanisms and factors that control the negative effects of senescence while retaining its
Autor:
Hideki Tanizawa, Rugang Zhang, Osamu Iwasaki, Andrew V. Kossenkov, Sanki Tashiro, Ken-ichi Noma, Louise C. Showe, Kyoung-Dong Kim, Sonali Majumdar, Timothy Nacarelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D
Autor:
Jiayu Wen, Paul Schedl, Malin Ueberschär, Chun Zhang, Shu Kondo, Tsutomu Aoki, Eric C. Lai, Huazhen Wang, Qi Dai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
The Drosophila genome encodes three BEN-solo proteins including Insensitive (Insv), Elba1 and Elba2 that possess activities in transcriptional repression and chromatin insulation. A fourth protein—Elba3—bridges Elba1 and Elba2 to form an ELBA com
Autor:
Deshun Gong, Fudong Li, Yongrui Liu, Yunyu Shi, Yanxin Xu, Xudong Guo, Xuwen Chen, Wen Chen, Jiajing Chen, Qingtao Wei, Jiuhong Kang, Zikang Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Recognition of specific chromatin modifications by distinct structural domains within “reader” proteins plays a critical role in the maintenance of genomic stability. However, the specific mechanisms involved in this process remain unclear. Here
Autor:
Christine Ralf, Emily Graham, Isabel E. Wassing, Lucia Rampazzo, Andrew R. Bassett, Xanita Saayman, Fumiko Esashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The RAD51 recombinase plays critical roles in safeguarding genome integrity, which is fundamentally important for all living cells. While interphase functions of RAD51 in maintaining genome stability are well-characterised, its role in mitosis remain
Autor:
Ben A. Johnson, Mary Rhodes, Jake J. Reske, Amanda L. Patterson, Marie Adams, Mike R. Wilson, José A. Teixeira, Jeanne Holladay, Julie Koeman, Hui Shen, Ronald L. Chandler, Ren-Wei Su, Asgerally T. Fazleabas, Niraj Joshi, Richard Leach, Genna E. Wilber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when combined with
Autor:
Raja Jothi, Telmo Henriques, Christopher A. Lavender, Dhirendra Kumar, Senthilkumar Cinghu, Karen Adelman, Andrew J. Oldfield, Brian D. Bennett, Adam B. Burkholder, Pengyi Yang, Damien Paulet, Benjamin S. Scruggs, Eric Rivals
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Nature Communications, 2019, 10 (1), pp.3072. ⟨10.1038/s41467-019-10905-7⟩
Faithful transcription initiation is critical for accurate gene expression, yet the mechanisms underlying specific transcription start site (TSS) selection in mammals remain unclear. Here, we show that the histone-fold domain protein NF-Y, a ubiquito
Autor:
Alexander V. Favorov, Joseph A. Califano, Nam Bui, Pablo Tamayo, Elana J. Fertig, John Pang, Kathleen M. Fisch, Trey Ideker, Yuki Saito, Daria A. Gaykalova, Chao Liu, Mizuo Ando, Patrick K. Ha, Adam Mark, Karen Messer, Tatsuya Yamasoba, Guorong Xu, Srinivasan Yegnasubramanian, Shuling Ren, Minya Pu, Akihiro Sakai, Takahito Fukusumi, Sunny Haft, Kate Medetgul-Ernar, Theresa Guo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional cha