Zobrazeno 81 - 90
of 475
pro vyhledávání: ''
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Epistasis emerges when the effects of an amino acid depend on the identities of interacting residues. This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary paths and inform evolution of desired functions. However, the
Autor:
Oliver Purcell, Joshua Rees, Oliver Chalkley, Sophie Landon, Claire S. Grierson, Lucia Marucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
In the future, entire genomes tailored to specific functions and environments could be designed using computational tools. However, computational tools for genome design are currently scarce. Here we present algorithms that enable the use of design-s
Autor:
Nikolaos Vakirlis, Carlos J. Camacho, Trey Ideker, Cameron P. Hines, Nelson C. Coelho, Anne-Ruxandra Carvunis, Brian Hsu, Kate Medetgul-Ernar, Ray W. Bowman, Aoife McLysaght, Allyson F. O'Donnell, Saurin Bipin Parikh, Omer Acar, S. Branden Van Oss, Aaron C. Wacholder, John Iannotta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable
Autor:
Ken-ichi Noma, Kyoung-Dong Kim, Alessandra De Leo, Paul M. Lieberman, Louise C. Showe, Olga Vladimirova, Hideki Tanizawa, Fang Lu, Andrew V. Kossenkov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral encoded sequence-specific DNA binding protein. Here we employ circular
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.987. ⟨10.1038/s41467-020-14784-1⟩
Nature Communications, 2020, 11 (1), pp.987. ⟨10.1038/s41467-020-14784-1⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.987. ⟨10.1038/s41467-020-14784-1⟩
Nature Communications, 2020, 11 (1), pp.987. ⟨10.1038/s41467-020-14784-1⟩
Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The geno
Autor:
Diptavo Dutta, Adam Auton, Yanxiao Zhang, Nilanjan Chatterjee, Stephanie Glavaris, Alexis Battle, Bing Ren, Wei Wang, Neil C. Chi, Ali R. Keramati, Emmanouil Tampakakis, Marios Arvanitis, Wendy S. Post
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Heart failure is a major public health problem affecting over 23 million people worldwide. In this study, we present the results of a large scale meta-analysis of heart failure GWAS and replication in a comparable sized cohort to identify one known a
Autor:
Shaolong Cao, Valerae O. Lewis, P. Andrew Futreal, Wenyi Wang, Wei Lien Wang, Youyun Zheng, Alexandre Reuben, Patrick Hwu, Heather Lin, J. Andrew Livingston, Anthony P. Conley, Najat C. Daw, Shreyaskumar Patel, Hannah C. Beird, Alexander J. Lazar, Jason Roszik, Cheuk Hong Leung, Chia Chin Wu, Zhenlin Ju, Davis R. Ingram, Robert S. Benjamin, Neeta Somaiah, Shailesh Advani, Richard Gorlick, Akash Mitra, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, im
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Inhibition of transcription caused by DNA damage-impaired RNA polymerase II (Pol II) elongation conceals a local increase in de novo transcription, slowly progressing from Transcription Start Sites (TSSs) to gene ends. Although associated with accele
Autor:
Justin Whalley, Robert Bristow, Choon Kiat Ong, Samuel Aparicio, Paul Boutros, Raquel Rabionet, Elizabeth Christie, Markus Ringnér, Rosa Karlić, Shuto Hayashi, Sergei Yakneen, Vinayak Bhandari, Nigel Jamieson, Benedikt Brors, LUCA MALCOVATI
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Nature Communications
PCAWG Consortium 2020, ' Divergent mutational processes distinguish hypoxic and normoxic tumours ', Nature Communications, vol. 11, no. 1, pp. 737 . https://doi.org/10.1038/s41467-019-14052-x
Nature Communications, 11
Nature communications, vol 11, iss 1
Nature Communications, 11, 1
Nature Communications
PCAWG Consortium 2020, ' Divergent mutational processes distinguish hypoxic and normoxic tumours ', Nature Communications, vol. 11, no. 1, pp. 737 . https://doi.org/10.1038/s41467-019-14052-x
Nature Communications, 11
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific
Autor:
Amnon Koren, Marco Mariotti, Michelle L Hulke, Maxim V. Gerashchenko, Alaattin Kaya, Alexander Tyshkovskiy, Siming Ma, Xuming Zhou, Vadim N. Gladyshev
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Alteration of normal ploidy (aneuploidy) can have a number of opposing effects, such as unbalancing protein abundances and inhibiting cell growth but also accelerating genetic diversification and rapid adaptation. The interplay of these detrimental a