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of 281
pro vyhledávání: ''
Autor:
Yanting Huang, Thomas S. Wingo, Xiaobo Sun, Zhen Mei, Peng Jin, Aliza P. Wingo, Ronghua Li, Zhaohui S. Qin, Ekaterina S. Gerasimov, Chloe Robins, David A. Bennett, Xiaochuan Shi, Shaojun Yu, Matthew J Armstrong, Philip L. De Jager, Huige Jiang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Alzheimer’s disease (AD) is influenced by both genetic and environmental factors; thus, brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array-based Epigenome-Wide Association Studies (EWASs) have identified robust b
Autor:
John Michael Gaziano, Snehal Patil, Cassiane Robinson-Cohen, Thomas W. Winkler, Humaira Rasheed, Anna Köttgen, Christopher J. O'Donnell, Sarah E. Graham, Stein Hallan, Brett R Vanderweff, Kira J Stanzick, Cristian Pattaro, Matthias Wuttke, Bjørn Olav Åsvold, Iris M. Heid, Adriana M. Hung, Bryce X Rowan, Pascal Schlosser, Klaus Stark, VA Million Veteran Program, Cristen J. Willer, André Gessner, Yong Li, Mathias Gorski, Laurent F. Thomas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for creatinine-based estimated glomerular
Autor:
Fumihito Saitow, Shinji Tanaka, Janak R. Awasthi, Kota Tamada, François Spitz, Keita Fukumoto, Nobuhiro Nakai, Hidenori Suzuki, Tsuyoshi Toya, Toru Takumi, Shigeo Okabe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Maternally inherited duplication of chromosome 15q11-q13 (Dup15q) is a pathogenic copy number variation (CNV) associated with autism spectrum disorder (ASD). Recently, paternally derived duplication has also been shown to contribute to the developmen
Autor:
Antonio C. Bianco, Gustavo W. Fernandes, Tzintzuni Garcia, Tatiana L. Fonseca, T. Murlidharan Nair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
Autor:
Salil A. Lachke, Pirro G. Hysi, Ronald B. Melles, Deepti Anand, Hélène Choquet, Gabriel Cuellar-Partida, Jie Yin, Thomas J. Hoffmann, Wei Wang, K. Saidas Nair, Eric Jorgenson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Cataract is the leading cause of blindness among the elderly worldwide and cataract surgery is one of the most common operations performed in the United States. As the genetic etiology of cataract formation remains unclear, we conducted a multiethnic
Autor:
Chengzhi Li, Mengjie Wu, Ketao Jin, Yimin Lu, Haiyong Wang, Haibin Zhang, Junjie Jiang, Xiongfei Yu, Jing Zhang, Fei Teng, Tianhua Zhou, Donghui Zhou, Zhan Zhou, Yongfeng Ding, Mei Kong, Wenyi Zhao, Lisong Teng, Yanyan Chen, Yiran Chen, Yingying Huang, Haohao Wang, Zhongqi Li, Jun Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer. However, little is known about the genomic features of this disease. We perform whole-exome sequencing analysis of AFPGC, and identify 34 signif
Autor:
Ken Furudate, Keyur P. Patel, Tomoyuki Tanaka, Jairo Matthews, Xingzhi Song, Jianhua Zhang, Guowen Liu, Kyle J. MacBeth, Courtney D. DiNardo, Yuanqing Yan, Bin Wu, Hagop M. Kantarjian, Koichi Takahashi, Latasha Little, Kapil N. Bhalla, Guillermo Garcia-Manero, Kiyomi Morita, Elias J. Jabbour, Tapan M. Kadia, Marina Konopleva, Erika Thompson, Curtis Gumbs, Mark G. Frattini, P. Andrew Futreal, Farhad Ravandi, Feng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resis
Autor:
D. Stephen Charnock-Jones, Pieter-Jan Volders, Sungsam Gong, Francesca Gaccioli, Lennart Martens, Gordon C. S. Smith, Emma Cook, Ulla Sovio, Paul D. W. Kirk, Justyna Dopierala, Sylvia Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
NATURE COMMUNICATIONS
NATURE COMMUNICATIONS
Funder: Department of Health
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
High-throughput splicing assays have demonstrated that many exonic variants can disrupt splicing; however, splice-disrupting variants distribute non-uniformly across genes. We propose the existence of exons that are particularly susceptible to splice
Autor:
Wei Yuan, Pirro G. Hysi, Charles A. Mein, Elaine M. Dennison, Jordana T. Bell, Richard J. Acton, Fei Gao, Karen A. Lillycrop, Jun Wang, Eva Wozniak, Nicholas C Harvey, Yudong Xia, Tim D. Spector, Christopher G. Bell, Emma Bourne, Cyrus Cooper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are fundamental to the information flow from