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of 122
pro vyhledávání: ''
Autor:
Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;
Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Autor:
Fumihito Saitow, Shinji Tanaka, Janak R. Awasthi, Kota Tamada, François Spitz, Keita Fukumoto, Nobuhiro Nakai, Hidenori Suzuki, Tsuyoshi Toya, Toru Takumi, Shigeo Okabe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Maternally inherited duplication of chromosome 15q11-q13 (Dup15q) is a pathogenic copy number variation (CNV) associated with autism spectrum disorder (ASD). Recently, paternally derived duplication has also been shown to contribute to the developmen
Autor:
Chengzhi Li, Mengjie Wu, Ketao Jin, Yimin Lu, Haiyong Wang, Haibin Zhang, Junjie Jiang, Xiongfei Yu, Jing Zhang, Fei Teng, Tianhua Zhou, Donghui Zhou, Zhan Zhou, Yongfeng Ding, Mei Kong, Wenyi Zhao, Lisong Teng, Yanyan Chen, Yiran Chen, Yingying Huang, Haohao Wang, Zhongqi Li, Jun Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer. However, little is known about the genomic features of this disease. We perform whole-exome sequencing analysis of AFPGC, and identify 34 signif
Autor:
Ken Furudate, Keyur P. Patel, Tomoyuki Tanaka, Jairo Matthews, Xingzhi Song, Jianhua Zhang, Guowen Liu, Kyle J. MacBeth, Courtney D. DiNardo, Yuanqing Yan, Bin Wu, Hagop M. Kantarjian, Koichi Takahashi, Latasha Little, Kapil N. Bhalla, Guillermo Garcia-Manero, Kiyomi Morita, Elias J. Jabbour, Tapan M. Kadia, Marina Konopleva, Erika Thompson, Curtis Gumbs, Mark G. Frattini, P. Andrew Futreal, Farhad Ravandi, Feng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resis
Autor:
D. Stephen Charnock-Jones, Pieter-Jan Volders, Sungsam Gong, Francesca Gaccioli, Lennart Martens, Gordon C. S. Smith, Emma Cook, Ulla Sovio, Paul D. W. Kirk, Justyna Dopierala, Sylvia Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
NATURE COMMUNICATIONS
NATURE COMMUNICATIONS
Funder: Department of Health
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long a
Autor:
Wei Yuan, Pirro G. Hysi, Charles A. Mein, Elaine M. Dennison, Jordana T. Bell, Richard J. Acton, Fei Gao, Karen A. Lillycrop, Jun Wang, Eva Wozniak, Nicholas C Harvey, Yudong Xia, Tim D. Spector, Christopher G. Bell, Emma Bourne, Cyrus Cooper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are fundamental to the information flow from
Autor:
Tom Lesluyes, João Pedro de Magalhães, Peter Van Loo, Luminita Paraoan, Kasit Chatsirisupachai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Age is the most important risk factor for cancer, as cancer incidence and mortality increase with age. However, how molecular alterations in tumours differ among patients of different age remains largely unexplored. Here, using data from The Cancer G
Autor:
Pandurangan Vijayanand, Mitchell Kronenberg, Ashu Sethi, Mallory Paynich Murray, Jason A. Greenbaum, Ashmitaa Logandha Ramamoorthy Premlal, Sara Herrera-de la Mata, Isaac Engel, James P. Scott-Browne, Sandy Lucette Rosales, Grégory Seumois, Goo-Young Seo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets po
Autor:
Wenjing Li, Bingteng Xie, Rui Wu, Chunhong Liu, Na Zhang, Liang Leng, Chen Song, Mo Li, Yanyan Shi, Pan Wang, Xiaoyang Gu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
To date, a large number of mutations have been screened from breast and ovarian cancer patients. However, most of them are classified into benign or unidentified alterations due to their undetectable phenotypes. Whether and how they could cause tumor