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of 39
pro vyhledávání: ''
Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Autor:
Yanting Huang, Thomas S. Wingo, Xiaobo Sun, Zhen Mei, Peng Jin, Aliza P. Wingo, Ronghua Li, Zhaohui S. Qin, Ekaterina S. Gerasimov, Chloe Robins, David A. Bennett, Xiaochuan Shi, Shaojun Yu, Matthew J Armstrong, Philip L. De Jager, Huige Jiang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Alzheimer’s disease (AD) is influenced by both genetic and environmental factors; thus, brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array-based Epigenome-Wide Association Studies (EWASs) have identified robust b
Autor:
Antonio C. Bianco, Gustavo W. Fernandes, Tzintzuni Garcia, Tatiana L. Fonseca, T. Murlidharan Nair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific
Autor:
Ken Furudate, Keyur P. Patel, Tomoyuki Tanaka, Jairo Matthews, Xingzhi Song, Jianhua Zhang, Guowen Liu, Kyle J. MacBeth, Courtney D. DiNardo, Yuanqing Yan, Bin Wu, Hagop M. Kantarjian, Koichi Takahashi, Latasha Little, Kapil N. Bhalla, Guillermo Garcia-Manero, Kiyomi Morita, Elias J. Jabbour, Tapan M. Kadia, Marina Konopleva, Erika Thompson, Curtis Gumbs, Mark G. Frattini, P. Andrew Futreal, Farhad Ravandi, Feng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resis
Autor:
Wei Yuan, Pirro G. Hysi, Charles A. Mein, Elaine M. Dennison, Jordana T. Bell, Richard J. Acton, Fei Gao, Karen A. Lillycrop, Jun Wang, Eva Wozniak, Nicholas C Harvey, Yudong Xia, Tim D. Spector, Christopher G. Bell, Emma Bourne, Cyrus Cooper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are fundamental to the information flow from
Autor:
Tom Lesluyes, João Pedro de Magalhães, Peter Van Loo, Luminita Paraoan, Kasit Chatsirisupachai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Age is the most important risk factor for cancer, as cancer incidence and mortality increase with age. However, how molecular alterations in tumours differ among patients of different age remains largely unexplored. Here, using data from The Cancer G
Autor:
Shiv Pillai, Samuel J.H. Murphy, Vinay Mahajan, Hugues Allard-Chamard, Na Sun, Grace J. Yuen, Hamid Mattoo, Annaiah Cariappa, Vinayak Viswanadham, Maimuna Ahmad, Yesim Tuncay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways. The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here we profile the CpG modifications and transcriptomes of peritonea
Autor:
Zhou Zhang, Jeremy Ku, Alana V. Beadell, Geeta G Sharma, Urszula Dougherty, Zifeng Deng, Wei Zhang, Jason Karpus, Laura Sieh, Diana C. West-Szymanski, Francois Collin, Jiangbo Wei, Ji Nie, Patrick A. Arensdorf, Joel Pekow, Anna Bergamaschi, Christopher K. Ellison, Chuan He, Samuel Levy, Yuhong Ning, Xiaolong Cui, Ajay Goel, Marc Bissonnette, Raman Talwar, Carolyn W. T. Zhao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development and in human diseases. However, the lack of
Autor:
Chloe C. Y. Wong, Gokul Ramaswami, Jillian R. Haney, Michael J. Gandal, Jerry C. Wang, Daniel H. Geschwind, Jonathan Mill, Shyam Prabhakar, Wenjie Sun, Hyejung Won
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects
Autor:
Michael Schorpp, Norimasa Iwanami, Thomas Boehm, Connor O Meara, Divine-Fondzenyuy Lawir, Kohei Takeshita, Katarzyna Sikora
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the stage for transmission into future generations. Here, we describe a viable hypomorphic allele o