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Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele. However, if and how null ADPKD gene renal epithelial cells affect the
Autor:
Roland H Stimson, Neil Henderson, Marc R. Dweck, Cécile Bénézech, Zoi Michalidou, Calum C. Bain, Stephen J. Jenkins, Prakash Ramachandran, Laura Denby, Lucy H. Jackson-Jones, Marlene Magalhaes, Jordan R. Portman, Pete Smith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Magalhaes, M S, Smith, P, Portman, J, Jackson-Jones, L H, Bain, C C, Ramachandran, P, Michailidou, Z, Stimson, R H, Dweck, M R, Denby, L, Henderson, N C, Jenkins, S J & Benezech, C 2021, ' Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels ', Nature Communications . https://doi.org/10.1038/s41467-021-24684-7
Nature Communications
Magalhaes, M S, Smith, P, Portman, J, Jackson-Jones, L H, Bain, C C, Ramachandran, P, Michailidou, Z, Stimson, R H, Dweck, M R, Denby, L, Henderson, N C, Jenkins, S J & Benezech, C 2021, ' Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels ', Nature Communications . https://doi.org/10.1038/s41467-021-24684-7
Dyslipidemia is a main driver of cardiovascular diseases. The ability of macrophages to scavenge excess lipids implicate them as mediators in this process and understanding the mechanisms underlying macrophage lipid metabolism is key to the developme
Autor:
Lucas D. Ward, Ho-Chou Tu, Chelsea B. Quenneville, Shira Tsour, Alexander O. Flynn-Carroll, Margaret M. Parker, Aimee M. Deaton, Patrick A. J. Haslett, Luca A. Lotta, Niek Verweij, Manuel A. R. Ferreira, Regeneron Genetics Center, Geisinger-Regeneron DiscovEHR Collaboration, Aris Baras, Gregory Hinkle, Paul Nioi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Understanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful for
Autor:
Neha Seth, Amy Minnema, Miguel Hernandez Pampaloni, Amy Viehoever, Toni S. Pearson, Waldy San Sebastian, Ana Grijalvo-Perez, Shannon Lundy, Erin Smith, Russell R. Lonser, Krystof S. Bankiewicz, Jill Imamura-Ching, J. Bradley Elder, Jeffrey R. Leonard, Youngho Seo, Jill C. Heathcock, Keith Hyland, Gardenia de Oliveira Barbosa, Paul S. Larson, Alex J. Fay, Nalin Gupta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral,
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is c
Autor:
Gregor Andelfinger, Patrick van Vliet, Xiao-Yan Qi, Feng Xiong, Andrew T. Song, Jiening Xiao, Donghai Liu, Stanley Nattel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointesti
Autor:
Yungang Lu, Yong Xu, Jing Cai, Shengjie Fan, Qingchun Tong, Benjamin R. Arenkiel, Zhiying Jiang, Hongli Li, Mingshan Xue, Yuanzhong Xu, Cheng Huang, Qi Wu, Jessie C. Morrill
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Central leptin action rescues type 1 diabetic (T1D) hyperglycemia; however, the underlying mechanism and the identity of mediating neurons remain elusive. Here, we show that leptin receptor (LepR)-expressing neurons in arcuate (LepRArc) are selective
Autor:
Valery Grinevich, Anna-Lena Mayer, Alexandra Lorenz, Inga D. Neumann, Elisa Durante, Michael Lukas, Vinícius Elias de Moura Oliveira, Oliver J. Bosch, Veronica Egger, Anna Bludau, Trynke R. de Jong, Hannah Nora Wolf
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investigate the inv
Autor:
Su Chi Lim, Yaw Sing Tan, Su Fen Ang, Adrian Kee Keong Teo, Claire Wen Ying Neo, Shawn Hoon, Shirley Suet Lee Ding, Vidhya Gomathi Krishnan, Chandra S. Verma, Chang Siang Lim, E. Shyong Tai, Blaise Su Jun Low, Natasha Hui Jin Ng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3 (MODY3), characterized by insulin secretion defects. However, specific mechanisms of MODY3 in humans remain unclear due to lack of access to diseased human pancreatic
Autor:
Lu Liang, Kai Wang, Xinghui Chen, Zhiyuan Chen, Wei Wang, Marco Ajelli, Ziyan Liu, Kaiwei Luo, Yonghong Zhou, Huilin Shi, Hongjie Yu, Jinxin Guo, Wen Zheng, Alessandro Vespignani, Lidong Gao, Xinhua Chen, Yan Wang, Cécile Viboud, Lingshuang Ren, Han Yan, Jing Li, Maria Litvinova, Shixiong Hu, Kaiyuan Sun, Zhihong Deng, Mei Li, Ge Zeng, Hao Yang, Qianlai Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
medRxiv
Nature Communications
medRxiv
Several mechanisms driving SARS-CoV-2 transmission remain unclear. Based on individual records of 1178 potential SARS-CoV-2 infectors and their 15,648 contacts in Hunan, China, we estimated key transmission parameters. The mean generation time was es