Zobrazeno 1 - 10
of 435
pro vyhledávání: ''
Autor:
Rachit Badolia, Salah Sommakia, Aishwarya Aravamudhan, Aspasia Thodou Krokidi, Dipayan Chaudhuri, Thomas Gudermann, Paulina Sander, Kira Steinhorst, Ohyun Kwon, Stavros G. Drakos, Dinesh K. A. Ramadurai, Kenneth W. Spitzer, Sutip Navankasattusas, Andreas Dendorfer, Frank B. Sachse, Jing Ling, Emily H. Cheng, Thirupura S. Shankar, Johann Schredelseker, Dallen Calder, Kevin J. Whitehead, Changmin Xie, Oh Sung Kwon, Russel S. Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can
Autor:
Jun Xu, Jun-Ying Wang, Fang Luo, Min-Min Lou, Huan Zou, Yi Wu, Guangming Wang, Jia He, Guo-Ming Ma, Aibin Liang, Qun Zhang, Liu-Lin Xiong, Fei Wang, Qi-Li Shi, Ming-Jian Xu, Xiao-Qiang Tang, Yaoyang Zhang, Ting-Hua Wang, Jian Wang, Li-Bing Shen, Wenyuan Wang, Mingfeng Guan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we
Autor:
Joseph W. Dean, Lifeng Xiong, Timothy J. Garrett, Zongming E. Chen, Christian Jobin, Zheng Fu, Liang Zhou, Kristen N. Oliff, Michael Dougherty
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
RORγt+ lymphocytes, including interleukin 17 (IL-17)-producing gamma delta T (γδT17) cells, T helper 17 (Th17) cells, and group 3 innate lymphoid cells (ILC3s), are important immune regulators. Compared to Th17 cells and ILC3s, γδT17 cell metabo
Autor:
Antonio C. Bianco, Gustavo W. Fernandes, Tzintzuni Garcia, Tatiana L. Fonseca, T. Murlidharan Nair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific
Autor:
Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we sho
Autor:
Katy Lh Marshall-Phelps, Rebecca Frawley, Boguslawa Sadowski, Wiebke Möbius, Damien Marechal, Sunniva M. K. Bøstrand, Yong-hui Jiang, David A. Lyons, Patrizia Casaccia, Sarah Moyon, Dennis Huang, Linde Kegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, 2023, 12 (1), pp.3359. ⟨10.1038/s41467-021-23735-3⟩
Nature Communications
Nature Communications, 2023, 12 (1), pp.3359. ⟨10.1038/s41467-021-23735-3⟩
The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and d
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Autor:
Wenwei Hu, John J. Ponessa, Lanjing Zhang, Yuhan Zhao, Juan Liu, Zhaohui Feng, Chun Yuan Chang, Mark C. Siracusa, Jianming Wang, Fan Zhou, Huaying Wang, Xue Yang, Juan M. Inclan-Rico, Xuetian Yue, Ping Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity
Autor:
Birgit Kastberger, Adrien Joly, Ralph T. Böttcher, Reinhard Fässler, Zeynep Karatas, Bernhard Wehrle-Haller, Thomas Orré, Jean-Baptiste Sibarita, Clément Cabriel, Olivier Rossier, Sandrine Lévêque-Fort, Grégory Giannone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23372-w⟩
Nature Communications, Vol. 12, No 1 (2021) P. 3104
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23372-w⟩
Nature Communications, Vol. 12, No 1 (2021) P. 3104
Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Super-resolution microscopy revealed that FAs are organized at the nanoscale into functional layers from the lower
Autor:
James Dight, Sam L. Kahler, Edwige Roy, Ho Yi Wong, Jatin Patel, Hamish Hamilton, Racheal Wadlow, Mathias Francois, Isabella Hogan, Seen Ling Sim, Simranpreet Kaur, Laura Sormani, Kiarash Khosrotehrani, Mervin C. Yoder, Jilai Zhao, Ghazaleh Hashemi, Cassandra Styke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease, however its mechanism has yet to be elucidated. The endothelium possesses a profound regenerative capacity to adapt and reorganize that is attributed to a popul