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pro vyhledávání: ''
Autor:
Shaolong Cao, Valerae O. Lewis, P. Andrew Futreal, Wenyi Wang, Wei Lien Wang, Youyun Zheng, Alexandre Reuben, Patrick Hwu, Heather Lin, J. Andrew Livingston, Anthony P. Conley, Najat C. Daw, Shreyaskumar Patel, Hannah C. Beird, Alexander J. Lazar, Jason Roszik, Cheuk Hong Leung, Chia Chin Wu, Zhenlin Ju, Davis R. Ingram, Robert S. Benjamin, Neeta Somaiah, Shailesh Advani, Richard Gorlick, Akash Mitra, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, im
Autor:
Christopher C. Oakes, Elena Mylonas, Yusuke Shiozawa, Lars Bullinger, Matthias Obenaus, Daniel Noerenberg, Mareike Frick, Michaela Schwarz, Matthew J. J. Rose-Zerilli, Kenichi Yoshida, Friederike Christen, Yotaro Ochi, Willy Chan, Frederik Damm, Jaspal Kaeda, Philipp le Coutre, Yuichi Shiraishi, Seishi Ogawa, Thorsten Zenz, Birgit Sawitzki, Kaja Hoyer, Cornelius Hennch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor
Autor:
Bin Hu, Jingtao Qiu, Yi Shen, Ke Jin, Rohit R. Jadhav, Khushboo Sheth, Zhongde Ye, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show that CD4+ T cells from patients with RA and PsA have increased expression of the pore-forming
Autor:
Briana G. Nixon, Xiaojing Ma, Huan Wang, Mei Song, Junhua Mai, Oladapo Yeku, Tuo Zhang, Haifa Shen, Renier J. Brentjens, Sarwish Rafiq, Xue Dong, Terence J. Purdon, Lijing Zhu, Ziqi Yu, Ming O. Li
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular pathways involved in the OC-TME interactions,
Autor:
Christopher J. Logothetis, Yan Zhang, Mikhail G. Kolonin, Chieh Tseng, John M. Davis, Marsha L. Frazier, Elsa M. Li-Ning-Tapia, Olga Sirin, Curtis A. Pettaway, John M. Ward, Patricia Troncoso, Paul G. Corn, Tao Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications
Nature Communications
White adipose tissue (WAT) overgrowth in obesity is linked with increased aggressiveness of certain cancers. Adipose stromal cells (ASCs) can become mobilized from WAT, recruited by tumours and promote cancer progression. Mechanisms underlying ASC tr
Autor:
Jenny Chang-Claude, Christopher C. Oakes, Yassen Assenov, Marlon R. Veldwijk, David B. Liesenfeld, Christoph Rösli, Alla Slynko, Roger Sandhoff, Sabrina Hanke, Christoph Weigel, Petra Seibold, Mariona Rabionet, Elena Sperk, Axel Benner, Peter Schmezer, Odilia Popanda, Carsten Herskind, Frederik Wenz, Christoph Plass
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Radiotherapy is a fundamental part of cancer treatment but its use is limited by the onset of late adverse effects in the normal tissue, especially radiation-induced fibrosis. Since the molecular causes for fibrosis are largely unknown, we analyse if
Autor:
Sun Mi Park, Stephen D. Nimer, Benjamin H. Durham, Patrick Tivnan, Monica L. Guzman, Trevor S. Barlowe, Alexendar R. Perez, Tzu-Chieh Ho, Gail J. Roboz, Amit Verma, James Taggart, Michael G. Kharas, Minal Patel, Rachel Okabe, Omar Abdel-Wahab, Elianna M. Amin, Ly P. Vu, Christopher J. Lengner, Christopher Famulare, Christina S. Leslie, Arthur Chow, Virginia M. Klimek, Camila Prieto, Haiming Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications
Nature Communications
Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we de
Autor:
Michelangelo Fiorentino, Francesca Giunchi, Giovanni Parmigiani, Rosina T. Lis, Meir J. Stampfer, Clyde Bango, Chensheng Zhou, Michaela Bowden, Stephen P. Finn, Svitlana Tyekucheva, Ying Huang, Lorelei A. Mucci, Neil E. Martin, Massimo Loda, Arrigo Bondi, Stephen R. Pennington, Kathryn L. Penney, Ove Andrén, Sven Olof Andersson, Mieke Van Hemelrijck, R. William G. Watson
Publikováno v:
Tyekucheva, S, Bowden, M, Bango, C, Giunchi, F, Huang, Y, Zhou, C, Bondi, A, Lis, R, Van Hemelrijck, M, Andrén, O, Andersson, S O, Watson, R W, Pennington, S, Finn, S P, Martin, N E, Stampfer, M J, Parmigiani, G, Penney, K L, Fiorentino, M, Mucci, L A & Loda, M 2017, ' Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer ', Nature Communications, vol. 8, no. 1, 420 . https://doi.org/10.1038/s41467-017-00460-4
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we
Autor:
Thomas S. Wingo, Brittany L. Phillips, Bing Yao, Shi Chen, Mingjiang Xu, Janice Ortega, Li Chen, Feng Pan, Peng Jin, Miao Yu, Jaroslaw P. Maciejewski, Guangbo Qu, Guo Min Li, Hongyu Ni, Feng Chun Yang, Jianlong Wang, Zhigang Zhao, Hideki Makishima, Ophelia Weeks, Suming Huang, Jiapeng Wang, Tomas Radivoyevitch, Can Liu, Li Lin, Rui Gao, Iannis Aifantis, Aziz Nazha, Chuan He
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although TET2 mutations frequently occur in various types of haematological malignancies, the mechanism by which they increase risk for these cancers remains poorly un
Autor:
Agostino Ponzetti, Giulia Siravegna, Salvatore Siena, Beatriz Bellosillo, Federica Baldi, Filippo Pietrantonio, Federica Di Nicolantonio, Luca Lazzari, Alberto Bardelli, Benedetta Mussolin, Sabrina Arena, Giovanni Crisafulli, Alice Bartolini, Emanuele Valtorta, Beth O. Van Emburgh, Michela Buscarino, Giorgio Corti, Giovanni Germano, Andrea Sartore-Bianchi, Joan Albanell, Clara Montagut, Joana Vidal
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Blockade of the epidermal growth factor receptor (EGFR) with the monoclonal antibodies cetuximab or panitumumab is effective in a subset of colorectal cancers (CRCs), but the emergence of resistance limits the efficacy of these therapeutic agents. At