Zobrazeno 1 - 10
of 53
pro vyhledávání: ''
Autor:
Liqin Xu, Jia Fan, Yu Zhong, Miaomiao Jiang, Xiao-Rui Zhou, Yong Hou, Geng Liu, Min Du, Guibo Li, Shuang-Jian Qiu, Yuan Ji, Sun Yunfan, Xiangdong Wang, Bo Hu, Ashley R. Dennison, Sheng Liu, Ze-Fan Zhang, Qichao Yu, Xiaoyun Huang, Yang Xu, Ying-Hong Shi, David H. Peng, Wen-Yuan Chung, Kai-Qian Zhou, Nannan Li, Wei Guo, Liang Wu, Jian Zhou, Xin-Rong Yang, Hui-Chuan Sun, Michael Dean, Shiping Liu, Zhikun Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepa
Autor:
Shauli Talmor, Ignacio Mastandrea, Tova Waks, Zelig Eshhar, Liat Rousso-Noori, Dinorah Friedmann-Morvinski, Tambet Teesalu, Maarja Haugas, Luis Álvarez-Vallina, Anat Levin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Rousso-Noori, L, Mastandrea, I, Talmor, S, Waks, T, Globerson Levin, A, Haugas, M, Teesalu, T, Alvarez-Vallina, L, Eshhar, Z & Friedmann-Morvinski, D 2021, ' P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas ', Nature Communications, vol. 12, no. 1, 3615 . https://doi.org/10.1038/s41467-021-23817-2
Nature Communications
Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric patients. Despite decades of research no curative treatment is available and it thus remains associated with a very dismal prognosis. Although recent pre-clinic
Autor:
Zou Zizheng, Fan-Rong Kong, Chuanyu Yang, Chen Ling, Hu Xiyuan, Da-You Ma, Kun-Jian Peng, Xuan Li, Dong-Sheng Cao, Ceshi Chen, Tiao Luo, Zhengnan Ming, Wenjun Yi, Chen Xiaodan, Su-You Liu, Zhiyong Luo, Li Xia, Yuan-Zhu Xie, Jijia Li, Ousheng Liu, Junli Luo, Na Xu, Luo Wensong, Min Wen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency in patients leads to an autosomal recessive urea cycle disorder citrullinemia
Autor:
Yongliang Zhang, Heng Boon Low, Yik-Lam Cho, Herbert Schwarz, Nicholas R. J. Gascoigne, Fengchun Xiao, Chin Wen Png, Fiona Yi Xin Lee, Xiaohong Xu, Bangyuan Wu, Jia Min Loo, Han-Ming Shen, Li Ren Kong, Henry Yang, Ramanuj DasGupta, Zhen Lim Wong, Xuan Xin, Chun-Wei Li, Boon Cher Goh, Iain Beehuat Tan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast ca
Autor:
Fang Hua, Bing Cui, Yu-fen Yuan, Yang Xiao, Zaiwuli Yeerjiang, Chen-xi Zhao, Xiaowei Zhang, Ting-ting Zhang, Xiaoxi Lv, Jiao-jiao Yu, Zhao-na Yang, Shan-Shan Liu, Feng Wang, Zhuo-Wei Hu, Ke Li, Shuang Shang, Jin-mei Yu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homolog
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
Autor:
Liang Jin, Zijie Cai, Hongna Lai, Ying Li, Zongqi Wu, Erwei Song, Yujie Liu, Jingru Wang, Qiang Liu, Yudong Li, Mengdi Zhu, Shunying Li, Qianfeng Shi, Qian Li, Yanqing Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-r
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Autor:
Carlos Fernandez-del Castillo, Andrew S. Liss, Matteo Ligorio, Eric Tai, Chittampalli Yashaswini, A. W. K. Liu, David P. Ryan, Julia Philipp, Daniel A. Haber, Huili Zhu, Anupriya S. Kulkarni, Pavlos Missios, Elizabeth M. Tassoni, Joseph W. Franses, Theodore S. Hong, Niyati Desai, Annamaria Szabolcs, Irun Bhan, George Q. Daley, David T. Ting, Benjamin Nicholson, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-i
Autor:
M. Reza Sailani, Hongyan Guan, Jia Liu, Ming Yan, Nasa Sinnott-Armstrong, Pengju Lv, Eric A. Collisson, Yuanbo Cui, Aubhishek Zaman, Hongen Xu, Qinghe Xing, Jinwu Wang, Michael Snyder, Trever G. Bivona, Justin Chen, Pengli Han, Chang Jing, Jiancheng Guo, Wei Cao, Gundolf Schenk, Yanan Lou, Yuchi Gao, X B Sun, Alan Hunter Shain, Hayan Lee, Wenxue Tang, Sean R. McCorkle, Wei Wu, Lei Sun, Fred G. Biddle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We
Autor:
En-Chi Hsu, Hsin Yi Chen, Yu Ching Lee, Chun Ming Ho, Roger Shen, Hsi Wen Yeh, Yuh-Shan Jou, Jyun Wei Chen, Jou Ho Shih, Ruey-Hwa Chen, Yaw Dong Lang, Cheng Yen Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a lack
Autor:
Zhigang Li, Dandan Fan, Xiongjun Wang, Jianxiang Lin, Bo Ye, Jianzhong Su, Weiwei Xiong, Jian Yuan, Yunbo Qiao, Yuting Zhao, Qi Jiang, Min Li, Yilv Lv, Jie Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
The role of cis-elements and their aberrations remains unclear in esophageal squamous cell carcinoma (ESCC, further abbreviated EC). Here we survey 28 H3K27ac-marked active enhancer profiles and 50 transcriptomes in primary EC, metastatic lymph node