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Autor:
Luca Scorrano, Fred N. Ross-Cisneros, Alfredo A. Sadun, Martina Semenzato, Marta Zaninello, Francesca Grespi, Keiko Iwata, Konstantinos Palikaras, Ruben Quintana-Cabrera, Valerio Carelli, Stéphanie Herkenne, Deborah Naon, Nektarios Tavernarakis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
In autosomal dominant optic atrophy (ADOA), caused by mutations in the mitochondrial cristae biogenesis and fusion protein optic atrophy 1 (Opa1), retinal ganglion cell (RGC) dysfunction and visual loss occur by unknown mechanisms. Here, we show a ro
Autor:
Laura D. Attardi, Ciaran M. Lee, Kazuki Sawamoto, Rasmus O. Bak, Laure Aurelian, Rolen M. Quadros, Samantha G. Scharenberg, Matthew H. Porteus, Natalia Gomez-Ospina, Carlos Suárez, Sruthi Mantri, Shaukat Khan, Nitin Raj, Nathalie Mostrel, Shunji Tomatsu, Gang Bao, Channabasavaiah B. Gurumurthy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Gomez-Ospina, N, Scharenberg, S G, Mostrel, N, Bak, R O, Mantri, S, Quadros, R M, Gurumurthy, C B, Lee, C, Bao, G, Suarez, C J, Khan, S, Sawamoto, K, Tomatsu, S, Raj, N, Attardi, L D, Aurelian, L & Porteus, M H 2019, ' Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I ', Nature Communications, vol. 10, no. 1, 4045, pp. 4045 . https://doi.org/10.1038/s41467-019-11962-8
Nature Communications
Gomez-Ospina, N, Scharenberg, S G, Mostrel, N, Bak, R O, Mantri, S, Quadros, R M, Gurumurthy, C B, Lee, C, Bao, G, Suarez, C J, Khan, S, Sawamoto, K, Tomatsu, S, Raj, N, Attardi, L D, Aurelian, L & Porteus, M H 2019, ' Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I ', Nature Communications, vol. 10, no. 1, 4045, pp. 4045 . https://doi.org/10.1038/s41467-019-11962-8
Lysosomal enzyme deficiencies comprise a large group of genetic disorders that generally lack effective treatments. A potential treatment approach is to engineer the patient’s own hematopoietic system to express high levels of the deficient enzyme,
Autor:
Donghai Wang, Malin C. Erlandsson, Mohamed X. Ibrahim, Israiel T. Kumar, Christin Karlsson, Cord Brakebusch, Xiufeng Xu, Volkan I. Sayin, Maria Bokarewa, Omar M. Khan, Emil G. Ivarsson, Martin O. Bergo, Murali K. Akula, Mikael Brisslert
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Akula, M K, Ibrahim, M X, Ivarsson, E G, Khan, O M, Kumar, I T, Erlandsson, M, Karlsson, C, Xu, X, Brisslert, M, Brakebusch, C, Wang, D, Bokarewa, M, Sayin, V I & Bergo, M O 2019, ' Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions ', Nature Communications, vol. 10, no. 1, 3975, pp. 1-13 . https://doi.org/10.1038/s41467-019-11606-x
Nature Communications
Akula, M K, Ibrahim, M X, Ivarsson, E G, Khan, O M, Kumar, I T, Erlandsson, M, Karlsson, C, Xu, X, Brisslert, M, Brakebusch, C, Wang, D, Bokarewa, M, Sayin, V I & Bergo, M O 2019, ' Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions ', Nature Communications, vol. 10, no. 1, 3975, pp. 1-13 . https://doi.org/10.1038/s41467-019-11606-x
Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading of Rho proteins, lead
Autor:
Xiaoran Wei, Jianlin He, Ming-an Sun, Alicia M. Pickrell, Zhixiong Sun, Jianjun Chen, Alexander Murray, Alexei Morozov, Xiguang Xu, Michelle H. Theus, Xia Wang, Evan Xie, Jinsong Zhu, Xi Jiang, Liwu Li, Emmarose L. McCoig, Hehuang Xie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we predicted that Egr1, a transcr
Autor:
David P. Corey, Marcelo Cicconet, Hoor Al Jandal, Maryna V. Ivanchenko, Artur A. Indzhykulian, Xudong Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to
Autor:
Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan, Hong Zheng, Su Jung Song, Xiu Yin, Tao Han, Mengyu Xie, Qing Yin, Ming Chen, Shulong Jiang, Margaret R Little
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
The Anaphase Promoting Complex (APC) coactivator Cdh1 drives proper cell cycle progression and is implicated in the suppression of tumorigenesis. However, it remains elusive how Cdh1 restrains cancer progression and how tumor cells escape the inhibit
Autor:
Jana Karbanová, Chloe Bolton, Donald Singer, Ralf H. Adams, Stefano Ardu, Mengyuan Zhao, Yuxing Bai, Jemma Victoria Walker, Wai Ling Kok, Kishor K. Sivaraj, Qingguo Lai, Yan Gao, Moustapha Kassem, Heng Zhuang, Yuying Liu, Kai Yang, Portia Rebecca Clare Grayson, Christopher Tredwin, Basem M. Abdallah, Jihui Liu, Alexander C. Zambon, Shuo Chen, Bing Hu, Tim Lee, Denis Corbeil, Shuang Wang, Charlotte Sara Illsley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Walker, J V, Zhuang, H, Singer, D, Illsley, C S, Kok, W L, Sivaraj, K K, Gao, Y, Bolton, C, Liu, Y, Zhao, M, Grayson, P R C, Wang, S, Karbanová, J, Lee, T, Ardu, S, Lai, Q, Liu, J, Kassem, M, Chen, S, Yang, K, Bai, Y, Tredwin, C, Zambon, A C, Corbeil, D, Adams, R, Abdallah, B M & Hu, B 2019, ' Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation ', Nature Communications, vol. 10, no. 1, 3596 . https://doi.org/10.1038/s41467-019-11611-0
Nature Communications
Walker, J V, Zhuang, H, Singer, D, Illsley, C S, Kok, W L, Sivaraj, K K, Gao, Y, Bolton, C, Liu, Y, Zhao, M, Grayson, P R C, Wang, S, Karbanová, J, Lee, T, Ardu, S, Lai, Q, Liu, J, Kassem, M, Chen, S, Yang, K, Bai, Y, Tredwin, C, Zambon, A C, Corbeil, D, Adams, R, Abdallah, B M & Hu, B 2019, ' Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation ', Nature Communications, vol. 10, no. 1, 3596 . https://doi.org/10.1038/s41467-019-11611-0
Nature Communications
Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as
Autor:
Nadeem S. Bhat, Ahmed Gomaa, Andreia Bates, Xi Chen Steven, Dunfa Peng, Lihong Wang, Mohammed Soutto, Zheng Chen, Ajaz A. Bhat, M. Blanca Piazuelo, Wael El-Rifai, Richard M. Peek, M. Kay Washington, Abbes Belkhiri, Shoumin Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
TFF1, a secreted protein, plays an essential role in keeping the integrity of gastric mucosa and its barrier function. Loss of TFF1 expression in the TFF1-knockout (KO) mouse leads to a pro-inflammatory phenotype with a cascade of gastric lesions tha
Autor:
Rajgopal Govindarajan, Anne M. Strohecker, Bhawana Bissa, Craig A. McElroy, Avinash K. Persaud, Shanmugam Muruganandan, Aaron M. Beedle, Rakesh K. Pathak, Michelle M. Williams, Sreenath Nair, Radhika Raj, Amal Kaddoumi, Alex Sparreboom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Mutations exclusively in equilibrative nucleoside transporter 3 (ENT3), the only intracellular nucleoside transporter within the solute carrier 29 (SLC29) gene family, cause an expanding spectrum of human genetic disorders (e.g., H syndrome, PHID syn
Autor:
Li Chao, Tianzi Liuyu, Xi-Chen Huang, Wei Song, Run-Lei Du, Hui-Hui Zhang, Bing-Xue Jin, Yang Song, Xiao-Dong Zhang, Yi Liu, Bo Zhong, Shang-Ze Li, Qi-Peng Shu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral immune response during viral infection by targeting MAVS for degradati