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Autor:
Xiaoqing Liu, Ruomeng Li, Kaiyue Tan, Jie Wei, Chen Hong, Jing Liu, Haizhou Wang, Fuan Wang, Jinhua Shang, Xue Gong, Jing Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
The systemic therapeutic utilisation of RNA interference (RNAi) is limited by the non-specific off-target effects, which can have severe adverse impacts in clinical applications. The accurate use of RNAi requires tumour-specific on-demand conditional
Autor:
Shijie Zhang, Cong Jiang, Qiang Zhang, Jin-Rong Xu, Wei Wang, Qinhu Wang, Gengrui Zhu, Min Yan, Panpan Huang, Huiquan Liu, Yang Yang, Ruonan Hei
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Fusarium graminearum is a causal agent of Fusarium head blight (FHB) and a deoxynivalenol (DON) producer. In this study, OSP24 is identified as an important virulence factor in systematic characterization of the 50 orphan secreted protein (OSP) genes
Autor:
Steve Eyre, Magnus Rattray, Peyman Zarrineh, Antony Adamson, Paul Martin, Jing Yang, Peter Fraser, Xiangyu Ge, Andrew P. Morris, Kate Duffus, Amanda McGovern
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory
Autor:
Elaine C. Seaver, Laurel S. Hiebert, Long Jun Wu, Benjamin R. Bastin, Mark Q. Martindale, Yale J. Passamaneck, Stephan Schneider, Svetlana A. Maslakova, Marleen Klann, J. David Lambert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Spiralia is a large, ancient and diverse clade of animals, with a conserved early developmental program but diverse larval and adult morphologies. One trait shared by many spiralians is the presence of ciliary bands used for locomotion and feeding. T
Autor:
Ruiguo Chen, Qian Wu, Qiang Ma, Le Sun, Xin Zhou, Suijuan Zhong, Wenyu Ding, Xiaoqun Wang, Jing Liu, Zeyuan Liu, Honghai Peng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and h
Autor:
Kazuo Shin-ya, Junko Hashimoto, Mamoru Komatsu, Takehiro Nishimura, Noritaka Kagaya, Ikuko Kozone, Haruo Ikeda, Hikaru Suenaga, Kei Kudo, Reiko Ueoka, Takuya Hashimoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studi
Autor:
Helen C. Christian, Alexandre Mayran, Konstantin Khetchoumian, Jacques Drouin, Aurelio Balsalobre, Julie St-Pierre, Valérie Chénard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Translation is a basic cellular process and its capacity is adapted to cell function. In particular, secretory cells achieve high protein synthesis levels without triggering the protein stress response. It is unknown how and when translation capacity
Autor:
Sebastien Gagneux, Teresa Cortes, Iñaki Comas, Fernando González-Candelas, Douglas Young, Christine J. Boinett, William R. Jacobs, Álvaro Chiner-Oms, Julian Parkhill, Michael Berney
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
11 páginas, 6 figuras.
The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and
The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and
Autor:
Madeleine Huber, Christina Wehrheim, Sebastian Laass, Esther Kolbe, Kristina Seitz, Jörg Soppa, Guilhem Faure, Eugene V. Koonin, Yuri I. Wolf
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
The genomes of many prokaryotes contain substantial fractions of gene pairs with overlapping stop and start codons (ATGA or TGATG). A potential benefit of overlapping gene pairs is translational coupling. In 720 genomes of archaea and bacteria repres
Autor:
Michael Christie, Christina Piermaria, Nicolas Butel, Philippe Hammann, Patricia L. M. Lang, Johana Chicher, Carlos Gomez-Diaz, Detlef Weigel, Ezgi Süheyla Karaaslan, Hervé Vaucheret, David Pflieger, Lauriane Kuhn, Dominique Gagliardi, Heike Lange, Simon Y. A. Ndecky, Julie Zumsteg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, ⟨10.1038/s41467-019-11807-4⟩
Nature Communications (10), 1-12. (2019)
Nature Communications, Nature Publishing Group, 2019, 10, pp.1-12. ⟨10.1038/s41467-019-11807-4⟩
Nature Communications, 2019, 10, pp.1-12. ⟨10.1038/s41467-019-11807-4⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, ⟨10.1038/s41467-019-11807-4⟩
Nature Communications (10), 1-12. (2019)
Nature Communications, Nature Publishing Group, 2019, 10, pp.1-12. ⟨10.1038/s41467-019-11807-4⟩
Nature Communications, 2019, 10, pp.1-12. ⟨10.1038/s41467-019-11807-4⟩
The RNA exosome is a key 3’−5’ exoribonuclease with an evolutionarily conserved structure and function. Its cytosolic functions require the co-factors SKI7 and the Ski complex. Here we demonstrate by co-purification experiments that the ARM-rep