Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Autor:
Sebastien Gagneux, Teresa Cortes, Iñaki Comas, Fernando González-Candelas, Douglas Young, Christine J. Boinett, William R. Jacobs, Álvaro Chiner-Oms, Julian Parkhill, Michael Berney
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
11 páginas, 6 figuras.
The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and
The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and
Autor:
J Charalel, Marina Sirota, Katharine Yu, Christina Yau, Theodore C. Goldstein, Bin Chen, Denise M. Wolf, Atul J. Butte, Dvir Aran, L.J. van 't Veer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors. Here we present a comprehensive pan-cancer analysis utilizing transcriptomic profiles f
Autor:
Xiaoran Wei, Jianlin He, Ming-an Sun, Alicia M. Pickrell, Zhixiong Sun, Jianjun Chen, Alexander Murray, Alexei Morozov, Xiguang Xu, Michelle H. Theus, Xia Wang, Evan Xie, Jinsong Zhu, Xi Jiang, Liwu Li, Emmarose L. McCoig, Hehuang Xie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we predicted that Egr1, a transcr
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Genome-wide association studies (GWAS) have identified over 41 susceptibility loci associated with Parkinson’s Disease (PD) but identifying putative causal genes and the underlying mechanisms remains challenging. Here, we leverage large-scale trans
Autor:
Ashley S. Doane, Xabier Agirre, Olivier Elemento, Christopher E. Mason, Yanwen Jiang, Ari Melnick, Bruno Paiva, Zhuoning Li, José I. Martín-Subero, Leire Garate, Akanksha Verma, Felipe Prosper, Cem Meydan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
lncRNAs make up a majority of the human transcriptome and have key regulatory functions. Here we perform unbiased de novo annotation of transcripts expressed during the human humoral immune response to find 30% of the human genome transcribed during
Autor:
Tu-Lan Vu Han, Yi Wen Kong, Amanda Maffa, Qiuying Huang, Ekkehard M. Kasper, Fred C. Lam, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication colli
Autor:
Changyu Sun, Dong Won Kim, Lizhi Jiang, Zoe Qianyi Wang, Hong Wang, Basma Taleb Ismail, Seth Blackshaw, Parris Whitney Washington, Sonia Hao Lin
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Kim, D W, Washington, P W, Wang, Z Q, Lin, S H, Sun, C, Ismail, B T, Wang, H, Jiang, L & Blackshaw, S 2020, ' The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development ', Nature Communications, bind 11, nr. 1, s. 4360 .
Aarhus University
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Kim, D W, Washington, P W, Wang, Z Q, Lin, S H, Sun, C, Ismail, B T, Wang, H, Jiang, L & Blackshaw, S 2020, ' The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development ', Nature Communications, bind 11, nr. 1, s. 4360 .
Aarhus University
The hypothalamus is a central regulator of many innate behaviors essential for survival, but the molecular mechanisms controlling hypothalamic patterning and cell fate specification are poorly understood. To identify genes that control hypothalamic d
Autor:
Travis J. Meyers, Jun Shan, Thomas J. Hoffmann, Donglei Hu, Rajdeep Das, Stephen K. Van Den Eeden, John S. Witte, Felix Y. Feng, Joshua D. Hoffman, Elad Ziv, Linda Kachuri, Nima C. Emami
Publikováno v:
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evalu
Autor:
Richard J. Sinke, Lude Franke, Patrick Deelen, Sipko van Dam, Edgar T. Hoorntje, Jan D. H. Jongbloed, Roan Kanninga, Juha Karjalainen, Kristin M. Abbott, Wouter P. te Rijdt, Evelien Zonneveld-Huijssoon, Sabrina Z. Jan, Wilhelmina S. Kerstjens-Frederikse, Erica H. Gerkes, Pytrik Folkertsma, Morris A. Swertz, Harm Brugge, Yvonne J. Vos, Johanna C. Herkert, Jelkje J Boer-Bergsma, Peter C. van den Akker, Tessa Gillett, Birgit Sikkema-Raddatz, Conny M. A. van Ravenswaaij-Arts, Cleo C. van Diemen, Paul A. van der Zwaag, K. Joeri van der Velde
Publikováno v:
Nature Communications, 10(1):2837. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
The diagnostic yield of exome and genome sequencing remains low (8–70%), due to incomplete knowledge on the genes that cause disease. To improve this, we use RNA-seq data from 31,499 samples to predict which genes cause specific disease phenotypes,
Autor:
Emma Siragher, Anja Füllgrabe, Edward Ryder, Elisabeth M. Busch-Nentwich, James C. Smith, Wolfgang Weninger, Irene Papatheodoru, Neha Wali, Angela Green, Antonella Galli, Jacqueline K. White, Elizabeth J. Robertson, Myriam Hemberger, Amy Tang, David J. Adams, Stefan H. Geyer, Konstantinos Billis, Richard J. White, John E. Collins, Timothy J. Mohun, Nicole Staudt, Derek L. Stemple, Ian M Sealy, Cecilia Icoresi Mazzeo, Catherine Tudor, Ian Packham
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of embryonic lethality. Here we show t