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of 120
pro vyhledávání: ''
Autor:
Lucile Marion-Poll, Mikael Attia, Anne-Valerie Gendrel, Florian Massip, Ava C. Carter, Edith Heard, Dina Zielinski, Benjamin Forêt, Howard Y. Chang, Laurène Syx
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Most autosomal genes are thought to be expressed from both alleles, with some notable exceptions, including imprinted genes and genes showing random monoallelic expression (RME). The extent and nature of RME has been the subject of debate. Here we in
Autor:
Christian A. Lee, Adam J. Dupuy, Eldad Zacksenhaus, Daniel Dotzko, Susan J. Done, Nandini Raghuram, Nathan F. Schachter, Sean E. Egan, Amanda J. Loch, Rita M. Quintana, A. Sorana Morrissy, Giovanna Pellecchia, Ittai Ben-Porath, Charles M. Perou, Joanna Yang, Juhi S. Shah, Jennifer L. Gorman, Michael D. Taylor, Patryk Skowron, Jüri Reimand, Daria Wojtal, Jessica R. Adams, James R. Woodgett, Paul Leon-Gomez, Aaron Kucharczuk, Yeji An, Wei Wang, Katelyn. J. Kozma, Katherine L. Wright, Livia Garzia, Rotem Karni
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-speci
Autor:
Liran I. Shlush, John E. Dick, Philip Awadalla, Kimberly Skead, Boxi Lin, Quaid Morris, Stephen I. Wright, David Soave, Mawusse Agbessi, Armande Ang Houle, Vanessa Bruat, Sagi Abelson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Age-related clonal hematopoiesis (ARCH) is characterized by age-associated accumulation of somatic mutations in hematopoietic stem cells (HSCs) or their pluripotent descendants. HSCs harboring driver mutations will be positively selected and cells ca
Autor:
Raunak Shrestha, Eric J. Small, Felix Y. Feng, Jason T. Swinderman, Emily A. Egusa, Rajdeep Das, Alan Ashworth, David A. Quigley, Martin Sjöström, Christopher Yogodzinski, William S. Chen, Donna K. Dang, Junjie Tony Hua, Jonathan Chou, Luke A. Gilbert, Alex Y. Ge, Shaheen Kabir, Lisa N. Chesner
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genomic sequencing of thousands of tumors has revealed many genes associated with specific types of cancer. Similarly, large scale CRISPR functional genomics efforts have mapped genes required for cancer cell proliferation or survival in hundreds of
Autor:
Wei Perng, Laura Smale, Claudia Lalancette, Maggie A. Sawdy, Malit O. Pioon, Karthik R. Padmanabhan, Tracy M. Montgomery, Zachary M. Laubach, Julie W. Turner, Christopher Faulk, Bridgett M. vonHoldt, Kay E. Holekamp, Raymond G. Cavalcante, Julia R. Greenberg, Dana C. Dolinoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Studies in rodents and captive primates suggest that the early-life social environment affects future phenotype, potentially through alterations to DNA methylation. Little is known of these associations in wild animals. In a wild population of spotte
Autor:
Siqin Ge, Jinbo Wang, Yong Zhang, Xun Huang, Hua Chen, Shengjun Tan, Chun-Long Chen, Huijing Ma, Jieyu Shen, Danyang Wang, Zhihua Zhang, Xinying Zhang, Haodong Yin, Yaqiong Zhang, Man Wang, Jianmin Wu, Graham L. Banes, Mengxia Wang
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24585-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24585-9⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Despite long being considered as “junk”, transposable elements (TEs) are now accepted as catalysts of evolution. One example is Mutator-like elements (MULEs, one type of terminal inverted repeat DNA TEs, or TIR TEs) capturing sequences as Pack-MU
Autor:
Jan Tebbe, Florian Richter, Sarah J. Spencer, Karolina A. Kosakowska, Wayne Coco, Christien Bednarski, Cindy Park-Windhol, Abraham Scaria, Michael Biag Gamalinda, Ryo Takeuchi, Scott Munzer, Akiko Noma, Albena Kantardzhieva, Andre Cohnen, Michael Lukason, Mariacarmela Allocca, Caroline W. Reiss, Andrew M. Scharenberg, Brian J. Cafferty, Christian Pitzler, Stefanie Gehrig-Giannini, Kui Wang, Ashish Gupta, Kerstin Dehne, Sane Shailendra, Christina Galonska, Moritz Schmidt, Christopher J. Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are an alterna
Autor:
Nayomi Illansinhage Don, Scott P. Collins, Roberto Galizi, Andrea Crisanti, Chrysanthi Taxiarchi, Chase L. Beisel, Matthew Gribble, Andrea Beaghton, Dammy Shittu, Kyros Kyrou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature communications
England
Nature Communications
Nature communications
England
Nature Communications
CRISPR-based gene drives offer promising means to reduce the burden of pests and vector-borne diseases. These techniques consist of releasing genetically modified organisms carrying CRISPR-Cas nucleases designed to bias their inheritance and rapidly
Autor:
Zhengrong Xu, Longzhi Tan, Clemens Riegler, Mustafa Talay, Cheng Yang, X. Sunney Xie, Wanqing Wu, Hui Yang, Cheng Tang, Mark Johnson, Xiaona Huo, Hongqiang Bao, Kristian J. Herrera, Stephen D. Liberles, Florian Engert, Gilad Barnea, Qian Li, Aimei Fei, Yalei Kong, Griffin Hartmann
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique odorant receptor (OR). Mechanisms underlying singular OR expression are well studied, and involve a massive cross-chromosomal enhancer interaction network. Trac
Autor:
Ahmed N. Alkanaq, Muneko Kataoka, Mizuho Ishiwata, An-a Kazuno, Naomichi Matsumoto, Nana Matoba, Tadafumi Kato, Toru Sengoku, Kohei Hamanaka, Masaki Nishioka, Kumiko Fujii, Nakao Iwata, Naomi Sakai, Takashi Hayama, Takashi Oka, Takumi Nakamura, Takashi Tsuboi, Masashi Ikeda, Kazuhiro Ogata, Koji Matsuo, Atsushi Takata, Yoshinori Watanabe, Atsuko Komori
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Bipolar disorder is a severe mental illness characterized by recurrent manic and depressive episodes. To better understand its genetic architecture, we analyze ultra-rare de novo mutations in 354 trios with bipolar disorder. For germline de novo muta