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pro vyhledávání: ''
Autor:
Adrian Salic, Wanqiu Li, Wenchen Liu, Sisi Li, Feitong Dong, Bradley M. Wierbowski, Peiyi Wang, Mo Lu, Linlin Wang, Xin Gong
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing
Autor:
Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M.M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W.E. Santen, Marco Trizzino
Publikováno v:
Nature Communications
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subunit switches in the BAF chromatin remodeler are essential during development. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause neurodevelopmental disorders, including Coffi
Autor:
Klaus M. Hahn, Shichen Shen, Jules Berlin Nde Kengne, Rebecca M. Wombacher, Anna Bianchi-Smiraglia, Mikhail A. Nikiforov, Jun Qu, Zhiyong Deng, Daniel J. Marston, Eugene S. Kandel, Zhannan Han, Cristina M. Furdui, Bernard Fongang, Dong Hyun Yun, Mikhail E. Kandel, Edward Hurley, Maria Laura Feltri, Anderson O’Brien Cox, Ashley L. Mussell, Jialin Chen, Thomas Hollis, Sudha Moparthy, David W. Wolff, Rui J Sousa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than th
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
GABAA receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic inhibition. However, the mechanisms underlying spontaneity are poorly understood. Here we demonstrat
Autor:
Robert Köchl, Simon Brayford, Shamsinar Jalal, Simon Ameer-Beg, Fuad Mosis, Lawrence Yolland, Simon P. Poland, Maia Rowe-Sampson, Matthias Krause, Tommy Pallett, Ah-Lai Law, James A. Levitt, Stefania Marcotti, Ahmad Guni, Giordano Pula, Anett Jandke, Brian Stramer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activ
Autor:
Hyemi Shin, Jae Myoung Suh, Myeong-Gyun Kang, Kwang-Eun Kim, Won Gun Choi, Hyun-Woo Rhee, Jong-Seo Kim, Isaac Park, Jeesoo Kim
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Secretory proteins are an essential component of interorgan communication networks that regulate animal physiology. Current approaches for identifying secretory proteins from specific cell and tissue types are largely limited to in vitro or ex vivo m
Autor:
Heling Pan, Ying Li, Zhangdan Xie, Lauren Mifflin, Zheng-Jiang Zhu, Chengyu Zou, H. Wang, Junying Yuan, Mengmeng Zhang, Weiwei Qi, Zhen Liu, Bing Shan, Masanori Gomi Naito, Ayaz Najafov
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by phosphorylating VPS26B. NEK1 deficien
Autor:
Jean Duchaine, Stéphane A. Laporte, Etienne Khoury, Alexandre Beautrait, Yoon Namkung, Michel Bouvier, Mónica Lara-Márquez, Tomasz Maciej Stepniewski, Doris A. Schuetz, Audrey Claing, Olivier Radresa, Sylvain Armando, Anne Marinier, Nathalie Lamarche-Vane, Jana Selent, Jenna Giubilaro, Shirley Campbell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play pivotal roles in cell responsiveness. Dysregulation in receptor trafficking can lead to aberrant signaling and cell behavior. Here, using an endosomal BRET-base
Autor:
Nick D. Bergkamp, Martine J. Smit, Truc Giap, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Timo W.M. De Groof, Maarten P. Bebelman, Richard de Goeij de Haas, Raimond Heukers, Sander R. Piersma, Marco Siderius
Publikováno v:
Nature Communications
Nature Communications, 12(1):4357. Nature Publishing Group
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, pp. 4357 . https://doi.org/10.1038/s41467-021-24574-y
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1). Nature Publishing Group UK
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, 4357 . https://doi.org/10.1038/s41467-021-24574-y
Nature Communications, 12(1):4357. Nature Publishing Group
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, pp. 4357 . https://doi.org/10.1038/s41467-021-24574-y
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 12(1). Nature Publishing Group UK
De Groof, T W M, Bergkamp, N D, Heukers, R, Giap, T, Bebelman, M P, Goeij-de Haas, R, Piersma, S R, Jimenez, C R, Garcia, K C, Ploegh, H L, Siderius, M & Smit, M J 2021, ' Selective targeting of ligand-dependent and-independent signaling by GPCR conformation-specific anti-US28 intrabodies ', Nature Communications, vol. 12, no. 1, 4357 . https://doi.org/10.1038/s41467-021-24574-y
While various GPCRs, including US28, display constitutive, ligand-independent activity, it remains to be established whether ligand-dependent and -independent active conformations differ and can be selectively modulated. Previously, the agonist-bound
Autor:
Ulrike Lorenz, Shih Yi Guo, Christopher B. Medina, Yu-Hsin Chiu, Adishesh K. Narahari, Bimal N. Desai, Douglas A. Bayliss, Hong-Yu Gao, Elizabeth C. Gonye, Catherine A. Doyle, Joanna K. Sandilos, Mahmut Parlak, Thomas P. Conrads, Ming-Ming Zhou, Kodi S. Ravichandran
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Activation of Pannexin 1 (PANX1) ion channels causes release of intercellular signaling molecules in a variety of (patho)physiological contexts. PANX1 can be activated by G protein-coupled receptors (GPCRs), including α1-adrenergic receptors (α1-AR