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Autor:
Michael F. Press, Ali Madani, Nitish Shirish Keskar, David B. Agus, Daniel Ruderman, Nikhil Naik, Richard Socher, Andre Esteva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular marker used for prognosis and treatment decisions. During clinical management, ERS is determined by pathologists from immunohistochemistry (IHC) staining of biopsied
Autor:
Shuohan Wu, Junqiu Xie, Lili Jiang, Runfeng Lin, Rui Wang, Sihua Hong, Nazi Song, Hongjiao Xu, Xianxing Jiang, Qian Zhao, Zhibin Yan, Huihao Zhou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors
Autor:
R. Stephanie Huang, Alexander Ling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Evidence has recently emerged that many clinical cancer drug combinations may derive their efficacy from independent drug action (IDA), where patients only receive benefit from the single most effective drug in a drug combination. Here we present IDA
Autor:
Ze-Lin Li, Ji-Hong Liu, Xin-Hong Zhu, Qiang-Long You, Xiaochun Bai, Neng-Yuan Hu, Yan Wang, Jian-Ming Yang, Jiang-Ping Xu, Shu-Ji Li, Zeng-Lin Jin, Tian-Ming Gao, Yifan Dai, Qian Wang, Xiao-Wen Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on n
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Autor:
Costantino Pitzalis, Esteban A. Gomez, Conrad Bessant, Romain A. Colas, Rebecca Hands, Myles Lewis, Patricia R. Souza, Jesmond Dalli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral
Autor:
Liam R. Brunham, Chad M. Brummett, Natalia Fendrikova-Mahlay, Million Veteran Program, Chang Xu, Christopher J. O'Donnell, Catherine Tcheandjieu, Kristina L. Hunker, Ellen M. Schmidt, Kirby Swan, Jacqueline Saw, Heather L. Gornik, Themistocles L. Assimes, Dawn M. Coleman, Sebastian Zoellner, Mark Trinder, Isabelle Birt, Jun Li, Xiang Zhou, Andrew Starovoytov, Michael R. Mathis, Santhi K. Ganesh, Min-Lee Yang, Alexander Katz, Linda A. Jackson, James C. Stanley, Matthew Zawistowski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (Ncases = 270/Ncontrols = 5,263) and identified and replicated
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Autor:
Charlotte Hansen, Marcus Altfeld, Claudia Marggraff, Jill Noll, Stefan Hoenow, Iris Bruchhaus, Nahla Galal Metwally, Marie Weskamm, Marie Groneberg, Christoph Dorn, Stephanie Stanelle-Bertram, Svenja Kuehl, Harald Ittrich, Thomas Jacobs, Sven Hendrik Hagen, Julie Sellau, Egbert Tannich, Julia Wernecke, Vincent Wolf, Helena Fehling, Thorsten Thye, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of
Autor:
Claudia Pedroza, Shree Mohan, Chaim Putterman, Ting Zhang, Evan Der, Deena Habazi, Kamala Vanarsa, Gabriel Gidley, Hemant Suryawanshi, Thomas Tuschl, Samar Soliman, Michelle Petri, Samantha Stanley, Ramesh Saxena, Chandra Mohan, Jill P. Buyon, Chi Chiu Mok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Emerging urinary biomarkers continue to show promise in evaluating lupus nephritis (LN). Here, we screen urine from active LN patients for 1129 proteins using an aptamer-based platform, followed by ELISA validation in two independent cohorts comprise