Zobrazeno 1 - 10
of 28
pro vyhledávání: ''
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Autor:
Claudio Grassi, Cristian Ripoli, Marco Rinaudo, Salvatore Fusco, Sara Cocco, Alessia Mastrodonato, Matteo Spinelli, Francesca Natale, Giulia Livrizzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Metabolic diseases harm brain health and cognitive functions, but whether maternal metabolic unbalance may affect brain plasticity of next generations is still unclear. Here, we demonstrate that maternal high fat diet (HFD)-dependent insulin resistan
Autor:
Qing Gao, Luke Norton, Yuejuan Qin, Chris E. Shannon, Zi Ming Cheng, Muhammad A. Abdul-Ghani, Balakuntalam S. Kasinath, Anqi Luo, Nathan Harper, Xingyu Zhang, Marcel Fourcaudot, Patricia L. M. Dahia, Ricardo C.T. Aguiar, Subramanya Srikantan, Sifan Tao, Robert L. Reddick, Stephen Harrison, Sunil K. Ahuja, Zhi Li, Glaiza Mae Sande-Docor, Yilun Deng, Lily Q. Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Understanding the molecular components of insulin signaling is relevant to effectively manage insulin resistance. We investigated the phenotype of the TMEM127 tumor suppressor gene deficiency in vivo. Whole-body Tmem127 knockout mice have decreased a
Autor:
Hiroaki Adachi, Naohide Kondo, Masahisa Katsuno, Madoka Iida, Shinobu Shimizu, Yohei Okada, Yutaka Tsutsumi, Gen Sobue, Hideaki Nakatsuji, Masahiro Nakatochi, Ayuka Murakami, Seiya Noda, Kentaro Sahashi, Yuka Tsukagoshi Okabe, Hideyuki Okano, Masaaki Mizuno, Kazunari Onodera, Genki Tohnai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor (AR) gene. Here, we perform a comprehensive analysis of signaling pathways in a mouse model of SBMA (AR-97Q mice) utilizing
Autor:
Angelo D'Alessandro, Eugenia Mileykovskaya, Marvin Wirianto, Youqiong Ye, Zheng Chen, Karyn A. Esser, Venkata K. P. S. Mallampalli, William Dowhan, Leng Han, Jiah Yang, Joseph S. Takahashi, Carla B. Green, Travis Nemkov, Yuxiang Sun, Kazunari Nohara, Seung Hee Yoo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Circadian disruption aggravates age-related decline and mortality. However, it remains unclear whether circadian enhancement can retard aging in mammals. We previously reported that the small molecule Nobiletin (NOB) activates ROR (retinoid acid rece
Autor:
Xuqi Chen, Patrick Tso, Ryan E. Temel, Sean E. Thatcher, Pan Deng, Michael C. Petriello, Xuping Wang, Wendy S. Katz, Yasir Alsiraj, Heba Ali, Eric M. Blalock, Lisa A. Cassis, Katherine L. Thompson, Aldons J. Lusis, Karen Reue, Andrew J. Morris, Arthur P. Arnold, Lei Cai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effect
Autor:
Vaibhav Saini, Khalid S. Mohammad, Levi Matthies, Courtney L. Long, Hiroaki Saito, Andre J. van Wijnen, Simona Bolamperti, Hartmut Schlüter, Miki Maeda, Marcel Kwiatkowski, Paola Divieti Pajevic, Andreas Gasser, Katharina Jähn, Hanna Taipaleenmaki, Theresa A. Guise, Teresita Bellido, Eric Hesse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Osteoporosis is caused by increased bone resorption and decreased bone formation. Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast-mediated bone formation and is used in patients with severe osteoporosis. Ho
Autor:
Everard, Amandine, Plovier, Hubert, Rastelli, Marialetizia, Van Hul, Matthias, de Wouters d'Oplinter, Alice, Geurts, Lucie, Druart, Céline, Robine, Sylvie, Delzenne, Nathalie, Muccioli, Giulio, De Vos, Willem, Luquet, Serge, Flamand, Nicolas, Di Marzo, Vincenzo, Cani, Patrice, de Wouters d’Oplinter, Alice
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.457. ⟨10.1038/s41467-018-08051-7⟩
Nature Communications, 10(1)
Nature Communications 10 (2019) 1
Nature Communications, Vol. 10, p. 457 [1-17] (2019)
Nature communications 10 (2019): 1–17. doi:10.1038/s41467-018-08051-7
info:cnr-pdr/source/autori:Everard, Amandine; Plovier, Hubert; Rastelli, Marialetizia; Van Hul, Matthias; d'Oplinter, Alice de Wouters; Geurts, Lucie; Druart, Celine; Robine, Sylvie; Delzenne, Nathalie M.; Muccioli, Giulio G.; de Vos, Willem M.; Luquet, Serge; Flamand, Nicolas; Di Marzo, Vincenzo; Cani, Patrice D./titolo:Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis/doi:10.1038%2Fs41467-018-08051-7/rivista:Nature communications/anno:2019/pagina_da:1/pagina_a:17/intervallo_pagine:1–17/volume:10
Nature Communications, 2019, 10 (1), pp.457. ⟨10.1038/s41467-018-08051-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.457. ⟨10.1038/s41467-018-08051-7⟩
Nature Communications, 10(1)
Nature Communications 10 (2019) 1
Nature Communications, Vol. 10, p. 457 [1-17] (2019)
Nature communications 10 (2019): 1–17. doi:10.1038/s41467-018-08051-7
info:cnr-pdr/source/autori:Everard, Amandine; Plovier, Hubert; Rastelli, Marialetizia; Van Hul, Matthias; d'Oplinter, Alice de Wouters; Geurts, Lucie; Druart, Celine; Robine, Sylvie; Delzenne, Nathalie M.; Muccioli, Giulio G.; de Vos, Willem M.; Luquet, Serge; Flamand, Nicolas; Di Marzo, Vincenzo; Cani, Patrice D./titolo:Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis/doi:10.1038%2Fs41467-018-08051-7/rivista:Nature communications/anno:2019/pagina_da:1/pagina_a:17/intervallo_pagine:1–17/volume:10
Nature Communications, 2019, 10 (1), pp.457. ⟨10.1038/s41467-018-08051-7⟩
Variations in N-acylethanolamines (NAE) levels are associated with obesity and metabolic comorbidities. Their role in the gut remains unclear. Therefore, we generated a mouse model of inducible intestinal epithelial cell (IEC)-specific deletion of N-
Autor:
Akihiro Yamanaka, Hiromi Yokota-Hashimoto, Ayumu Inutsuka, Akihiro Harada, Takayoshi Suga, Daisuke Kohno, Tadahiro Kitamura, Masaki Kobayashi, Takashi Nakagawa, Sho Matsui, Tsutomu Sasaki, Tatsushi Onaka, Keisuke Yaku, Osamu Kikuchi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetyla
Autor:
Andrea Geisz, Miklós Sahin-Tóth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the