Zobrazeno 1 - 10
of 15
pro vyhledávání: ''
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Autor:
Theodore P. Ciaraldi, Inês S. Lima, Yossi Dagon, Ji A Seo, Achana Vijyakumar, Jee In Heo, Vanita R. Aroda, Robert R. Henry, Hu Huang, Min-Cheol Kang, Won Mo Yang, Kyong Soo Park, Aykut Göktürk Üner, Soo Hong, Won Min Hwang, Sang Soo Kim, Leandro Pereira de Moura, Min Seon Kim, Thomas E. Willnow, Seung-Hwan Lee, Young-Bum Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (Apo
Autor:
Robert Wagner, Martin Heni, Valenta, Juergen Machann, Hubert Preissl, Otto Tschritter, Stephanie Kullmann, Andreas Fritsche, HU Häring
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nat. Commun. 11:1841 (2020)
European Journal of Nuclear Medicine and Molecular Imaging
Nat. Commun. 11:1841 (2020)
European Journal of Nuclear Medicine and Molecular Imaging
Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown.
Autor:
Qing Gao, Luke Norton, Yuejuan Qin, Chris E. Shannon, Zi Ming Cheng, Muhammad A. Abdul-Ghani, Balakuntalam S. Kasinath, Anqi Luo, Nathan Harper, Xingyu Zhang, Marcel Fourcaudot, Patricia L. M. Dahia, Ricardo C.T. Aguiar, Subramanya Srikantan, Sifan Tao, Robert L. Reddick, Stephen Harrison, Sunil K. Ahuja, Zhi Li, Glaiza Mae Sande-Docor, Yilun Deng, Lily Q. Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Understanding the molecular components of insulin signaling is relevant to effectively manage insulin resistance. We investigated the phenotype of the TMEM127 tumor suppressor gene deficiency in vivo. Whole-body Tmem127 knockout mice have decreased a
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Autor:
Jie Ding, Ruping Sun, Helen Bardwell, Suet-Feung Chin, Akshara Singareeka Raghavendra, Michael F. Press, Johannes G. Reiter, Carlos Suárez, Jennifer L. Caswell-Jin, Robert B. West, Zheng Hu, Debasish Tripathy, Carlos Caldas, Christina Curtis, Zhicheng Ma, Katherine McNamara, Elena Provenzano, Julie E. Lang, Susanne Tilk, Victoria Forte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that appare
Autor:
Sophie C. Hamr, T.M. Zaved Waise, Mona A. Abraham, Tony K.T. Lam, Paige V. Bauer, Helen J. Dranse, Brittany A. Rasmussen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
High protein feeding improves glucose homeostasis in rodents and humans with diabetes, but the mechanisms that underlie this improvement remain elusive. Here we show that acute administration of casein hydrolysate directly into the upper small intest
Autor:
Yanhui Zhang, Saachi Pai, Ashutosh Kumar, Litao Xie, Susheel K. Gunasekar, Samuel B. Stephens, Andrew W. Norris, Anil Mishra, Rajan Sah, Yiwen Gao, Chen Kang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Insulin secretion is initiated by activation of voltage-gated Ca2+ channels (VGCC) to trigger Ca2+-mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC requires β-cell membrane depolarization, which is regulated by a
Autor:
Gopa Iyer, Jonathan E. Rosenberg, Philip Abbosh, Brendan Reardon, Joaquim Bellmunt, Scott L. Carter, Jean H. Hoffman-Censits, Amaro Weiner-Taylor, Hikmat Al-Ahmadie, Garam Han, R. Katherine Alpaugh, Elizabeth R. Plimack, Eliezer M. Van Allen, Min Yuen Teo, Kent W. Mouw, Jaegil Kim, Daniel Keliher, Stephanie A. Wankowicz, Levi A. Garraway, Essel Dulaimi, Catharine Kline Cipolla, Diana Miao, Gad Getz, David Y.T. Chen, David Liu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matched pre- and post-neoadjuvant cisplatin-bas
Autor:
Yukina Nishito, Takahiro Nagamura, Toshinari Takamura, Yuki Kuzuhara, Naoko Sakai, Miki Iwasaki, Yuya Yoshioka, Hirofumi Misu, Noriko Noguchi, Kanade Sotani, Shogo Inari, Yoshiro Saito, Kumi Inagaki, Kaho Nakayama, Yuichiro Mita, Masaya Ikegawa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we devel