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of 57
pro vyhledávání: ''
Autor:
Ze-Lin Li, Ji-Hong Liu, Xin-Hong Zhu, Qiang-Long You, Xiaochun Bai, Neng-Yuan Hu, Yan Wang, Jian-Ming Yang, Jiang-Ping Xu, Shu-Ji Li, Zeng-Lin Jin, Tian-Ming Gao, Yifan Dai, Qian Wang, Xiao-Wen Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on n
Autor:
Todd Hager, Jae Lee, Hongyan Li, David Lloyd, James R. Falsey, Elizabeth A. Killion, Bin Wu, Larissa Atangan, Yuan Cheng, Michelle Chen, Murielle M. Véniant, Joan Helmering, Glenn Sivits
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the g
Autor:
Charlotte Hansen, Marcus Altfeld, Claudia Marggraff, Jill Noll, Stefan Hoenow, Iris Bruchhaus, Nahla Galal Metwally, Marie Weskamm, Marie Groneberg, Christoph Dorn, Stephanie Stanelle-Bertram, Svenja Kuehl, Harald Ittrich, Thomas Jacobs, Sven Hendrik Hagen, Julie Sellau, Egbert Tannich, Julia Wernecke, Vincent Wolf, Helena Fehling, Thorsten Thye, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of
Autor:
Theodore P. Ciaraldi, Inês S. Lima, Yossi Dagon, Ji A Seo, Achana Vijyakumar, Jee In Heo, Vanita R. Aroda, Robert R. Henry, Hu Huang, Min-Cheol Kang, Won Mo Yang, Kyong Soo Park, Aykut Göktürk Üner, Soo Hong, Won Min Hwang, Sang Soo Kim, Leandro Pereira de Moura, Min Seon Kim, Thomas E. Willnow, Seung-Hwan Lee, Young-Bum Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (Apo
Autor:
Chung Owyang, Yuan Li, Martin G. Myers, Hong Shen, Haoran Su, Xiaoyin Wu, Min-Hyun Kim, Lin Jiang, Liangyou Rui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown
Autor:
Manish Kumar, Aralia Leon Coria, Steve Cornick, Björn Petri, Shyamchand Mayengbam, Humberto B. Jijon, France Moreau, Jane Shearer, Kris Chadee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Inflammatory bowel disease is associated with changes in the mucosal barrier, increased intestinal permeability, and increased risk of infections and sepsis, but the underlying mechanisms are incompletely understood. Here, we show how continuous tran
Autor:
Claudio Grassi, Cristian Ripoli, Marco Rinaudo, Salvatore Fusco, Sara Cocco, Alessia Mastrodonato, Matteo Spinelli, Francesca Natale, Giulia Livrizzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Metabolic diseases harm brain health and cognitive functions, but whether maternal metabolic unbalance may affect brain plasticity of next generations is still unclear. Here, we demonstrate that maternal high fat diet (HFD)-dependent insulin resistan
Autor:
Qing Gao, Luke Norton, Yuejuan Qin, Chris E. Shannon, Zi Ming Cheng, Muhammad A. Abdul-Ghani, Balakuntalam S. Kasinath, Anqi Luo, Nathan Harper, Xingyu Zhang, Marcel Fourcaudot, Patricia L. M. Dahia, Ricardo C.T. Aguiar, Subramanya Srikantan, Sifan Tao, Robert L. Reddick, Stephen Harrison, Sunil K. Ahuja, Zhi Li, Glaiza Mae Sande-Docor, Yilun Deng, Lily Q. Dong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Understanding the molecular components of insulin signaling is relevant to effectively manage insulin resistance. We investigated the phenotype of the TMEM127 tumor suppressor gene deficiency in vivo. Whole-body Tmem127 knockout mice have decreased a
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Autor:
Hiroaki Adachi, Naohide Kondo, Masahisa Katsuno, Madoka Iida, Shinobu Shimizu, Yohei Okada, Yutaka Tsutsumi, Gen Sobue, Hideaki Nakatsuji, Masahiro Nakatochi, Ayuka Murakami, Seiya Noda, Kentaro Sahashi, Yuka Tsukagoshi Okabe, Hideyuki Okano, Masaaki Mizuno, Kazunari Onodera, Genki Tohnai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor (AR) gene. Here, we perform a comprehensive analysis of signaling pathways in a mouse model of SBMA (AR-97Q mice) utilizing